Portable blood extraction device integrated with biomedical monitoring system

Khumpuang, Sommawan; Horade, Mitsuhiro; Fujioka, K.; Saito, Susumu

doi:10.1117/12.638589

Cited by 3 publications

(2 citation statements)

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“…Changes in the K þ ion concentration in human serum increases the risk of acute cardiac arrhythmia, and changes in the Na þ ion concentration in human blood increases the risk of kidney failure. 1,2 Besides the aforementioned applications in the biomedical field, the measurement of the K þ and Na þ ions concentrations is also important for food and wine quality testing and water pollution monitoring in the industrial and environmental fields. [3][4][5] Ion sensitive field-effect transistors (ISFETs) have attracted interest recently because of their great potential as label-free, realtime, and in vivo sensors.…”

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confidence: 99%

Characterization of K+ and Na+-Sensitive Membrane Fabricated by CF4 Plasma Treatment on Hafnium Oxide Thin Films on ISFET

Yang²,

Wang

et al. 2011

J. Electrochem. Soc.

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In this paper, we report the effects of fluorine incorporation on the alkali ion sensing properties of a HfO 2 dielectric material. The fluorinated-HfO 2 film prepared by the postdeposition CF 4 plasma treatment was used as a sensing layer of ion sensitive field-effect transistors (ISFET) for K þ and Na þ ion detection. The fluorinated-HfO 2 gate ISFET is sensitive to K þ (25.86 mV/M) and Na þ (33.77 mV/M) ions for both in the concentration range between 3 and 135 mM. In comparison with the same structure without plasma treatment, the sensitivity was improved fivefold, and lower selectivity coefficients of K þ and Na þ ions against H þ ion were obtained. In the stability test, the result of time-dependent drift measurements showed that this low power plasma process could not degrade the sensing performance, and lifetime evaluated based on analysis sensitivity change in time was over 15 months. The chemical states of the HfO 2 film after CF 4 plasma treatment were examined by x-ray photoelectron spectroscopy. Analysis of the spectra of F 1s, O 1s, and Hf 4f showed that the fluorine atoms are incorporated into the HfO 2 film. This fluorinated-HfO 2 film fabricated by inorganic CF 4 plasma is compatible with advanced complementary metal oxide semiconductor technology and possible biosensor applications.

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confidence: 99%

Characterization of K+ and Na+-Sensitive Membrane Fabricated by CF4 Plasma Treatment on Hafnium Oxide Thin Films on ISFET

Yang²,

Wang

et al. 2011

J. Electrochem. Soc.

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“…Khumpuang et al reported a blood-extraction device integrated with an electrolytemonitoring system. 15 This device can precisely control the dosage of extracted blood. A novel blood-extraction system realized by assembling a high-aspect-ratio microneedle in a polydimethylsiloxane elastic self-recovery actuator was proposed.…”

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confidence: 99%

Polymer-based disposable microneedle array with insertion assisted by vibrating motion

Lee

Hung

et al. 2016

Biomicrofluidics

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This work presents a disposable polymer-based microneedle array that carries out insertions by mimicking the vibrating motion of a mosquito's proboscis. The proposed device, which comprises a 10:1 high-aspect-ratio parylene microneedle array and a chamber structure, was monolithically realized using a novel fabrication process. The vibrating motion of the microneedles was generated using a piezoelectric actuator. This device can be potentially applied to extract and collect blood by puncturing the dermis layer of human skin. The fabricated device is advantageous because of its biocompatibility, simple fabrication process, and low associated costs. Additionally, the graph of the measured extraction flow rate versus the pressure drop that is presented shows an agreement with the results predicted by analytical models. A 40% reduction of insertion force was demonstrated when the microneedle insertion was assisted by actuator-induced vibratory motions. Buckling analyses for estimating the maximum loads that the microneedle can sustain before failure occurs were also evaluated. Finally, the relationship between the insertion force and the vibration frequency was demonstrated in this study. V C 2016 AIP Publishing LLC. [http://dx

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A disposable parylene microneedle array for blood extraction assisted by vibrating motion for insertions

Lee

Hung

et al. 2016

2016 IEEE 29th International Conference on Micro Electro Mechanical Systems (MEMS)

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Portable blood extraction device integrated with biomedical monitoring system

Cited by 3 publications

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Characterization of K+ and Na+-Sensitive Membrane Fabricated by CF4 Plasma Treatment on Hafnium Oxide Thin Films on ISFET

Characterization of K+ and Na+-Sensitive Membrane Fabricated by CF4 Plasma Treatment on Hafnium Oxide Thin Films on ISFET

Polymer-based disposable microneedle array with insertion assisted by vibrating motion

A disposable parylene microneedle array for blood extraction assisted by vibrating motion for insertions

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