Porric acid D from marine-derived fungus Alternaria sp. isolated from Bohai Sea

Xu, Xiuli; Zhao, Shujiang; Jun-li, Wei; Fang, Nianqiao; Yin, Liyuan; Sun, Jiufeng

doi:10.1007/s10600-012-0097-4

Cited by 17 publications

(11 citation statements)

References 7 publications

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“…(Bohai Sea, Tianjin, China), was weakly inhibitory to S. aureus. 150 The hydroanthraquinone-derived tetrahydroaltersolanols C-F 126-129 and dihydroaltersolanol A 130, in addition to the alterporriol-type anthranoid dimers alterporriols N-R 131-135, were obtained from Alternaria sp. (so coral Sarcophyton sp., Weizhou coral reef, South China Sea).…”

Section: Marine-sourced Fungi (Excluding From Mangroves)mentioning

confidence: 99%

Marine natural products

et al. 2014

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This review covers the literature published in 2012 for marine natural products, with 1035 citations (673 for the period January to December 2012) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1241 for 2012), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Marine-sourced Fungi (Excluding From Mangroves)mentioning

confidence: 99%

Marine natural products

et al. 2014

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“…Altenusin ( 241 ) and porric acid D ( 243 ) from Alternaria sp. showed inhibitory activity against Staphyloccus aureus with MICs of 100 μg/mL and 25 μg/mL, respectively [ 123 ]. (4S)-α,β-Dehydrocurvularin ( 250 ) from Alternaria sp.…”

Section: Biological Activities and Functionsmentioning

confidence: 99%

Metabolites from Alternaria Fungi and Their Bioactivities

et al. 2013

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Alternaria is a cosmopolitan fungal genus widely distributing in soil and organic matter. It includes saprophytic, endophytic and pathogenic species. At least 268 metabolites from Alternaria fungi have been reported in the past few decades. They mainly include nitrogen-containing metabolites, steroids, terpenoids, pyranones, quinones, and phenolics. This review aims to briefly summarize the structurally different metabolites produced by Alternaria fungi, as well as their occurrences, biological activities and functions. Some considerations related to synthesis, biosynthesis, production and applications of the metabolites from Alternaria fungi are also discussed.

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“…A dibenzofuran derivative porric acid D ( 160 ) and altenusin ( 161 ) were isolated from the methanol extract of the marine derived fungus, Alternaria sp., isolated from the Bohai Sea. These compounds were reported to have antibacterial activity against S. aureus [ 90 ]. Several small molecules including p -hydroxybenzoic acid ( 162 ), trans -cinnamic acid ( 163 ) and N -hydroxybenzoisoxazolone ( 164 ) were isolated from Pseudoalteromonas flavipulchra and showed antibacterial activity against Vibrio anguillarum .…”

Section: Miscellaneous Compoundsmentioning

confidence: 99%

Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials

et al. 2017

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The marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in organic synthesis and chemical structure elucidation, have accelerated the numbers of antimicrobial molecules originating from the ocean moving into clinical trials. The chemical diversity associated with these marine-derived molecules is immense, varying from simple linear peptides and fatty acids to complex alkaloids, terpenes and polyketides, etc. Such an array of structurally distinct molecules performs functionally diverse biological activities against many pathogenic bacteria and fungi, making marine-derived natural products valuable commodities, particularly in the current age of antimicrobial resistance. In this review, we have highlighted several marine-derived natural products (and their synthetic derivatives), which have gained recognition as effective antimicrobial agents over the past five years (2012–2017). These natural products have been categorized based on their chemical structures and the structure-activity mediated relationships of some of these bioactive molecules have been discussed. Finally, we have provided an insight into how genome mining efforts are likely to expedite the discovery of novel antimicrobial compounds.

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Porric acid D from marine-derived fungus Alternaria sp. isolated from Bohai Sea

Cited by 17 publications

References 7 publications

Marine natural products

Marine natural products

Metabolites from Alternaria Fungi and Their Bioactivities

Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials

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