Portable 24-analyte surface plasmon resonance instruments for rapid, versatile biodetection

Chinowsky, Timothy M.; Soelberg, Scott D.; Baker, Paul R. S.; Swanson, Nathaneal R.; Kauffman, Peter; Mactutis, Anthony; Grow, Michael S.; Atmar, Robert L.; Yee, Sinclair S.; Furlong, Clement E.

doi:10.1016/j.bios.2006.11.026

Cited by 134 publications

(53 citation statements)

References 24 publications

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“…This change in refractive index is measured in real time, and the result is plotted as response or resonance units (RUs) versus time (a sensorgram) 25 . The miniature SPR sensing chip, described by Soelberg 26 , et al and Chinowsky 27,28 , et al, is a fully integrated SPR sensor element. Its main components ( Fig.…”

Section: Gold Nanoparticle-enhanced Surface-plasmonmentioning

confidence: 99%

Nanoparticle-based Sensors

Khanna

2008

DSJ

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Nanoparticles exhibit several unique properties that can be applied to develop chemical and biosensors possessing desirable features like enhanced sensitivity and lower detection limits. Gold nanoparticles are coated with sugars tailored to recognise different biological substances. When mixed with a weak solution of the sugar-coated nanoparticles, the target substance, e.g., ricin or E.coli, attaches to the sugar, thereby altering its properties and changing the colour. Spores of bacterium labeled with carbon dots have been found to glow upon illumination when viewed with a confocal microscope. Enzyme/nanoparticle-based optical sensors for the detection of organophosphate (OP) compounds employ nanoparticle-modified fluorescence of an inhibitor of the enzyme to generate the signal for the OP compound detection. Nanoparticles shaped as nanoprisms, built of silver atoms, appear red on exposure to light. These nanoparticles are used as diagnostic labels that glow when target DNA, e.g., those of anthrax or HIV, are present. Of great importance are tools like gold nanoparticle-enhanced surface-plasmon resonance sensor and silver nanoparticle surface-enhanced portable Raman integrated tunable sensor. Nanoparticle metal oxide chemiresistors using micro electro mechanical system hotplate are very promising devices for toxic gas sensing. Chemiresistors comprising thin films of nanogold particles, encapsulated in monomolecular layers of functionalised alkanethiols, deposited on interdigitated microelectrodes, show resistance changes through reversible absorption of vapours of harmful gases. This paper reviews the state-of-the-art sensors for chemical and biological terror agents, indicates their capabilities and applications, and presents the future scope of these devices.

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Section: Gold Nanoparticle-enhanced Surface-plasmonmentioning

confidence: 99%

Nanoparticle-based Sensors

Khanna

2008

DSJ

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“…Attempts to integrate SPR biosensor apparatus, in order to reduce size and cost, have been proposed, like the use of: polymer-based prisms, using packaged (Chinowsky et al, 2003;Chinowsky et al, 2007;Elkind et al, 1999) or non-packaged arrangements (Loureiro et al, 2009;Loureiro et al, 2011;Moreira et al, 2009 andThirstrup et al, 2004), conventional (Cennamo et al 2013) and microstructured (Dash and Jha, 2014) optical fibers, silicon-based devices (Ghosh andRay, 2015 andPatskovsky et al, 2003) and nanoparticles-based devices (Atar et al, 2015;Rivero et al, 2012;Sener et al, 2011 andWillets andVan Duyne, 2007). For the nanoparticles-based devices the associated physics is different than SPR physics and the phenomenon is known as Localized SPR or LSPR.…”

Section: Theoretical Aspectsmentioning

confidence: 99%

Polymer-based surface plasmon resonance biochip: construction and experimental aspects

et al. 2016

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Introduction: Surface plasmon resonance biosensors are high sensitive analytical instruments that normally employ glass materials at the optical substrate layer. However, the use of polymer-based substrates is increasing in the last years due to favorable features, like: disposability, ease to construction and low-cost design. Review: Recently, a polymer-based SPR biochip was proposed by using monochromatic and polychromatic input sources. Its construction and experimental considerations are detailed here. Experimental considerations and results, aspects from performance characteristics (resonance parameters, sensitivity and full width at half maximum -FWHM -calculations) are presented for hydrophilic and hydrophobic solutions. It is included also a brief description of the state of the art of polymer-based SPR biosensors.

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“…Companies such as Texas Instrument (Spreeta) [4,5], K-MAC (Biochip Analyzer, SPRmicro), Seattle Sensor Systems (SPIRIT) [6], and Möbius advanced technology (handheld SPR) currently market portable instruments. The RI resolution of portable instruments is of the order of~2×10 −6 refractive index units (RIU), in comparison with~2×10 −7 RIU [6][7][8] for a high-performance laboratory SPR instrument. The RI resolution refers to the smallest change in RI that it is possible to monitor.…”

mentioning

confidence: 99%

“…In the last decade, portable SPR devices have been used for detection of analytes ranging from small to large molecules or bacteria [6]. Because of the small change in effective refractive index of small molecules, a competitive immunoassay is usually performed to enhance the SPR response and detect these molecules (Fig.…”

mentioning

confidence: 99%

Nanostructured substrates for portable and miniature SPR biosensors

Breault-Turcot

Masson

2012

Anal Bioanal Chem

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Surface plasmon resonance (SPR) biosensing has matured into a valuable analytical technique for measurements related to biomolecules, environmental contaminants, and the food industry. Contemporary SPR instruments are mainly suitable for laboratory-based measurements. However, several point-of-measurement applications would benefit from simple, small, portable and inexpensive sensors to assess the health condition of a patient, potential environmental contamination, or food safety issues. This Trend article explores nanostructured substrates for improving the sensitivity of classical SPR instruments and nanoparticle (NP)-based colorimetric substrates that may provide a solution to the development of point-of-measurement SPR techniques. Novel nanomaterials and methodology capable of enhancing the sensitivity of classical SPR sensors are destined to improve the limits of detection of miniature SPR instruments to the level required for most applications. In a different approach, paper or substrate-based SPR assays based on NPs, are a highly promising topic of research that may facilitate the widespread use of a novel class of miniature and portable SPR instruments.

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Portable 24-analyte surface plasmon resonance instruments for rapid, versatile biodetection

Cited by 134 publications

References 24 publications

Nanoparticle-based Sensors

Nanoparticle-based Sensors

Polymer-based surface plasmon resonance biochip: construction and experimental aspects

Nanostructured substrates for portable and miniature SPR biosensors

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