Portal blood flow via the peribiliary vascular plexus demonstrated by contrast‐enhanced ultrasonography with Sonazoid

Uchikawa, Yuji; Kitamura, Hiroshi; Miyagawa, Shinichi

doi:10.1007/s00534-011-0380-y

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…There are more and more studies on the influence of microcirculation on vascular epithelial cells in recent years, and it can be inferred that microcirculation disturbance will have a continuous impact on vascular epithelial cells. In this study, the effect of intrahepatic microcirculation disturbance of PVP on epithelial cells after liver transplantation was studied based on the establishment of an animal model of liver transplantation in rats (5).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Microcirculation Disturbance of Peribiliary Vascular Plexus on Hepatic Bile Duct Epithelial Cells in Rats Undergoing Liver Transplantation and Postoperative Rejection Reduction by Nanocarrier Mediation

Yuan¹,

Zhou²,

Deng³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Peribiliary vascular plexus (PVP), hepatic bile duct (HBD), ribose nucleic acid (RNA), class-II transactivator (CIITA), deoxyribonucleic acid (DNA), histidinegrafted poly (-amino ester) (HGPAE), proliferating cell nuclear antigen (PCNA), cytokeratin 19 (CK-19), human factor VIII antigen (F-VIII-Ag), vascular endothelial growth factor A (VEGFA), vascular endothelial growth factor B (VEGFB), and vascular endothelial growth factor C (VEGFC), hepatic artery ligation (HAL), hepatic artery microsphere injection (HAMI), small hairpin RNA (shRNA)

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Section: Introductionmentioning

confidence: 99%

The Effect of Microcirculation Disturbance of Peribiliary Vascular Plexus on Hepatic Bile Duct Epithelial Cells in Rats Undergoing Liver Transplantation and Postoperative Rejection Reduction by Nanocarrier Mediation

Yuan¹,

Zhou²,

Deng³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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“…Approximately 15 min after the injection, perflubutane is absorbed by the Kupffer cells in the normal liver tissues and reflects ultrasound waves; thus, a contrast is created between the normal tissues and tumor tissues that do not contain Kupffer cells (Kupffer phase). Contrast‐enhanced ultrasonography with perflubutane is reported to have diagnostic capability similar to that of contrast‐enhanced CT in the differential diagnosis of liver tumors and detection of small liver lesions []. Thus, ultrasonography may be useful for the demonstration of metastatic lesions reduced by chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Fate of metastatic foci after chemotherapy and usefulness of contrast‐enhanced intraoperative ultrasonography to detect minute hepatic lesions

Uetake

Tanaka

Ishikawa

et al. 2012

J Hepato Biliary Pancreat

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Background/purpose Along with advances in the chemotherapy for colorectal cancer, the strategy for hepatic metastasis has been changed. One of the most striking issues is that initially unresectable hepatic metastases can be resectable after chemotherapy with considerably high frequency. In addition, advanced chemotherapy leads to the downsizing of the metastatic foci in the liver, which is sometimes difficult to detect with conventional intraoperative ultrasonography (IOUS). To discover the undetectable hepatic lesions with IOUS, we have introduced contrastenhanced intraoperative ultrasonography (CEIOUS). In the present study, we present evidence that viable cancer cells exist in even the shrunken tumors with high frequency and that CEIOUS contributes to detecting the minute foci. Methods This study was composed of eight patients; four of them had initially unresectable metastasis, and the remaining four had either H2 or H3 status of hepatic metastases. All of them underwent hepatic resection after chemotherapy. Results A total of 57 metastatic lesions were detected before chemotherapy. Thirty lesions were demonstrated by CEIOUS with perflubutane and resected. In the pathological examination, tumor cells were not found in 12 of the 30 resected lesions. The degree of pathological liver damage was grade 1 or less in all patients, and no serious complication occurred after surgery in any of the patients. Conclusion The present study showed that viable cancer cells remained with high frequency, even in the minute hepatic metastasis which was reduced in size after chemotherapy, and CEIOUS was a useful examination for detecting the minute hepatic foci.

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Vascular Anatomy and Its Implication in Radioembolization

Saiz-Mendiguren

Arias

Vivas

et al. 2013

Liver Radioembolization With 90Y Microspheres

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Portal blood flow via the peribiliary vascular plexus demonstrated by contrast‐enhanced ultrasonography with Sonazoid

Abstract: This is the first report of blood flow via the PBP in human liver visualized by dynamic image study.

Cited by 4 publications

References 14 publications

The Effect of Microcirculation Disturbance of Peribiliary Vascular Plexus on Hepatic Bile Duct Epithelial Cells in Rats Undergoing Liver Transplantation and Postoperative Rejection Reduction by Nanocarrier Mediation

The Effect of Microcirculation Disturbance of Peribiliary Vascular Plexus on Hepatic Bile Duct Epithelial Cells in Rats Undergoing Liver Transplantation and Postoperative Rejection Reduction by Nanocarrier Mediation

Fate of metastatic foci after chemotherapy and usefulness of contrast‐enhanced intraoperative ultrasonography to detect minute hepatic lesions

Vascular Anatomy and Its Implication in Radioembolization

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