Portal and Mesenteric Vein Thrombosis Secondary to Cytomegalovirus Hepatitis

Annicchérico-Sánchez, Francisco Javier; Alonso-Martínez, José Luis; Urbieta-Echezarreta, Miren Aránzazu

doi:10.1016/s0953-6205(11)60021-6

Cited by 1 publication

(2 citation statements)

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“…The association between CMV and MGUS (table 1) has been demonstrated previously in cohort studies with immunodeficient patients 9–17. Reports on this phenomenon in immunocompetent individuals are scarce and limited to three case reports and one small cohort study 18–21. In this cohort study, 10 out of 25 (40%) immunocompetent patients with acute CMV infection developed concurrent MGUS, compared with none in a control group consisting of patients with acute EBV infection 21.…”

Section: Discussionsupporting

confidence: 61%

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Cytomegalovirus infection with pulmonary embolism, splenic vein thrombosis and monoclonal gammopathy of undetermined significance: a case and systematic review

et al. 2019

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A 62-year-old immunocompetent woman was admitted with cytomegalovirus (CMV) infection, pulmonary embolism, splenic vein thrombosis and monoclonal gammopathy of undetermined significance (MGUS). Anticoagulation therapy was started. Two months later, seroconversion of CMV IgM to IgG was observed, while the monoclonal protein was no longer detectable. This suggests a relationship between acute CMV infection, transient MGUS and thrombosis. In accordance with current best practice guidelines for provoked venous thromboembolism (VTE), anticoagulation therapy could be discontinued after 3 months instead of 6 for unprovoked VTE, thereby reducing unnecessary time at risk of bleeding complications. While the relationships between CMV and both MGUS and thrombosis have been described independently, we are first to describe these three conditions occurring simultaneously.Furthermore, we provide a systematic review on the relation between CMV, MGUS and thrombosis.

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Section: Discussionsupporting

confidence: 61%

“…This concerned a hypergammaglobulinaemia with monoclonality of IgM lambda, IgG kappa and IgG lambda and is therefore not comparable with our case. Apart from one confined case report in a meeting abstract,19 VTE was not present in any of these articles.…”

Section: Discussionmentioning

confidence: 96%