Portal Vein Thrombosis Associated With Cirrhosis

Sarfeh, I. James

doi:10.1001/archsurg.1979.01370320034006

Cited by 55 publications

(37 citation statements)

References 11 publications

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“…In their report the incidence of portal vein thrombosis among the patients with Child C cirrhosis was 1.3% and that of patients after splenectomy was 22.2%. The highest incidence of 21% was reported by Sarfeh (11). In this report all of the 86 patients had had bleedings from esophageal varices and underwent portal decompression surgery after portography.…”

Section: Discussionmentioning

confidence: 52%

The incidence of portal vein thrombosis at liver transplantation

Nonami

1992

Hepatology

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Section: Discussionmentioning

confidence: 52%

The incidence of portal vein thrombosis at liver transplantation

Nonami

1992

Hepatology

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“…The highest incidence of 21 % was reported by Sarfeh (11). In this report all of the 86 patients had had bleedings from es()phageal varices and underwent portal decompression surgery after portography.…”

Section: Discussionmentioning

confidence: 53%

The Incidence of Portal Vein Thrombosis At Liver Transplantation

et al. 1992

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The incidence of portal vein thrombosis was examined in 885 patients who received orthotopic liver transplantations for various end‐stage liver diseases between 1989 and 1990. The thrombosis was classified into four grades. Grade 1 was thrombosis of intrahepatic portal vein branches, grade 2 was thrombosis of the right or left portal branch or at the bifurcation, grade 3 was partial obstruction of the portal vein trunk, and grade 4 was complete obstruction of the portal vein trunk. Among the 849 patients without previous portosystemic shunt, 14 patients (1.6%) had grade 1, 27 patients (3.2%) had grade 2, 27 patients (3.2%) had grade 3 and 49 patients (5.8%) had grade 4 portal vein thrombosis. The incidence of portal vein thrombosis was highest (34.8%) in the patients with hepatic malignancy in the cirrhotic liver, followed by those with Budd‐Chiari syndrome (22.2%) and postnecrotic cirrhosis of various causes (15.7%). The patients with encephalopathy, ascites, variceal bleeding, previous splenectomy and small liver had significantly higher incidences of portal vein thrombosis than the others. The total incidence of portal vein thrombosis among the 36 patients with previous portosystemic shunt was 38.9%, which was significantly higher than that (13.8%) of those without shunt. (HEPATOLOGY 1992;16;1195–1198.)

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“…Because the re-bleeding rate in cirrhotics with PVT is high [12,14,25], a surgical portosystemic shunt could be proven as a second step, but results were contrasting. In fact, mortality at 6 months after surgery was 56% in the presence of PVT compared to 38% of cirrhotics without PVT, and mostly due to re-bleeding [12], but in a more recent study with a follow-up of 15 years, portocaval shunt with thrombectomy to restore portal flow yielded comparable outcome in patients with and without PVT [17].…”

Section: Managementmentioning

confidence: 99%

Portal vein thrombosis in liver cirrhosis

2008

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Portal vein thrombosis (PVT) is observed in 10-20% of patients with liver cirrhosis, which is responsible for 20% of all PVT cases. The main pathogenic factor of PVT in cirrhosis is the obstacle to portal flow, but acquired and inherited clotting abnormalities may play a role. The formation of collateral veins allows many patients to remain asymptomatic and prevents the onset of clinical complications also in patients with totally occlusive PVT. Gastrointestinal bleeding, thrombosis of superior mesenteric vein and refractory ascites are typical manifestations of PVT. Instrumental diagnosis can be obtained by colour-doppler ultrasonography. Future studies should verify whether asymptomatic PVT worsens liver failure, or if its life-threatening complications reduce survival in patients with cirrhosis. Moreover, randomized controlled trials should clarify the potential effectiveness of anticoagulant therapy in the treatment of PVT.

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Portal Vein Thrombosis Associated With Cirrhosis

Cited by 55 publications

References 11 publications

The incidence of portal vein thrombosis at liver transplantation

The incidence of portal vein thrombosis at liver transplantation

The Incidence of Portal Vein Thrombosis At Liver Transplantation

Portal vein thrombosis in liver cirrhosis

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