Porous ultrathin-shell microcapsules designed by microfluidics for selective permeation and stimuli-triggered release

Microfluidic Fabrication of Calcium Alginate/Chitosan Composite Microcapsules with Ultrathin Shells for Peroxidase Immobilization

“…As shown in Figure a, a two-stage capillary microfluidic device was assembled to prepare monodisperse W/O/W emulsion templates . All cylindrical capillary tubes of the two-stage microfluidic device had an outer diameter of 960 μm.…”

“…As shown in Figure 1a, a two-stage capillary microfluidic device was assembled to prepare monodisperse W/O/W emulsion templates. 32 All cylindrical capillary tubes of the two-stage microfluidic device had an outer diameter of 960 μm. The inner diameter of the injection tube was 550 μm, and the inner diameter of its tapered mouth was 40 μm.…”

Revolutionizing targeting precision: microfluidics-enabled smart microcapsules for tailored delivery and controlled release

“…For instance, a porous shell made of 20 nm shellac nanoparticles crosslinked by telechelic polymers can allow for the transport of 1 nm rhodamine B while encapsulating 60 nm particles in the cores. 152 In particular, when the molecular size is significantly smaller than the pore size, the transport rate of the encapsulants is not affected by the size of the particles that form the shell. 153 To enhance the mechanical property of the colloidal shell, low diluent concentrations and densely interconnected particle networks were designed and exhibited a force at a break up to 200 mN.…”

Microencapsulation of alcohol solvents and high-content actives for efficient transdermal delivery

“…7 Alternatively, emulsion-templated microcapsules and vesicles, which can effectively enclose the inner solvent phase containing the desired actives within a shell material have been proposed. 8,9,30–32 While photopolymerizable perfluoropolyethers (PFPEs) and low molecular weight poly(ethylene glycol diacrylate) (PEGDA) have been exploited as the shell material for the microencapsulation of a broad range of solvents, they are either not biocompatible, only offer a limited selection of compatible solvents, or leave shell debris after rupture. 10,11…”

“…7 Alternatively, emulsiontemplated microcapsules and vesicles, which can effectively enclose the inner solvent phase containing the desired actives within a shell material have been proposed. 8,9,[30][31][32] While photopolymerizable perfluoropolyethers (PFPEs) and low molecular weight poly(ethylene glycol diacrylate) (PEGDA) have been exploited as the shell material for the microencapsulation of a broad range of solvents, they are either not biocompatible, only offer a limited selection of compatible solvents, or leave shell debris after rupture. 10,11 On the other hand, to overcome the skin barrier layer and facilitate the permeation of cosmetic actives, skin penetration enhancers (SPEs), such as ceramide and fatty acids found in skin, have been incorporated in lipid-based formulations for the effective transdermal delivery of hydrophilic actives.…”