Portal vein thrombosis in the neonate: Risk factors, course, and outcome

Morag, Iris; Epelman, Mónica; Daneman, Alan; Moineddin, Rahim; Parvez, Boriana; Shechter, Tal; Hellmann, Jonathan

doi:10.1016/j.jpeds.2006.01.051

Cited by 119 publications

(141 citation statements)

References 21 publications

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“…Complete or partial revascularization occurred in only 56% of these patients (Kim et al 2001). Another study investigating children with PVT found that 73% had a history of UVC placement (Morag et al 2006).…”

Section: Incidencementioning

confidence: 99%

“…Signs of impaired liver function, hepatomegaly and splenomegaly should raise the suspicion of PVT; however, only about 10% of children with PVT develop acute clinical symptoms (Morag et al 2006). Thrombosis of the inferior vena cava can present with signs resembling obstruction of the renal vein (hematuria, retroperitoneal mass); however, these will occur bilaterally when the inferior vena cava is affected.…”

Section: Venousmentioning

confidence: 99%

“…PHTN is diagnosed at a mean of 5.7 years after the acute event (Alvarez et al 1983). Children with portal obstruction have a history of UVC placement in the neonatal period in 70% of the cases (Morag et al 2006). It might be worthwhile to investigate children with UVC history for signs of PHTN if left lobe hepatic atrophy, splenomegaly, thrombocytopenia or gastrointestinal hemorrhage is noticed.…”

Section: Re-assessmentmentioning

confidence: 99%

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Thrombosis in the critically ill neonate: incidence, diagnosis, and management

Nold¹

2008

VHRM

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Among children, newborn infants are most vulnerable to development of thrombosis and serious thromboembolic complications. Amongst newborns, those neonates who are critically ill, both term and preterm, are at greatest risk for developing symptomatic thromboembolic disease. The most important risk factors are infl ammation, DIC, impaired liver function, fl uctuations in cardiac output, and congenital heart disease, as well as exogenous risk factors such as central venous or arterial catheters. In most clinically symptomatic infants, diagnosis is made by ultrasound, venography, or CT or MRI angiograms. However, clinically asymptomatic vessel thrombosis is sometimes picked up by screening investigations or during routine imaging for other indications. Acute management of thrombosis and thromboembolism comprises a variety of approaches, including simple observation, treatment with unfractionated or low molecular weight heparin, as well as more aggressive interventions such as thrombolytic therapy or catheter-directed revascularization. Long-term follow-up is dependent on the underlying diagnosis. In the majority of infants, stabilization of the patients' general condition and hemodynamics, which allows removal of indwelling catheters, renders long-term anticoagulation superfl uous. Nevertheless, in certain types of congenital heart disease or inherited thrombophilia, long-term prophylaxis may be warranted. This review article focuses on pathophysiology, diagnosis, and acute and long-term management of thrombosis in critically ill term and preterm neonates.

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Section: Incidencementioning

confidence: 99%

Section: Venousmentioning

confidence: 99%

Section: Re-assessmentmentioning

confidence: 99%

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Thrombosis in the critically ill neonate: incidence, diagnosis, and management

Nold¹

2008

VHRM

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“…Hepatic injures are more severe than other complications with a high risk for morbidity and mortality (8). Lim-Dunham et al (9) studied the characteristic sonographic findings of hepatic erosion by UVCs.…”

Section: Discussionmentioning

confidence: 99%

Liver Hematoma Presented as Midgut Volvulus Due To Medical Error: A Case Report

et al. 2016

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Introduction: The use of an umbilical catheterization is a usual practice in neonatal units. The insertion of the catheter has potential complications. Case Presentation: Here, we report on our observation of a seven-day-old female newborn admitted for an abdominal distention and vomiting bile. Initially, diagnosis was midgut volvulus, for which an operation was performed. During the surgery, no intestinal malrotation, mesenteric defect or atresia was observed. Postoperative diagnosis was abdominal wall hematoma and rand ligament and ileus, as well as, sub-capsular liver hematoma. The patient had been hospitalized at birth at a neonatal intensive care unit (NICU). With the appearance of icterus on the first day of life, at the NICU tried to insert the umbilical catheter that had been filed. Conclusions:The complication found in the patient was the result of an aggressive act (the umbilical catheter insertion). This intervention should not be carried out unless there are clear indications, and if so, it should be done with much care.

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“…1,2 Entre los riesgos identificados como consecuencia de este procedimiento se encuentra la infección local, sepsis e isquemia regional, pero también se conoce la predisposición que hay para que el niño presente enterocolitis necrosante, episodios tromboembólicos, derrame pericárdico, arritmias cardiacas, ascitis y necrosis hepática. 3 Un riesgo menos común, pero no menos grave, es que como consecuencia de la infusión de soluciones y sustancias irritantes haya infección e inflamación del endotelio, lo que condiciona el desprendimiento de émbolos sépticos que se detienen en los sinusoides de la circulación local y dan lugar a la supuración hepática.…”

Section: Introductionunclassified

Onfalopileflebitis y absceso hepático neonatal

Baeza-Herrera¹,

López-Medina²,

Nájera-Garduño³

et al. 2015

Acta Pediatr Mex

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www.actapediatrica.org.mx caso clínico dE intErés EspEcial Acta Pediatr Mex 2015;36:177-181. Onfalopileflebitis y absceso hepático neonatalOmphalopylephlebitis and neonatal hepatic abscess RESUMENLa onfalopileflebitis y el absceso hepático en neonatos son raros y se asocian, en la mayoría de las ocasiones, con infecciones por Staphylococcus epidermidis y como complicación de la cateterización venosa umbilical. La manifestación única es una infección sistémica e implica dificultades diagnósticas. Presentamos los hallazgos clínicos y quirúr-gicos de un recién nacido masculino de 12 días con onfalopileflebitis y absceso hepático asociados con cateterización de la vena umbilical. ABSTRACTOmphalopylephlebitis and hepatic abscess in neonates are rare conditions mostly associated with Staphylococcus epidermidis infection and constitutes a complication of umbilical venous catheterization. The systemic infection is associated to diagnostic difficulties. We present the clinical and surgical findings of a twelve days male newborn patient with omphalopylephlebitis and hepatic abscess associated to umbilical vein catheterization.

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Portal vein thrombosis in the neonate: Risk factors, course, and outcome

Cited by 119 publications

References 21 publications

Thrombosis in the critically ill neonate: incidence, diagnosis, and management

Thrombosis in the critically ill neonate: incidence, diagnosis, and management

Liver Hematoma Presented as Midgut Volvulus Due To Medical Error: A Case Report

Onfalopileflebitis y absceso hepático neonatal

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