Porphyrin Trio−Pendant fullerene guest as an In situ universal probe of high ECL efficiency for sensitive miRNA detection

Liu, Guang; Hong, Jiajin; Ma, Kefeng; Wan, Ying; Zhang, Xutong; Huang, Yaqi; Kang, Kai; Yang, Meng; Chen, Jialiang; Deng, Shengyuan

doi:10.1016/j.bios.2019.111963

Cited by 18 publications

(17 citation statements)

References 51 publications

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“…β-Cyclodextrin (β-CD), a macrocycle consists of seven glucose units, is extracted from corn starch and therefore does not have toxicity. β-CD has a hollow cone structure with a lipophilic cavity and a hydrophilic outer surface, which has served as a versatile host competent in formation of inclusion complexes with thousands of lipophilic guest molecules. , For example, by using two cyclodextrin hosts (pyridyl-bridged β-cyclodextrin dimer and gamma-cyclodextrin), Deng et al judiciously pinched zinc porphyrin guest into them through host–guest interaction, and the obtained inclusions were found to exhibit dramatically boosted ECL activity when relative to zinc porphyrin itself. Additionally, the secondary hydroxyl groups on the larger open end and the primary hydroxyl groups on the smaller open end of cone structure of β-CD are able to form self-assemblies with organic molecules via hydrogen bonding interaction, hydrophobic interaction, and host–guest matching effect.…”

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confidence: 99%

Depolymerization-Induced Electrochemiluminescence of Insoluble Porphyrin in Aqueous Phase

Han

Wei

et al. 2020

Anal. Chem.

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Exploring efficient and robust electrochemiluminescence (ECL) performance of liposoluble porphyrins in aqueous phase for analytical purposes especially for important biological targets is still very challenging. In this work, a novel depolymerization-induced electrochemiluminescence (DIECL) of porphyrin and β-cyclodextrin (β-CD) self-assembly through a coreactant route was discovered. Among the studied meso-tetrasubstituted porphyrins, self-assembly of 5,10,15,20-tetrakis(4-hydroxyphenyl) porphyrin (THPP) and β-CD (THPP@β-CD) exhibits the best DIECL behavior with high efficiency (21.8%) as well as good reproducibility and stability. A mechanistic study suggests that the facile complexation of porphyrins with amphiphilic β-CD via hydrogen bonding interaction greatly improves the water insolubility and the aggregation-caused deficient ECL of liposoluble porphyrins in aqueous solution. Furthermore, because of the strong hydrogen bonding between the hydroxyl groups on THPP@β-CD and a highly electronegative substrate, such THPP@β-CD is found to serve as an efficient luminophore for recognition of most electronegative fluoride (F–) in the aqueous phase with high sensitivity and selectivity, together with a low limit of detection (0.74 μΜ). The simplicity of this THPP@β-CD and its unique DIECL property in current work provides a new guide for the ECL applications of liposoluble porphyrins in aqueous phase.

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confidence: 99%

Depolymerization-Induced Electrochemiluminescence of Insoluble Porphyrin in Aqueous Phase

Han

Wei

et al. 2020

Anal. Chem.

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“…A luminophore can induce a dual-band ECL emission at two wavelengths under chemical reactions employing different co-reactants and co-reaction accelerators. Bipolar ECL emitters were used as luminophores in order to detect multiple biomarkers [ 32 , 37 , 54 , 74 ]. For example, Au 25 nanoclusters (NCs) exhibit cathodic and anodic ECL emissions using different co-reactants and co-reaction accelerators [ 75 ].…”

Section: Current Strategies and Technologies Of The Ecl Systems In Th...mentioning

confidence: 99%

Electrochemiluminescence Systems for the Detection of Biomarkers: Strategical and Technological Advances

2022

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Electrochemiluminescence (ECL)-based sensing systems rely on light emissions from luminophores, which are generated by high-energy electron transfer reactions between electrogenerated species on an electrode. ECL systems have been widely used in the detection and monitoring of diverse, disease-related biomarkers due to their high selectivity and fast response times, as well as their spatial and temporal control of luminance, high controllability, and a wide detection range. This review focuses on the recent strategic and technological advances in ECL-based biomarker detection systems. We introduce several sensing systems for medical applications that are classified according to the reactions that drive ECL signal emissions. We also provide recent examples of sensing strategies and technologies based on factors that enhance sensitivity and multiplexing abilities as well as simplify sensing procedures. This review also discusses the potential strategies and technologies for the development of ECL systems with an enhanced detection ability.

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“…Deng and coworkers developed an elegant multicomponent system basing on host-guest chemistry of γ-CD, including fullerene and Zn porphyrins for the sub-picomolar detection of a model miRNA. Fabrication route and working mechanism are depicted in Figure 12 [59]. In this system, the hybrid C 60 (ZnTPP) 3 , was noncovalently but firmly embedded in the hollow of γCDs and anchored on AuNPs, functionalized with tiolated-γCDs that acted as hosting receptors for guest inclusion.…”

Section: Miscellaneousmentioning

confidence: 99%

Recent Advances in Chemical Sensors Using Porphyrin-Carbon Nanostructure Hybrid Materials

et al. 2021

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Porphyrins and carbon nanomaterials are among the most widely investigated and applied compounds, both offering multiple options to modulate their optical, electronic and magnetic properties by easy and well-established synthetic manipulations. Individually, they play a leading role in the development of efficient and robust chemical sensors, where they detect a plethora of analytes of practical relevance. But even more interesting, the merging of the peculiar features of these single components into hybrid nanostructures results in novel materials with amplified sensing properties exploitable in different application fields, covering the areas of health, food, environment and so on. In this contribution, we focused on recent examples reported in literature illustrating the integration of different carbon materials (i.e., graphene, nanotubes and carbon dots) and (metallo)porphyrins in heterostructures exploited in chemical sensors operating in liquid as well as gaseous phase, with particular focus on research performed in the last four years.

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Porphyrin Trio−Pendant fullerene guest as an In situ universal probe of high ECL efficiency for sensitive miRNA detection

Cited by 18 publications

References 51 publications

Depolymerization-Induced Electrochemiluminescence of Insoluble Porphyrin in Aqueous Phase

Depolymerization-Induced Electrochemiluminescence of Insoluble Porphyrin in Aqueous Phase

Electrochemiluminescence Systems for the Detection of Biomarkers: Strategical and Technological Advances

Recent Advances in Chemical Sensors Using Porphyrin-Carbon Nanostructure Hybrid Materials

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