Portal Hypertension After Bile Duct Obstruction

Influence of biliary anastomosis on recovery from secondary biliary cirrhosis

“…The excluded loop of the Roux-en-Y, despite having 15 cm of extension (proportionally corresponding to 40 cm in humans), was not enough to avoid the reflux and the stasis. These findings may be the cause of the transitory episodes of cholestasis and cholangitis described previously in humans [39] and experimental models [10,11], which contradicts the common belief that a wide and pervious anastomosis is enough to ensure the resolution of BO without additional problems [6,40,41].…”

“…However, rats exposed to 3 or 4 weeks of BO and treated with CD or CJ showed a regression in the fibrosis, but not a correction of the portal hypertension [6,10,30]. The reason for the delay in the repair of the portal pressure, despite fibrosis regression, is not clear.…”

“…However, few reports have evaluated the effects of biliodigestive anastomosis on the regression of the hepatic lesions in these models of chronic extrahepatic BO [6,7,10,30]. Studies comparing these conditions in the long term, evaluation of CD and CJ performance, and the possible effects of these treatments on the liver and the biliary ducts are rare [8].…”

“…The use of CD in rats with secondary biliary fibrosis leads to the resolution of cholestasis, but without recovery of anatomopathological lesions and portal hypertension [10].…”

The Roles of Angiotensin II Receptors in the Portosystemic Collaterals of Portal Hypertensive and Cirrhotic Rats

“…Surgery and hemodynamic studies were performed under ketamine hydrochloride anesthesia (100 mg/kg; i.m.). Portal hypertension was induced by partial portal vein ligation (PVL) [14] and liver cirrhosis by common bile duct ligation (BDL) [15,16,17], respectively. Corresponding sham groups received sham operations without ligations and were treated in the same way.…”