Porphyrinic Metal–Organic Frameworks Coated Gold Nanorods as a Versatile Nanoplatform for Combined Photodynamic/Photothermal/Chemotherapy of Tumor

Zeng, Jingjing; Zhang, Ming-Kang; Peng, Mengyun; Gong, De; Zhang, Xian‐Zheng

doi:10.1002/adfm.201705451

Cited by 251 publications

(146 citation statements)

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“…One approach is embedding innumerable AuNPs into the channel of MOF to form honeycomb structure by in situ growth of impregnating gold precursors . The other is encapsulating a single AuNP into the center of MOF to form core–shell structure by addition of suitable chemicals . Due to the limitation of pore size, anisotropic gold nanoparticles (such as gold nanorods, nanostars, and nanobipyramids) can only be used as core to construct MOF‐based core–shell nanocomposites.…”

Section: Methodsmentioning

confidence: 99%

ZD2‐Engineered Gold Nanostar@Metal‐Organic Framework Nanoprobes for T₁‐Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically Toward Triple‐Negative Breast Cancer

Zhang

LIU

Gao

et al. 2018

Adv Healthcare Materials

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Section: Methodsmentioning

confidence: 99%

ZD2‐Engineered Gold Nanostar@Metal‐Organic Framework Nanoprobes for T₁‐Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically Toward Triple‐Negative Breast Cancer

Zhang

LIU

Gao

et al. 2018

Adv Healthcare Materials

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“…Here,wealso used aMOF with high ROSactivity,PCN-224, for comparison. [11] This MOF was composed of TCPP,w hich was capable to generate ROS on its own ( Figure 2H). ROS generation rate of COF-909 even exceled that of PCN-224, while the molecular building block of COF-909 was inactive.…”

mentioning

confidence: 99%

Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy

et al. 2019

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Covalent organic frameworks (COFs) with 2D π‐conjugation were designed and synthesized as molecular photosensitizers for efficient photodynamic therapy. Two molecules, 5′,5′′′′‐(1,4‐phenylene)bis(([1,1′:3′,1′′‐terphenyl]‐4,4′′‐dicarbaldehyde)) (L‐3C) and 4,4′,4′′‐(1,4‐phenylene)bis(([2,2′:6′,2′′‐terpyridine]‐5,5′′‐dicarbaldehyde)) (L‐3N), inactive to generating reactive oxygen species (ROS), were linked to form two COFs, COF‐808 and COF‐909, respectively, exhibiting excellent ROS production efficiency. The high permanent porosity of these COFs (surface areas 2270 and 2610 m2 g−1) promoted diffusion of both oxygen and release of ROS in cells. This, combined with the excellent photostability and biocompatibility, led to excellent PDT performance. In vitro, over 80 % of tumor cells were killed after PDT treatment using COF‐909 at the concentration of 50 μg mL−1 for 150 s. In vivo, drastic reduction of tumor size was observed (from 9 mm to less than 1 mm) after 10 day treatment.

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“…To further confirm the photo‐cytotoxicity of T820/Ce6 micelles and clarify the mechanism of cell death induced by the micelles, cell apoptosis and necrosis were evaluated by apoptosis assay using Annexin‐V‐FITC (fluorescein isothiocyanate)/PI (propidium iodide) double staining . As illustrated in Figure , cell growth was not affected by laser irradiation, and treatment of free Ce6, T820 micelles, or T820/Ce6 micelles in darkness brought death to a small portion of the cells.…”

Section: Resultsmentioning

confidence: 99%

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

Tian

Jiang

et al. 2018

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triggered by near-infrared (NIR) lightexcited photothermal agents [10] while PDT causes the cell death by photosensitizers generating highly cytotoxic reactive oxygen species (ROS) upon light excitation. [11][12][13] With distinct mechanisms of action, the integration of PTT and PDT into one nanoplatform holds great potential to achieve highly efficient cancer therapy. [14][15][16] However, in such combined therapy, two different excitation wavelengths are usually required for the activation of PTT and PDT, [17][18][19] leading to complicated treatment process and prolonged therapeutic time. Thus, it is highly desirable to design a nanoplatform with single NIR light-induced phototherapy.Although strategies of single-wavelength NIR light-mediated PTT/PDT combination therapy have been reported, photothermal agents commonly used in combined systems are inorganic nanomaterials, like gold nanostructures, [20][21][22] MoS 2 nanosheets, [23] black phosphorus nanosheets, [24] and black titania, [25] which show tedious preparation process, poor degradation, difficult excretion, and potential long-term toxicity. NIR organic dyes, which possess unique advantages of outstanding biodegradability and biocompatibility in contrast with inorganic photothermal agents, will be ideal alternatives. Especially, for new indocyanine green (IR820), a structural analog of indocyanine green (ICG), which has been approved by the Food and Drug Administration (FDA) in clinical use, [26][27][28] holds the suitable fluorescence, strong absorption in NIR region, and efficient light-thermal conversion. [29,30] Additionally, it is more stable and easily modified due to the meso-halogen in its chemical structure. Unfortunately, it differs from organic photodynamic agents in intrinsic excitation wavelength, bringing a great challenge to achieve single NIR laser-induced combinational phototherapy. Moreover, it suffers from short half-life in blood, rapid clearance from the body, and lack of specificity to target tumor area. [31,32] Chlorin e6 (Ce6), an FDA-approved second-generation photosensitizer, [33] is extensively used in PDT on account of its high singlet oxygen generation efficiency, [34] near-infrared light excitation allowing deep tissue penetration, and fluorescence imaging capability. [35,36] Despite these upsides, Ce6 has shortcomings including poor water solubility and nonspecific accumulation in tumor sites, [37] which largely compromise Phototherapy as a promising cancer diagnostic and therapeutic strategy has aroused extensive attention. However, single-wavelength near-infrared (NIR) light-triggered combinational treatment of photothermal therapy (PTT) and photodynamic therapy (PDT) is still a great challenge. Herein, a multifunctional micelle activated by a single-wavelength laser for simultaneous PTT and PDT as well as fluorescence imaging is developed. Briefly, new indocyanine green (IR820) is conjugated to d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) via the linker 6-aminocaproic acid, and then, chlorin e6 (Ce6) is enc...

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Porphyrinic Metal–Organic Frameworks Coated Gold Nanorods as a Versatile Nanoplatform for Combined Photodynamic/Photothermal/Chemotherapy of Tumor

Cited by 251 publications

References 55 publications

ZD2‐Engineered Gold Nanostar@Metal‐Organic Framework Nanoprobes for T₁‐Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically Toward Triple‐Negative Breast Cancer

ZD2‐Engineered Gold Nanostar@Metal‐Organic Framework Nanoprobes for T₁‐Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically Toward Triple‐Negative Breast Cancer

Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

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Porphyrinic Metal–Organic Frameworks Coated Gold Nanorods as a Versatile Nanoplatform for Combined Photodynamic/Photothermal/Chemotherapy of Tumor

Cited by 251 publications

References 55 publications

ZD2‐Engineered Gold Nanostar@Metal‐Organic Framework Nanoprobes for T1‐Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically Toward Triple‐Negative Breast Cancer

ZD2‐Engineered Gold Nanostar@Metal‐Organic Framework Nanoprobes for T1‐Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically Toward Triple‐Negative Breast Cancer

Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

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Product

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ZD2‐Engineered Gold Nanostar@Metal‐Organic Framework Nanoprobes for T₁‐Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically Toward Triple‐Negative Breast Cancer

ZD2‐Engineered Gold Nanostar@Metal‐Organic Framework Nanoprobes for T₁‐Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically Toward Triple‐Negative Breast Cancer