This paper builds a taxonomy of European regions based on their integration in international markets. The classification is based on two dimensions, one structural/functional, the structural connectivity of regions, and another purely economic, their degree of specialization in open sectors. The conceptual classification is empirically applied to all European regions at Nuts 2 level, which are accordingly classified into three types depending on their role in globalization: global players; regional players; and local players. Based on the taxonomy, the paper presents the reasons behind the special issue and the choice of the regions to be investigated, and an ex-ante appraisal of them through macroeconomic statistics. Finally, the paper also illustrates the research questions to which each of the following papers is bound to provide a reply.JEL classification: R10, R11, F15, R58