Porphyromonas gingivalis as a Possible Risk Factor in the Development/Severity of Acute Alcoholic Hepatitis

Zhou, Yun; Vatsalya, Vatsalya; Gobejishvili, Leila; Lamont, Richard J.; McClain, Craig J.; Feng, Wenke

doi:10.1002/hep4.1296

Cited by 19 publications

(17 citation statements)

References 46 publications

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“…These results were in agreement with the study conducted in Jordan 39 . Porphyromonas gingivalis is a risk factor for alcohol‐related hepatitis, 40 indicating that Porphyromonas genus is associated with alcohol drinking. Since oral hygiene habits are mainly related to age, 41 the association network between age and salivary microbial taxa was also found to be similar to that of OHI.…”

Section: Discussionmentioning

confidence: 99%

Alterations in the oral and gut microbiome of colorectal cancer patients and association with host clinical factors

Wang

Zhang

Qian

et al. 2021

Intl Journal of Cancer

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Previous studies have suggested that gut microbiota plays a critical role in colorectal cancer (CRC). Although preliminary comparisons of the oral and gut microbiota between CRC and healthy control (HC) patients have been made, the association between microbiome abundance and host clinical factors has not been fully illustrated, especially oral health conditions. Matching samples of unstimulated saliva, cancer tissues or biopsies and stools were collected from 30 CRC and 30 HC patients from Shanghai Jiao Tong University affiliated Renji Hospital for 16S rRNA sequencing analysis. The diversity in salivary and mucosal microbiome, but not stool microbiome of CRC group, was significantly different from that of HC, as demonstrated by the Principal Component Analysis. Logistic regression analysis revealed that older age and higher oral hygiene index (OHI) were independent risk factors for CRC, with odds ratios and 95% confidence intervals of 1.159 (1.045‐1.284) and 4.398 (1.328‐14.567), respectively. Salivary Firmicutes to Bacteroides ratio in CRC was significantly higher than that in the HC group (P < .001), while the mucosal ratio was slightly decreased in CRC (P < .05). Salivary Rothia and Streptococcus levels were positively correlated with OHI, while Alloprevotella, Fusobacterium, Peptostreptoccus and Prevotella genera levels were negatively associated with OHI. NetShift analysis revealed that salivary Peptococcus, Centipeda and mucosal Subdoligranulum genus might act as key drivers during the process of carcinogenesis. In conclusion, the current study provides insights into the potential influence of host clinical factors on oral and gut microbiome composition and can be a guide for future studies.

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Section: Discussionmentioning

confidence: 99%

Alterations in the oral and gut microbiome of colorectal cancer patients and association with host clinical factors

Wang

Zhang

Qian

et al. 2021

Intl Journal of Cancer

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“… 91 More recently, a study showed an association of P. gingivalis with acute alcoholic hepatitis (AAH) development/progression. 88 Patients with severe AAH showed significantly higher plasma levels of IgG, IgA, and IgM against two P. gingivalis strains (W83 and 33277) compared to healthy controls. Patients with moderate AAH also had significantly elevated anti- P. gingivalis IgA concentrations of both strains compared to healthy controls.…”

Section: Oral Microbiota Dysbiosis and Aldmentioning

confidence: 91%

“… 84 , 85 P. gingivalis can also be swallowed with saliva and enter the intestine, 86 , 87 causing liver disease via the gut-liver axis. 88 Periodontitis is associated with increased hepatic fibrosis in human subjects with NAFLD and P. gingivalis worsens steatohepatitis in mice fed a high-fat diet. Interestingly, a program of dental hygiene therapy improved NAFLD in humans.…”

Section: Oral Microbiota Dysbiosis and Aldmentioning

confidence: 99%

Microbiome dysbiosis and alcoholic liver disease

McClain

Feng

2019

Liver Research

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Microbiome dysbiosis is strongly associated with alcoholic liver disease (ALD). Recent studies on comprehensive analyses of microbiome compositional and functional changes have begun to uncover the mechanistic relation between microbiome and the pathogenesis of ALD. Importantly, targeting the microbiome has become a potential strategy for the prevention and treatment of ALD. In this review, we summarize the clinical evidence of microbiome dysbiosis in ALD patients, and experimental advances in microbiome and metabolomic functional changes in animals with different species and genetic backgrounds in ALD. We also summarize the studies in humanized intestinal microbiome and fecal microbiota transplantation in mice. We introduce new developments in the studies on the role of the circulating bacterial microbiome, oral bacterial microbiome and fungal microbiome in the development of ALD. We highlight the potential mechanisms by which microbiome dysbiosis contributes to ALD, including short chain fatty acid changes, bile acid metabolism, intestinal barrier function, release of bacterial and fungal products, and inflammation. In addition, we summarize the recent developments targeting the microbiome in prevention and treatment of ALD, including dietary nutrient interference, herbal medicine, antibiotics, anti-fungal agents, probiotics, engineered bacterial therapy, fecal transplantation and oral hygiene. Although recent preclinical studies have advanced our understanding of the microbiome and ALD, clinical studies, especially prospective studies with large samples, are needed to better understand the cause-effect of microbiome dysbiosis in ALD. Identifying new precision-based strategies targeting the microbiome are expected to be developed as more effective therapies in ALD.

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“…Hepatic tissues from patients with severe alcoholic hepatitis were obtained from the Resources Center of Johns Hopkins University. Details of characterizations and eligibility of human subjects have been described previously [25–27] and also in Supplementary materials and methods.…”

Section: Methodsmentioning

confidence: 99%

Cathelicidin‐related antimicrobial peptide alleviates alcoholic liver disease through inhibiting inflammasome activation

Zhao

Shao

et al. 2020

The Journal of Pathology

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Alcoholic liver disease (ALD) is associated with gut dysbiosis and hepatic inflammasome activation. While it is known that antimicrobial peptides (AMPs) play a critical role in the regulation of bacterial homeostasis in ALD, the functional role of AMPs in the alcohol-induced inflammasome activation is unclear. The aim of this study was to determine the effects of cathelicidin-related antimicrobial peptide (CRAMP) on inflammasome activation in ALD. CRAMP knockout (Camp −/−) and wild-type (WT) mice were subjected to binge-on-chronic alcohol feeding and synthetic CRAMP peptide was administered. Serum/plasma and hepatic tissue samples from human subjects with alcohol use disorder and/or alcoholic hepatitis were analyzed. CRAMP deficiency exacerbated ALD with enhanced inflammasome activation as shown by elevated serum interleukin (IL)-1β levels. Although Camp −/− mice had comparable serum endotoxin levels compared to WT mice after alcohol feeding, hepatic lipopolysaccharide (LPS) binding protein (LBP) and cluster of differentiation (CD) 14 were increased. Serum levels of uric acid (UA), a Signal 2 molecule in inflammasome activation, were positively correlated with serum levels of IL-1β in alcohol use disorder patients with ALD and were increased in Camp −/− mice fed alcohol. In vitro studies showed that CRAMP peptide inhibited LPS binding to macrophages and inflammasome activation stimulated by a combination of LPS and UA. Synthetic CRAMP peptide administration decreased serum UA and IL-1β concentrations and rescued the liver from alcohol-induced damage in both WT and Camp −/− mice. In summary, CRAMP exhibited a protective role against binge-on-chronic alcohol-induced liver damage via regulation of inflammasome activation by decreasing LPS binding and UA production. CRAMP administration may represent a novel strategy for treating ALD.

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Porphyromonas gingivalis as a Possible Risk Factor in the Development/Severity of Acute Alcoholic Hepatitis

Cited by 19 publications

References 46 publications

Alterations in the oral and gut microbiome of colorectal cancer patients and association with host clinical factors

Alterations in the oral and gut microbiome of colorectal cancer patients and association with host clinical factors

Microbiome dysbiosis and alcoholic liver disease

Cathelicidin‐related antimicrobial peptide alleviates alcoholic liver disease through inhibiting inflammasome activation

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