Portulene, a new diterpene fromPortulaca oleraceaL.

Elkhayat, Ehab S.; Ibrahim, Sabrin R. M.; Aziz, Mohamed Abdel

doi:10.1080/10286020802320590

Cited by 90 publications

(61 citation statements)

References 21 publications

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“…Recent research revealed a wide range of biological activities such as antifungal effect against dermatophytes of the genera Trichophyton, antinociceptive, antioxidant, and wound-healing activity. A bronchodilatory effect in asthmatic patients, skeletal muscle relaxant, and antifertility effect were also reported for P. oleracea (Elkhayat et al, 2008). Until now, however, there were no pharmacological studies upon the anxiolytic-like effects of P. oleracea.…”

Section: Introductionmentioning

confidence: 98%

Anxiolytic-like effects of Portulaca oleraceae L. using the elevated plus-maze in mice

Lee¹,

Yoon²,

Ryu³

et al. 2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe purpose of this study was to characterize the putative anxiolytic-like effects of the 70% ethanol extract of Portulaca oleracea (EPO) using an elevated plus maze (EPM) in mice. The EPO was orally administered at 50, 100, 200 or 400 mg/kg to ICR mice, 1 h before the behavioral evaluation in the EPM, respectively. Control mice were treated with an equal volume of 10% tween 80, and positive control mice with diazepam (1 mg/kg). Single treatments of the EPO significantly increased the percentage of time spent and arm entries into the open arms of the EPM versus controls (P < 0.05). Moreover, there were no changes in the locomotor activity and myorelaxant effects in any group compared with the saline controls. In addition, the anxiolyticlike effects of the EPO were blocked by flumazenil (10 mg/kg, i.p), a GABA receptor antagonist. These results indicate that P. oleracea is an effective anxiolytic agent, and suggest that the anxiolytic-like effects of P. oleracea is mediated via the GABAergic nervous system.

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Section: Introductionmentioning

confidence: 98%

Anxiolytic-like effects of Portulaca oleraceae L. using the elevated plus-maze in mice

Lee¹,

Yoon²,

Ryu³

et al. 2009

Oriental Pharmacy and Experimental Medicine

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“…A bronchodilatory effect in asthmatic patients, skeletal muscle relaxant and antifertility effect were also reported for P.O. (Elkhayat et al, 2008). It has been described as a "power food" of future because of its high nutritive and antioxidant properties (Simopoulos et al, 1995).…”

Section: Introductionmentioning

confidence: 98%

“…The hepatoprotective activities of hydroalcoholic extract of stems and leaves of P.O. in rats treated with CCl 4 (Elkhayat et al, 2008) or rifampicin (Kulkarni et al, 2007) were previously reported. The present study was designed to evaluate the protective effects of Portulaca oleracea against Paracetamol-induced hepatic toxicity in male rats.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in vivo Antioxidant and Hepatoprotective Activity of Portulaca oleracea L. against Paracetamol-Induced Liver Toxicity in Male Rats

Ahmida¹

2010

American Journal of Pharmacology and Toxicology

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Problem statement: Oxidative stress plays a major role in paracetamol induced hepatotoxicity. Portulaca oleracea (P.O.) has been shown to exhibit antioxidant properties. The present study aimed to investigate the effect of P.O. on the oxidative stress in Paracetamol-induced hepatic toxicity in male rats. Approach: Forty male rats were divided into four groups. Group I served as control; Group II Received isotonic saline for 20 days and then simultaneously administered with paracetamol 750 mg kg −1 body wt. every 72 h for 10 days; Group III received freshly prepared P.O. for 30 days; Group IV received freshly prepared P.O. for 20 days and then simultaneously administered with paracetamol 750 mg kg −1 body wt. every 72 h for 10 days. All animals were sacrificed cervical decapitation 24 h after the last application and the blood was collected for the determination of serum marker of lipid peroxidation, antioxidant and histology of the liver was performed. Results: Paracetamol treatment resulted in an increase in the hepatic TBARS content and depletion in total antioxidant capacity, reduced glutathione content, catalase and superoxide dismutase activities. Administration of P.O. with paracetamol significantly ameliorated the indices of hepatotoxicity induced by paracetamol. In addition, P.O. alleviated paracetamol induced oxidative changes in liver. Conclusion: The present study demonstrated that P.O. inhibits paracetamol-induced hepatotoxicity and might serve as a protective agent with paracetamol to limit its free radical induced liver injury.

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“…In contrast, they were diminished in Po-treated group (−42%), most likely due to its antioxidant properties. Elkhayat et al [23] showed that treatment with alcoholic extract of Po restored the hepatic marker enzymes, which demonstrated hepatoprotective activity in hepatic injured rats.…”

Section: Plasma Albumin Uric Acid and Transaminases Activitiesmentioning

confidence: 99%

Portulaca oleracea Leaf Aqueous Lyophilized Extract Reduces Hyperglycemia and Improves Antioxidant Status of Red Blood Cells and Liver in Streptozotocin-Induced Diabetic Wistar Rats

Guenzet¹,

Krouf²,

Berzou³

2017

JPP

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Abstract:The aim of this study was to investigate the antihyperglycemic and antioxidant effects of Po (Portulaca oleracea) lyophilised aqueous extract in diabetic male Wistar rats. Diabetes was induced intraperitonially by a single injection of STZ (streptozotocin) (60 mg/kg bw (body weight)). Twenty diabetic rats, weighing 263 ± 5 g, were divided into two groups fed a casein diet supplemented or not with Po extract (1 g/kg bw), for four weeks. Control group (n = 6) received 0.23~0.25 mL of citrate buffer and was fed a standard diet during the experiment. The study was carried out at Oran University, Algeria and the entire experiments lasted from September 2011 to July 2012. Blood was obtained from the abdominal aorta of rats after fasting overnight and standard methods were used for the extraction of spices, determination of glycemia, insulinemia, lipid peroxidation and antioxidant enzymes activities. Portulaca oleracea treated compared to untreated rats, glycemia and HbA1c values were respectively 2.8-and 1.7-fold lower. TBARS (thiobarbituric acid reactive substances) concentrations were reduced in RBC (red blood cells) (−54%) and plasma (−65%). Moreover, in liver and kidney, TBARS values were respectively 1.8-and 2-fold lower. SOD (superoxide dismutase) and GSH-Px (glutathione peroxidase) activities were increased respectively by +38% and +85%, in liver. GSSG-Red (glutathione reductase) activity was 1.9-fold higher in kidney, while CAT (catalase) was improved in kidney (+48%). In RBCs, SOD, GSH-Px, GSSH-Red and CAT activities were increased by 31%, 42%, 56% and +50%, respectively. These data have cast a new light on the actions of Portulaca oleracea and its antioxidant potential benefits in preventing diabetes and its complications.

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Portulene, a new diterpene fromPortulaca oleraceaL.

Cited by 90 publications

References 21 publications

Anxiolytic-like effects of Portulaca oleraceae L. using the elevated plus-maze in mice

Anxiolytic-like effects of Portulaca oleraceae L. using the elevated plus-maze in mice

Evaluation of <i>in vivo</i> Antioxidant and Hepatoprotective Activity of <i>Portulaca oleracea</i> L. against Paracetamol-Induced Liver Toxicity in Male Rats

Portulaca oleracea Leaf Aqueous Lyophilized Extract Reduces Hyperglycemia and Improves Antioxidant Status of Red Blood Cells and Liver in Streptozotocin-Induced Diabetic Wistar Rats

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