Portal vein omentin is increased in patients with liver cirrhosis but is not associated with complications of portal hypertension

Eisinger, Kristina; Krautbauer, Sabrina; Wiest, Reiner; Karrasch, Thomas; Hader, Yvonne; Scherer, Marcus N.; Farkas, S.; Aslanidis, Charalampos; Buechler, Christa

doi:10.1111/eci.12122

Cited by 21 publications

(27 citation statements)

References 36 publications

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“…Therefore, higher serum omentin levels in cirrhotic patients with increased IR is an unexpected finding. However, our results are in accordance with results obtained by Eisinger et al[19], who found omentin serum levels to be significantly decreased in cirrhotic patients with better insulin sensitivity.…”

Section: Discussionsupporting

confidence: 94%

“…Prothrombin is a key factor in clot formation, and elevated levels appear to promote venous thrombosis. In the study by Eisinger et al[19], omentin levels were significantly higher in the portal vein. In addition, these levels tended to be higher in the hepatic vein and systemic blood of patients with liver cirrhosis compared with the respective blood compartments of control patients with healthy livers.…”

Section: Discussionmentioning

confidence: 95%

“…However, the role of omentin in CLD is unclear. A small number of studies have shown that omentin serum are levels increased in CHC, NAFLD and cirrhosis[14,18,19]. …”

Section: Introductionmentioning

confidence: 99%

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Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis

Kukla

Waluga

Żorniak

et al. 2017

WJG

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AIMTo investigate serum omentin and vaspin levels in cirrhotic patients; and to assess the relationship of these levels with hemostatic parameters, metabolic abnormalities, cirrhosis severity and etiology.METHODSFifty-one cirrhotic patients (17 with portal vein thrombosis) were analyzed. Serum omentin and vaspin levels were measured with commercially available direct enzyme-linked immunosorbent assays (ELISAs). To assess platelet activity, the following tests were performed using a MULTIPLATE®PLATELET FUNCTION ANALYZER: (1) an ADP-induced platelet activation test; (2) a cyclooxygenase dependent aggregation test (ASPI test); (3) a von Willebrand factor and glycoprotein Ib-dependent aggregation (using ristocetin) test (RISTO test); and (4) a test for thrombin receptor-activating peptide-6 induced activation of the thrombin receptor, which is sensitive to IIb/IIIa receptor antagonists.RESULTSOmentin, but not vaspin, serum concentrations were significantly decreased in patients with portal vein thrombosis (PVT) (P = 0.01). Prothrombin levels were significantly increased in patients with PVT (P = 0.01). The thrombin receptor activating peptide (TRAP) test results were significantly lower in the PVT group (P = 0.03). No significant differences in adipokines serum levels were found regarding the etiology or severity of liver cirrhosis assessed according to the Child-Pugh or Model of End-Stage Liver Disease (MELD) scores. There was a significant increase in the TRAP (P = 0.03), ASPI (P = 0.001) and RISTO high-test (P = 0.02) results in patients with lower MELD scores. Serum omentin and vaspin levels were significantly down-regulated in patients without insulin resistance (P = 0.03, P = 0.02, respectively). A positive relationship between omentin and vaspin levels were found both when all of the patients were analyzed (r = 0.41, P = 0.01) and among those with PVT (r = 0.94, P < 0.001).CONCLUSIONSerum omentin levels are increased in patients without PVT. Cirrhosis origin and grade do not affect omentin and vaspin levels. The analyzed adipokines do not influence platelet activity.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 95%

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Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis

Kukla

Waluga

Żorniak

et al. 2017

WJG

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“…Cirrhotic patients had higher portal vein omentin levels, which also were increased in systemic venous serum compared with controls, but there was no association with portal hypertension complications [43]. The main cause of cirrhosis in those patients was alcoholic hepatitis, with only three out of 34 having cirrhosis as a result of CHC.…”

Section: Discussionmentioning

confidence: 84%

Omentin serum concentration and hepatic expression in chronic hepatitis C patients – together or apart?

Kukla¹,

Waluga²,

Adamek³

et al. 2015

pjp

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Chronic hepatitis C (CHC) is accompanied by numerous metabolic disorders, partially associated with altered adipokine system regulation. Omentin (intelectin-1) is a novel adipokine known to play a pivotal role in metabolic regulation in CHC. In a group of 63 CHC patients (29 men/34 women) infected with genotype 1b, aged 6.6 ±14.6 years, serum omentin levels and its gene expression in liver tissue were examined and their association with metabolic and histopathological features was assessed. Serum omentin levels were significantly higher in CHC patients compared to controls (p < 0.001), regardless of sex, body mass index (BMI), insulin sensitivity and lipid concentrations. There was no correlation between serum omentin and omentin hepatic expression. Neither parameter was associated with any histological features. Serum omentin in non-obese CHC patients seems not to be related to metabolic disorders or liver pathology. Omentin hepatic expression shows no relationship with either serum omentin levels or histopathological features. This suggests different mechanisms regulating circulating omentin concentration and omentin hepatic expression in CHC.

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“…During TIPS implantation, samples were obtained simultaneously of one of the hepatic veins (HVS) which was not drained by the TIPS-stent, of the portal vein (PVS) and of a peripheral vein such as the superior caval vein (SVS). Patient samples analyzed herein have been used in previous studies [23][24][25][26]. …”

Section: Transjugular Intrahepatic Portosystemic Shunt (Tips)mentioning

confidence: 99%

Circulating lipocalin 2 is neither related to liver steatosis in patients with non-alcoholic fatty liver disease nor to residual liver function in cirrhosis

et al. 2016

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Portal vein omentin is increased in patients with liver cirrhosis but is not associated with complications of portal hypertension

Abstract: Current data show that PVS omentin is increased in liver cirrhosis but is not associated with complications of portal hypertension.

Cited by 21 publications

References 36 publications

Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis

Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis

Omentin serum concentration and hepatic expression in chronic hepatitis C patients – together or apart?

Circulating lipocalin 2 is neither related to liver steatosis in patients with non-alcoholic fatty liver disease nor to residual liver function in cirrhosis

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