“…Recently, porous silicon has been applied in the biomedical research field, by generating porous silicon microparticles (pSiMPs) and nanoparticles (pSiNPs) [14,15,16,17,18,19,20,21,22,23]. The discovery of the quantum confinement effect and biodegradable property brings porous silicon into the spotlight [14,24,25,26,27]. In particular, pSiNPs display many advantages, including (i) high load efficiency toward substrates, such as drugs and peptides, (ii) superior controlled-release properties, (iii) no harmful byproduct generation after degradation, (iv) strong near-infrared (NIR) photoluminescence and two-photon (TP) absorbing ability for bio-imaging, (v) negligible cytotoxicity, and (vi) cell/organ/bacteria specific targeting abilities through fabrication of the surface.…”