Porous Starch: a Novel Carrier for Solubility Enhancement of Carbamazepine

Ali, Meer Tarique; Fule, Ritesh; Sav, Ajay Kumar; Amin, Purnima D.

doi:10.1208/s12249-013-9985-6

Cited by 40 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…solid SNEDDS achieved greater than 80% probucol dissolution within approximately 15 min irrespective of media type, whereas porous starchprobucol achieved less than 5% dissolution within 60 min (similar to pure drug). This result is contrary to various other studies that have demonstrated the ability of porous starch to directly enhance poorly water-soluble drug dissolution (65,66). However, the larger pore sizes of the porous starch used by Zhang et al (i.e.…”

Section: Porous Starchcontrasting

confidence: 73%

Novel Nanostructured Solid Materials for Modulating Oral Drug Delivery from Solid-State Lipid-Based Drug Delivery Systems

Dening

Rao

Thomas

et al. 2015

AAPS J

View full text Add to dashboard Cite

Lipid-based drug delivery systems (LBDDS) have gained significant attention in recent times, owing to their ability to overcome the challenges limiting the oral delivery of poorly water-soluble drugs. Despite the successful commercialization of several LBDDS products over the years, a large discrepancy exists between the number of poorly water-soluble drugs displaying suboptimal in vivo performances and the application of LBDDS to mitigate their various delivery challenges. Conventional LBDDS, including lipid solutions and suspensions, emulsions, and self-emulsifying formulations, suffer from various drawbacks limiting their widespread use and commercialization. Accordingly, solid-state LBDDS, fabricated by adsorbing LBDDS onto a chemically inert solid carrier material, have attracted substantial interest as a viable means of stabilizing LBDDS whilst eliminating some of the various limitations. This review describes the impact of solid carrier choice on LBDDS performance and highlights the importance of appropriate solid carrier material selection when designing hybrid solid-state LBDDS. Specifically, emphasis is placed on discussing the ability of the specific solid carrier to modulate drug release, control lipase action and lipid digestion, and enhance biopharmaceutical performance above the original liquid-state LBDDS. To encourage the interested reader to consider their solid carrier choice on a higher level, various novel materials with the potential for future use as solid carriers for LBDDS are described. This review is highly significant in guiding future research directions in the solid-state LBDDS field and fostering the translation of these delivery systems to the pharmaceutical marketplace.

show abstract

Section: Porous Starchcontrasting

confidence: 73%

Novel Nanostructured Solid Materials for Modulating Oral Drug Delivery from Solid-State Lipid-Based Drug Delivery Systems

Dening

Rao

Thomas

et al. 2015

AAPS J

View full text Add to dashboard Cite

show abstract

“…The specific surface area (SSA), total pore volume (TPV) and micropore volume (MV) of PS are at around 3 m 2 /g, 11 Â 10 À3 cm 3 /g and 3 Â 10 À3 cm 3 /g, respectively [3]. Interestingly, Brunauer-Emmett-Teller (BET) estimation yields higher values as 109.73 m 2 /g for SSA with pore sizes at around 200 nm and TPV of 32 Â 10 À3 cm 3 /g [4]. These are much smaller compared to the inorganic adsorbents.…”

Section: Introductionmentioning

confidence: 99%

The physical and adsorption properties of different modified corn starches

Sun

et al. 2015

Starch Stärke

View full text Add to dashboard Cite

In order to improve the physical and adsorption properties of native corn starch, porous starch was prepared. Furthermore, dual‐modification of starches – enzyme hydrolyzed starch followed by cross‐linking as well as enzyme hydrolysis upon cross‐linking was explored. The results suggested that enzyme hydrolyzed starch followed by cross‐linking was significantly different from enzyme hydrolysis upon cross‐linking. The granular specific surface area of the dual‐modified starches was more than thousand orders of native corn starch. Crosslinked starch phosphates and enzyme hydrolyzed starch followed by cross‐linking had higher gelatinization temperature than porous starch and cross‐linked starch followed by enzyme hydrolysis. The ΔH of crosslinked starch phosphates and dual‐modification of starches were larger than that of native corn starch and porous starch, which indicates that the cross‐linking strengthens the starch granules and hence more energy is required for disruption. The absorption capacities of enzyme hydrolyzed starch followed by cross‐linking and enzyme hydrolysis upon cross‐linking were 5 times more than that of native corn starch, crosslinked starch phosphates and porous starch. Overall, it is concluded that the combination of cross‐linking and enzyme hydrolysis is a favorable approach to increase the mechanical strength and adsorptive capacity of porous starches.

show abstract

“…Carbamazepine (CBZ), which is practically insoluble in water, was loaded into PS. 90 The drug release from CBZ-loaded PS showed to be complete within only 20 min. The signicantly improved dissolution is believed to be due to (a) high surface area of drug; (b) geometric connement of CBZ within the pores of PS and, thus, the reduction of the CBZ particle size; and (c) improved wettability and decreased crystallinity of drug, both of which originally make CBZ insoluble.…”

Section: Porous Starch (Ps)mentioning

confidence: 95%