Portable Environmental Microfluidic Chips with Colorimetric Sensors: Image Recognition and Visualization

Kim, Hyeon-Gyu; Yu, Yang; Yang, Yooyeol; Park, Myoung‐Hwan

doi:10.1007/s13530-019-0419-z

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…NIR light is capable of deep tissue penetration and is safe for cells and tissues. Given their strong absorption capacity for light in the NIR range (650–900 nm), gold nanorods (GNRs) can generate heat through surface plasmon resonance (SPR) and stimulate the release of drugs from the CSNF scaffold. ,− …”

Section: Introductionmentioning

confidence: 99%

Smart Delivery Platform Using Core–Shell Nanofibers for Sequential Drug Release in Wound Healing

Singh

Kim

Shukla

et al. 2023

ACS Appl. Bio Mater.

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An effective approach to accelerating wound healing is through a smart delivery platform that releases drugs according to the needs of different healing periods. With the growing demand for wound care and treatment, electrospun nanofibers have attracted considerable attention owing to their simple and versatile method of manufacturing, unique structure, and biological functions similar to those of the extracellular matrix. Moreover, nanofibers can be loaded with active substances that promote targeted wound healing. In this study, we investigated the performance of a core–shell nanofiber platform loaded with two drugs in the core and shell, respectively. The shell polymer, poly-l-lactic acid, initially releases the encapsulated drug into an aqueous solution at room temperature. Gold nanorods with near-infrared absorbance were incorporated in the core polymer poly(N-isopropylacrylamide) to produce localized heat by plasmon resonance when exposed to light. This allows the thermally responsive core polymer to swell and shrink for programmable drug release. Our study provides a versatile platform for controlled and safe drug delivery to wound sites and could be applied to the treatment of other topical diseases.

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Section: Introductionmentioning

confidence: 99%

Smart Delivery Platform Using Core–Shell Nanofibers for Sequential Drug Release in Wound Healing

Singh

Kim

Shukla

et al. 2023

ACS Appl. Bio Mater.

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“…Using controlled and sequenced release mechanisms to prevent undesirable outcomes associated with simultaneous codelivery, local DDSs can restrict drug–drug interactions, improve therapeutic effectiveness, and minimize drug resistance in skin cancer treatment. − The field of sequential and on-demand DDSs has seen a growth in the development of responsive biomaterials with configurable physical and chemical characteristics. − Because of their reversible phase transformation in reaction to stimulation and physiochemical influences such as pH, temperature, and enzymatic activity, and external forces such as UV light, near-infrared (NIR), ultrasound, electric, and magnetic radiation, these materials can be used as drug-carrier frameworks for the effective delivery of pharmaceuticals. − Because most drugs must be given repeatedly and consistently over long periods of time to be effective, and their concentrations must remain within the desired effective range to prevent overuse or underdosing, it is necessary to develop and improve new adaptive systems that can be easily controlled externally and capable of being spatially programmed. ,, …”

Section: Introductionmentioning

confidence: 99%

Light-Responsive Layer-By-Layer Film Containing Gold Nanorods for Sequential Drug Release

Singh,

Chejara,

Park

2023

ACS Omega

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Chemically and physically stable multidrug-loaded layer-by-layer (LbL) films are promising candidates for sequential and on-demand drug release at concentrations suitable for various applications. The synergistic effect of the sequential release of drugs may enhance their therapeutic efficacy in treating skin cancer and other complex medical conditions. In this study, we prepared LbL films by alternating the deposition of cationic linear polyethylenimine, camptothecin (CPT)-loaded gold nanorods (GNRs), anionic poly(styrenesulfonate), and doxorubicin (DOX) based on electrostatic interactions. The film exhibited loading of CPT and DOX, which could be tuned according to the requirements of the application by changing the parameters of the LbL process. Herein, CPT was encapsulated in GNRs and showed good stability and absorption in the near-infrared (NIR) range (650–900 nm). The prepared LbL film showed a pH-dependent DOX release. Subsequently, the functionalized GNRs showed excellent photothermal properties, which assisted the on-demand release of CPT upon NIR irradiation with further release of DOX. Our results suggest that the LbL approach for sequential drug release can be an effective drug delivery platform owing to its cytocompatibility, anticancer effects, and stimuli-responsive properties.

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“…Plasmonic nanoparticles are metallic atom-based nanomaterials that display oscillations in the electron density in response to particular light frequencies. − They are capable of generating heat from light in the NIR region of the spectrum. Among them, gold nanorods (GNRs) have drawn interest because the aspect ratio enables fine-tuning the range of light absorption, allowing for precise control of heating efficiency .…”

Section: Introductionmentioning

confidence: 99%

On-Demand Drug-Delivery Platform Using Electrospun Nanofibers by Externally Triggered Glass Transition Switch

Kim

Singh

Shukla

et al. 2022

ACS Materials Lett.

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On-demand drug-delivery platforms can provide precise control over the timing and amount of drug delivered using external stimuli. Such platforms enable customizable release patterns and enhance therapeutic efficacy by anticipatorily, repeatedly, and dependably controlling the timing, amount, and location of drug release. Herein, we propose an innovative on-demand drug release platform based on electrospun nanofibers (NFs) with a near-infrared (NIR)-triggered glass transition switch to simplify protocols and improve the currently available thermoresponsive nanocarrier formulations. The gold nanorods (GNRs) present in NFs generate heat when exposed to NIR radiation due to the plasmon resonance effect as the GNRs are absorbed in the range of the NIR spectrum. In this investigation, poly-L-lactic acid, a polymer with a glass transition temperature (T g ) of 53−58 °C, was used to create electrospun NFs containing GNRs and camptothecin. Upon NIR irradiation, the increase in temperature above the T g by the GNRs caused physical changes in the NFs, which ensured that the drug was released in a controlled manner. This study demonstrates a promising platform for safely delivering drugs and controlling drug release to treat cancer as well as other challenging diseases.

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Portable Environmental Microfluidic Chips with Colorimetric Sensors: Image Recognition and Visualization

Cited by 9 publications

References 21 publications

Smart Delivery Platform Using Core–Shell Nanofibers for Sequential Drug Release in Wound Healing

Smart Delivery Platform Using Core–Shell Nanofibers for Sequential Drug Release in Wound Healing

Light-Responsive Layer-By-Layer Film Containing Gold Nanorods for Sequential Drug Release

On-Demand Drug-Delivery Platform Using Electrospun Nanofibers by Externally Triggered Glass Transition Switch

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