Porous silicon microneedles and nanoneedles for biomedical applications

Chiappini, Ciro

doi:10.1016/b978-0-12-821677-4.00006-9

Cited by 1 publication

(1 citation statement)

References 54 publications

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“…[37][38][39][40] PSiO 2 acts not only as nanostructured scaffold but also as optical transducer thus demonstrating the advantage of the vaporphase approach enabling nanostructured MIP synthesis and integration with the transducer in a single step with no need of additional steps for scaffold removal and/or integration with the transducer, contrarily to what observed in other imprinting approaches for MIP nanostructuring. [22,41] Further, PSi has been increasingly exploited in optical (bio)sensing with organic bioreceptors, [42][43][44][45][46][47] thanks to the facile preparation of different optical structures (i.e., interferometers, [42,45,[48][49][50] resonant cavities, [51][52][53] and waveguides [54][55][56][57] ), high effective surface for the accommodation of receptors and target molecules (i.e., proteins, [44,45] DNA, [56,58,59] and drugs [60][61][62] ), intrinsic nanoscale filtering that enables operation of PSi sensors with complex biological fluids (i.e., saliva, [46,42] blood, [63,64] and interstitial fluid [65] ).…”

Section: Introductionmentioning

confidence: 99%

Vapor‐Phase Synthesis of Molecularly Imprinted Polymers on Nanostructured Materials at Room‐Temperature

Mazzotta

Giulio

Mariani

et al. 2023

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Molecularly imprinted polymers (MIPs) have recently emerged as robust and versatile artificial receptors. MIP synthesis is carried out in liquid phase and optimized on planar surfaces. Application of MIPs to nanostructured materials is challenging due to diffusion‐limited transport of monomers within the nanomaterial recesses, especially when the aspect ratio is >10. Here, the room temperature vapor‐phase synthesis of MIPs in nanostructured materials is reported. The vapor phase synthesis leverages a >1000‐fold increase in the diffusion coefficient of monomers in vapor phase, compared to liquid phase, to relax diffusion‐limited transport and enable the controlled synthesis of MIPs also in nanostructures with high aspect ratio. As proof‐of‐concept application, pyrrole is used as the functional monomer thanks to its large exploitation in MIP preparation; nanostructured porous silicon oxide (PSiO2) is chosen to assess the vapor‐phase deposition of PPy‐based MIP in nanostructures with aspect ratio >100; human hemoglobin (HHb) is selected as the target molecule for the preparation of a MIP‐based PSiO2 optical sensor. High sensitivity and selectivity, low detection limit, high stability and reusability are achieved in label‐free optical detection of HHb, also in human plasma and artificial serum. The proposed vapor‐phase synthesis of MIPs is immediately transferable to other nanomaterials, transducers, and proteins.

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