Portable Device for Express Assessment of Functional State of Hemostasis System

Zhukov, E. L.; Gubarev, Fedor A.; Tyutrin, I. I.; Dyachenko, Yuliya V.

doi:10.1109/edm49804.2020.9153534

Cited by 1 publication

(2 citation statements)

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“…In this figure the time response of the RGBGs channels at three different magnifications is illustrated for the whole experimental period. In all cases, there is an increase in the average detected light until approximately the 10th minute, most probably due to the phenomenon of RBCA, in combination with the initial stages of fibrin formation [ 31 ]. After RBCA reaches a maximum and any cell movement has ceased, blood coagulation is the dominant process affecting blood microstructure.…”

Section: Resultsmentioning

confidence: 99%

“…To accommodate the blood sample to be processed, simple microfluidic configurations are often used, offering several advantages [ 27 , 28 , 29 , 30 ]. Other techniques, such piezocoagulography, have been also utilized for blood coagulation, showing also the possibility of studying the initial stage of fibrin formation in the clotting process [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Development of an Optical Method for the Evaluation of Whole Blood Coagulation

Louka

Kaliviotis

2021

Biosensors

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Blood coagulation is a defense mechanism, which is activated in case of blood loss, due to vessel damage, or other injury. Pathological cases arise from malfunctions of the blood coagulation mechanism, and rapid growth of clots results in partially or even fully blocked blood vessel. The aim of this work is to characterize blood coagulation, by analyzing the time-dependent structural properties of whole blood, using an inexpensive design and robust processing approaches. The methods used in this work include brightfield microscopy and image processing techniques, applied on finger-prick blood samples. The blood samples were produced and directly utilized in custom-made glass microchannels. Color images were captured via a microscopy-camera setup for a period of 35 min, utilizing three different magnifications. Statistical information was extracted directly from the color components and the binary conversions of the images. The main advantage in the current work lies on a Boolean classification approach utilized on the binary data, which enabled to identify the interchange between specific structural elements of blood, namely the red blood cells, the plasma and the clotted regions, as a result of the clotting process. Coagulation indices produced included a bulk coagulation index, a plasma-reduction based index and a clot formation index. The results produced with the inexpensive design and the low computational complexity in the current approach, show good agreement with the literature, and a great potential for a robust characterization of blood coagulation.

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Section: Resultsmentioning

confidence: 99%