Portosplenomesenteric Venous Thrombosis in Patients With Acute Pancreatitis Is Associated With Pancreatic Necrosis and Usually Has a Benign Course

Role of Thrombophilia in Splanchnic Venous Thrombosis in Acute Pancreatitis

“…The superior mesenteric vein was the least common vessel to be involved, with thrombosis observed in only 4 (15.3%) patients. This pattern of vascular involvement is consistent with previous studies [8,9]. Almost all the previous studies reported the splenic vein to be the most commonly involved vessel.…”

“…The reported incidence of SVT in previous studies ranged from 1.8-36.5% [6][7][8][9][17][18][19]. In our cohort of 96 patients, SVT was found in 26 (27.1%) patients.…”

“…Moreover, there is a paucity of literature on the natural history of SVT in AP, with the majority of studies reporting that complications directly related to SVT are infrequent and that most of the patients remain asymptomatic with regard to splanchnic vein thrombosis [8,9]. In addition, spontaneous recanalization of a thrombosed splanchnic venous system has been reported in up to 30% of patients [15].…”

“…There is wide variation in the incidence of SVT in AP between different studies, with reported frequencies ranging from as low as 1.8% to as high as 36.5% [6][7][8][9]. Several studies have looked at the pathophysiological mechanisms associated with SVT [8][9][10]. Factors that have been implicated are pancreatic and peripancreatic edema, inflammatory cellular infiltration, direct injury to blood vessels and fluid collection compressing the vessels and causing stasis of blood flow.…”

“…Factors that have been implicated are pancreatic and peripancreatic edema, inflammatory cellular infiltration, direct injury to blood vessels and fluid collection compressing the vessels and causing stasis of blood flow. Peri-pancreatic inflammatory changes or fluid collecstions create a milieu that promotes the development of SVT [9,11].…”