Porous tantalum oxide with osteoconductive elements and antibacterial core-shell nanoparticles: A new generation of materials for dental implants

Fialho, Luísa; Grenho, Liliana; Fernandes, Maria Helena; Carvalho, S.

doi:10.1016/j.msec.2020.111761

Cited by 36 publications

(38 citation statements)

References 62 publications

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“…We have recently reported the Ta surface treatment by MAO at 200 V, and that using an identical electrolyte composition but with a higher concentration develops an oxide layer with a porous morphology similar to the morphology obtained by Wang et al [ 65 , 69 ], without dendritic structures [ 73 , 74 ]. Moreover, the influence of the electrolyte composition (CaA, CaA + β-GP, CaA + β-GP + MgA) and concentration on the morphology was also studied.…”

Section: Ta 2 O 5 Surfaces For ...supporting

confidence: 62%

“…For certain applications, it is desired to dope the anodic coating with specific elements to tailor specific properties. In this regard, the incorporation of Ca and P elements onto the oxide coating has been demonstrated, which increases with the increase in the MAO time and the applied potential ( Figure 10 A in insets) [ 55 , 65 , 69 , 71 , 72 , 73 ], as well as when increasing the electrolyte concentration [ 73 , 74 ]. Interestingly, when increasing the β-GP concentration in the electrolyte, a boost in Ca incorporation is also noted, besides the P incorporation increase.…”

Section: Ta 2 O 5 Surfaces For ...mentioning

confidence: 99%

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A Decade of Progress on MAO-Treated Tantalum Surfaces: Advances and Contributions for Biomedical Applications

2022

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Micro-structured coatings with functional properties have been investigated due to a wide range of applications. It is known that micro-structures can play an important role in surface interactions determining the materials’ performance. Amongst the other materials, there has been an increasing interest in tantalum oxide (Ta2O5). This attention is mainly due to its variety of properties: biocompatibility and bioactivity; high dielectric constant; good thermal and chemical stability; excellent corrosion and mechanical resistance. Moreover, there is a wide range of applications in which the properties can be fitted. Furthermore, according to the final application, these properties can be enhanced or tailored through surface micro-structures manipulation. Due to this purpose, over the past decade, Ta surface modification by micro-arc oxidation (MAO) has been investigated mostly for biomedical applications. Therefore, this review focuses on Ta surface functionalization using the MAO technique. A clear understanding of the micro-discharge phenomena and the formation mechanism of a Ta2O5 anodic coating by MAO is supplied. The Ta2O5 coating morphology, topography, chemistry, and structure are explored, establishing their correlation with the MAO parameters. Additionally, an understanding of Ta2O5’s biological, mechanical, and electrochemical properties is provided and reviewed.

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Section: Ta 2 O 5 Surfaces For ...supporting

confidence: 62%

Section: Ta 2 O 5 Surfaces For ...mentioning

confidence: 99%

A Decade of Progress on MAO-Treated Tantalum Surfaces: Advances and Contributions for Biomedical Applications

2022

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“…The coating was biologically active because of its Ca/P-rich content. It has been confirmed that the coating on titanium alloy surface constructed by MAO can effectively reduce the release of cytotoxic Al and V elements, and the Ca/P in the coating can be dissolved in a small amount in a calcium-deficient environment which can promote the deposition of hydroxyapatite (29)(30)(31). The micro-nano porous structure and chemical composition of the coating enabled better biocompatibility and osteogenic induction of the porous titanium scaffold.…”

Section: Discussionmentioning

confidence: 89%

Effect of micro-arc oxidation surface modification of 3D-printed porous titanium alloys on biological properties

Ni¹,

Jing²,

Xiong³

et al. 2022

Ann Transl Med

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Background: Three-dimensional (3D) printing technology has been widely used in orthopedics; however, it is still limited to the change of macroscopic structures. In order to further improve the biological properties of 3D-printed porous titanium scaffolds, this study introduced micro-arc oxidation (MAO) technology to modify the surface of porous titanium scaffolds and construct bioactive coatings on the surface of porous titanium scaffolds to improve the biocompatibility and osseointegration ability of the material.Methods: For in vitro experiments, human bone marrow stem cells (hBMSCs) were seeded onto untreated scaffolds (control group) and MAO-treated scaffolds (experimental group). After 24 h of co-culture, cytotoxicity was observed using live/dead staining, and cell/scaffold constructs were retrieved and processed for the assessment of cell morphology by using scanning electron microscopy (SEM). Cell proliferation was detected using the Cell Counting Kit-8 (CCK-8) assay after 3, 7, and 14 days of co-culture. The levels of alkaline phosphatase (ALP) in the cell supernatant were detected after 7 and 14 days of co-culture. For in vivo experiments, micro-computed tomography (micro-CT) and Masson Goldner's staining were used to evaluate bone ingrowth and osseointegration at 4 and 8 weeks postoperatively.Results: In vitro experiment results confirmed that the two groups of scaffolds were non-cytotoxic and the cell adhesion status on the MAO-treated scaffolds was better. Over time, cell proliferation and ALP levels were higher in the MAO-treated group than in the untreated scaffolds. In the in vivo experiments, the MAOtreated scaffolds showed better bone ingrowth and osseointegration than the untreated group at different time points. Conclusions:The MAO-treated porous titanium scaffold formed a uniform and dense bioactive coating on the surface, which was more conducive to cell adhesion, proliferation, and differentiation and showed better osseointegration and bone ingrowth in vivo.

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“…Katouno et al [144] observed a higher calcification of osteoblast cultures using Zn-DLC when compared to a bare DLC coating. On the other hand, Fialho et al [145] showed a more controlled release of Zn ions when a tantalum oxide-zinc nanoparticle surface was covered by a carbon thin layer. For the deposition of the DLC layer, they used magnetron sputtering and acetylene (C 2 H 2 ) as the carbon precursor.…”

Section: Preparation Method: Physical Vapor Depositionmentioning

confidence: 99%

Overview on the Antimicrobial Activity and Biocompatibility of Sputtered Carbon-Based Coatings

et al. 2021

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Due to their outstanding properties, carbon-based structures have received much attention from the scientific community. Their applications are diverse and include use in coatings on self-lubricating systems for anti-wear situations, thin films deposited on prosthetic elements, catalysis structures, or water remediation devices. From these applications, the ones that require the most careful testing and improvement are biomedical applications. The biocompatibility and antibacterial issues of medical devices remain a concern, as several prostheses still fail after several years of implantation and biofilm formation remains a real risk to the success of a device. Sputtered deposition prevents the introduction of hazardous chemical elements during the preparation of coatings, and this technique is environmentally friendly. In addition, the mechanical properties of C-based coatings are remarkable. In this paper, the latest advances in sputtering methods and biocompatibility and antibacterial action for diamond-based carbon (DLC)-based coatings are reviewed and the greater outlook is then discussed.

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Porous tantalum oxide with osteoconductive elements and antibacterial core-shell nanoparticles: A new generation of materials for dental implants

Cited by 36 publications

References 62 publications

A Decade of Progress on MAO-Treated Tantalum Surfaces: Advances and Contributions for Biomedical Applications

A Decade of Progress on MAO-Treated Tantalum Surfaces: Advances and Contributions for Biomedical Applications

Effect of micro-arc oxidation surface modification of 3D-printed porous titanium alloys on biological properties

Overview on the Antimicrobial Activity and Biocompatibility of Sputtered Carbon-Based Coatings

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