Pos-010 the Heart-Kidney Cross Talk in Cardiac Intensive Care Unit

Abstract

Conclusions: Not only is this an unusual case of polyomavirus BK virus nephropathy in the native kidney with a strikingly high BK load of 10 8 , but it is also the first reported association of BK virus nephropathy with thrombotic microangiopathy in a patient with no prior transplantation history and no active immunosuppression regimen. This case highlights the importance of considering BK virus nephropathy in the differential diagnosis of kidney dysfunction not only among transplant recipient but in all immunocompromised hosts including B-cell depleting regimens. If left untreated, we believe that high BK viral loads can become clinically symptomatic and cause endothelial dysfunction resulting in renal TMA as we described here for the first time. More studies are needed to define the best therapeutic approach to BK virus nephropathy in non-transplant patients.