Portland cement enriched with hydroxyapatite for endodontic applications

Avram, Alexandra; Gorea, Maria; Balint, Reka; Timis, Lucia; Jitaru, Stefan; Mocanu, Aurora; Tomoaia-Cotişel, Maria

doi:10.24193/subbchem.2017.4.07

Cited by 10 publications

(10 citation statements)

References 27 publications

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“…A release of ions into water can be observed (Figure 3), for substituted hydroxyapatites, the amount of Ca released is higher than from pure HAP and very similar for all complex hydroxyapatites [71][72][73][74][75][76][77][78][79][80][81]. Multisubstituted hydroxyapatites with a long release of ions could be used as resorbable fillers for bone defects or even as coatings, as these particles could release ions for a longer period of time which can be beneficial for the formation of new bones.…”

Section: Ions Release From Hydroxyapatitementioning

confidence: 99%

Biomimetic and Antibacterial Composite for Orthopedic Implants

Balint¹,

Paltinean²,

FLOREA³

et al. 2022

AnnalsARSciBio

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The present paper shows how the development of synthetic nanostructured biomaterials, such as multisubstituted hydroxyapatite (msHAP) with Mg2+, Zn2+ and Sr2+ ions is important and beneficial at the same time for the normal functioning of the body. Moreover, the paper discusses a broad topic of major importance in orthopedic and dental surgery, namely the incorporation of msHAP into the polymeric matrix of poly lactic acid (PLA). This composite is used in order to cover the surface of the titanium implant in order to obtain bone integration and heal bone fractures. The review also highlights the importance of improving silver nanoparticle (SNPs) coating in order to combat postoperative infections. Through such approaches, medicine has managed to evolve considerably, and the contributions brought by great personalities and young researchers in the field have increased its area of applicability.

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Section: Ions Release From Hydroxyapatitementioning

confidence: 99%

Biomimetic and Antibacterial Composite for Orthopedic Implants

Balint¹,

Paltinean²,

FLOREA³

et al. 2022

AnnalsARSciBio

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“…Strontium can replace calcium in hydroxyapatite in any proportion, even up to 100%. Silicon plays an important role in biological performance by improving bioactivity, stimulates the proliferation and development of osteoblasts and mesenchymal stem cells [172][173][174][175][176][177].…”

Section: Calcium-based Phosphates (Hydroxyapatite Hap and β-Tricalciu...mentioning

confidence: 99%

Biomaterials With Enhanced Biological Functions for Medical Applications

Balint¹,

Paltinean²,

Tomoaia³

et al. 2021

AnnalsARSciBio

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Biomaterials and their use as implant coatings have been evaluated focusing on biocompatibility, biodegradability and constructive responses in terms of osseointegration, cell proliferation and cell adhesion. Biomaterials from natural (protein and polysaccharide) and synthetic (metallic, polymeric, ceramic and composite) sources have been identified. The role of biomaterials and implant coatings in the body through in vivo and in vitro experiments has been highlighted. In addition, methods for activating the surface of implants such as mechanical, chemical and physical ones are presented, as well as the classification of the deposition procedures but also of the interactions with the living system. This review addresses a topic with future challenges and perspectives in the biomedical field with the well-defined goal of maintaining and enhancing tissue elasticity, facilitating the healing of diseases suffered by patients and developing innovative materials capable of replacing or regenerating affected tissues.

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“…Hydroxyapatite (HAP) is the most stable form of calcium phosphate found as an inorganic component in bones and teeth [18][19][20][21]. Rapid progress in science is due to its characteristics of biocompatibility, bioactivity, bioaffinity, osteoconductivity and osseointegration, which make it applicable in the biomedical field such as orthopedic and dental surgery.…”

Section: Advanced Nanomaterialsmentioning

confidence: 99%

Advanced Nanomaterials and Coated Surfaces for Orthopedic Implants – A Review

Balint¹,

Mocanu²,

Tomoaia³

et al. 2021

AnnalsARSciPhysChem

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Critical-sized defects in bone induced by trauma have in numerous presented cases difficult challenges to the current treatment for bone repair. The main purpose of bone tissue engineered scaffolds is to use advanced materials to promote the natural healing process of bone which does not easily occur in critical-sized defects or on metallic implants. A synthetic bone scaffold and a coating on Ti implants must be biocompatible and biodegradable to allow the native tissue integration, and mimic the chemical composition and structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold and the coating layers on metallic implants must be capable of releasing essential physiologic elements, like Mg, Zn, Sr and Si, and also containing bioactive molecules (e.g., collagen, COL) to accelerate extracellular matrix production and tissue integration. Also, these advanced materials might be doped with drugs (e.g., antibiotics, such as vancomycin) to prevent undesired biological response such as infections, especially with Staphylococcus aureus, S. aureus. Various biomaterials include hydroxyapatite (HAP) ceramics or multifunctional hydroxyapatite substituted with Mg, Zn, Sr and Si, mf-HAP, polymers, such as poly lactic acid (PLA, approved for medical applications by Food and Drug Administration, US FDA, and collagen, or their mixtures as biomimetic composites which have been investigated for their potential as bone scaffold materials and coatings on metallic implants. This article briefly reviews the physical and chemical characteristics of used advanced materials and describes the key-technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an over view of local drug delivery as it pertains to bone tissue engineering.

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Portland cement enriched with hydroxyapatite for endodontic applications

Cited by 10 publications

References 27 publications

Biomimetic and Antibacterial Composite for Orthopedic Implants

Biomimetic and Antibacterial Composite for Orthopedic Implants

Biomaterials With Enhanced Biological Functions for Medical Applications

Advanced Nanomaterials and Coated Surfaces for Orthopedic Implants – A Review

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