We describe how current radiological best practices are predicated on a sophisticated technological ecosystem usually comprised of multiple large-scale displays, and integrated record keeping and communication systems driven by high-speed networks. At the same time, current development of low-cost ultrasound (U/S) devices for lowresource settings trends towards small-scale, independent devices with palm-sized screens. We reviewed existing literature, analyzed findings from two years of fieldwork in Uganda, and conducted an interview study with clinicians about radiology work practices to determine which patterns and technologies contribute to the efficacy of ultrasound. We use these findings to inform how ultrasound technology in low-resource settings can most usefully be developed and deployed. In addition, findings are relevant for creating medical technologies for low-resource environments generally, as we make clear the importance of considering not just technology development aspects like power consumption and interface, but also larger technology and work ecosystems.There is a growing interest in how low-cost medical technologies can be developed and deployed in lowresource settings to improve global health indicators. Tools such as low-cost, point-of-care technologies (e.g. microfluidic diagnostic systems [35], mobile phone based microscopes [4], and phone-based cough detection [17]) have inspired new research approaches and interdisciplinary research communities. This global health research community shares many of its approaches with the information and communication technologies for development (ICTD) field, an emerging area of research focused on using computer-based solutions to address problems facing developing regions and underserved populations, including problems associated with collaborative practices in the workplace. In addition to healthcare applications, ICTD projects focus on a wide variety of problem spaces, such as education, agriculture, microfinance, and transportation [1,11,18,24,33]. Many lessons have been drawn from the successes and failures of ICTD research, most of which emphasize the importance of creating and deploying technologies that recognize the physical settings in which people live and work [2,7,20]. For example, ICTD researchers have identified a common set of design and computing constraints such as cost, low power, low connectivity, low literacy, multiple or marginalized languages, and accessibility challenges [12].In addition to design issues focused on technological artifacts, researchers in the ICTD community have also learned to design with a focus on people and diverse usage contexts. Such work tends to be informed by social construction of technology and appropriate technology literature [26,13]. Appropriate technology literature advocates for design that meets ethical, cultural, social, political and economic standards in the community for which it is intended. Leveraging existing systems, processes, and resources rather than trying to introduce radically new on...