Pos-603 Catheter-Relatd Blood Stream Infection: Patterns and Predictors Among Patients With End-Stage Renal Disease Undergoing Haemodialysis in Abuja, North Central Nigeria

Bello, Fernando A

doi:10.1016/j.ekir.2022.01.636

Cited by 2 publications

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“…In our study, the culture positivity rate among those who had CRBSI was 32.7%. This culture positivity was similar to findings from another study by Bello et al reporting a culture positivity among patients with CRBSI of 33.3% [ 17 ] but higher than findings of culture positivity of 27.3% by Amira et al [ 16 ] .. However, a study by Farrington et al reported an culture positivity of 85% [ 19 ] which was higher than the findings in our study.…”

Section: Discussionsupporting

confidence: 90%

“…High incidence and prevalence of CRBSI have also been reported in countries in Africa and for West Africa, in Nigeria [ 15 , 16 ]. A laboratory surveillance study in Pretoria, South Africa reported the incidence rate of 10.1 episodes per 1000 catheter days, 3.7 episodes per 1000 admissions and 0.57 per 1000 in-patient days [ 15 ].A recent study in Nigeria demonstrated a CRBSI prevalence of 33.3% in patients undergoing haemodialysis [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Catheter-Related Bloodstream Infections among patients on maintenance haemodialysis: a cross-sectional study at a tertiary hospital in Ghana

Opoku-Asare,

Boima,

Ganu

et al. 2023

BMC Infect Dis

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Background Catheter-Related Bloodstream Infections (CRBSIs) are notable complications among patients receiving maintenance haemodialysis. However, data on the prevalence of CRBSIs is lacking. This study was conducted to determine the prevalence and factors associated with CRBSIs among patients receiving haemodialysis in the renal unit of the largest tertiary hospital in Ghana. Methods A hospital-based cross-sectional study was conducted on patients receiving maintenance haemodialysis via central venous catheters (CVC) between September 2021 and April 2022. Multivariate analysis using logistic regression was used to determine the risk factors that were predictive of CRBSI. Analysis was performed using SPSS version 23 and a p-value<0.05 was statistically significant. Results The prevalence of CRBSI was 34.2% (52/152). Of these, more than half of them (53.9%(28/52)) had Possible CRBSI while 11.5% (6/52) had Definite CRBSI. Among the positive cultures, 62% (21/34) were from catheter sites whilst the rest were from peripheral blood. Gram-negative cultures made up 53% (18/34) of positive cultures with the rest being Gram positive cultures. Acinetobacter baumannii (33.3% (6/18)) was the commonest organism isolated among Gram-negative cultures whilst Coagulase negative Staphylococci (43.7% (7/16)) was the commonest organism isolated among Gram-positve cultures. Gram-negative bacilli were more predominant in this study making up 52.9% of the total bacteria cultured. Sex, duration of maintenance dialysis, underlying cause of End-stage kidney disease, mean corpuscular haemoglobin (MCH), neutrophil count and lymphocyte count were significantly predictive of CRBSI status (p<0.05). Conclusion There was a high prevalence of CRBSI among patients undergoing haemodialysis. The commonest causative agent was Coagulase negative Staphylococci, however there was a predominance of Gram-negative bacilli as compared to Gram positive cocci. There is a need to set up infection surveillance unit in the renal unit to track CRBSI and put in place measures to reduce these CRBSI.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Catheter-Related Bloodstream Infections among patients on maintenance haemodialysis: a cross-sectional study at a tertiary hospital in Ghana

Opoku-Asare,

Boima,

Ganu

et al. 2023

BMC Infect Dis

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Adverse Outcomes After Tunneled Dialysis Catheter–Related Bloodstream Infections—Too Dark at the End of This Tunnel?

Pandit,

Rao,

Ansari

et al. 2024

Seminars in Dialysis

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BackgroundTunneled dialysis catheters (TDCs) are preferred over temporary noncuffed catheters for access in patients on maintenance hemodialysis. The removal of TDC after catheter‐related blood stream infections (CRBSIs) is often not practiced even when indicated, and the adverse outcomes after such salvage are presently unclear.Aims and ObjectivesThe study aimed to evaluate adverse outcomes after the first episode of definite or probable CRBSI. The composite adverse outcome was recorded as the presence of at least one of three adverse outcomes—death in the index hospital admission, occurrence of recurrent bacteremia, and death within 3 months.ResultsDuring the study period, the TDC CRBSI incidence rate was 6.9/1000 catheter days. Of the 110 study participants, majority were male (63%), with a median age of 35 years, belonging to rural (56%) and agrarian (39%) communities, and 66% were getting dialyzed at stand‐alone dialysis units. Gram‐negative infections predominated (64%), with 37% of isolates showing resistance to carbapenems. Catheter salvage was practiced in 80%, and immediate catheter removal was done only in the sickest of patients (in seven of eight with in‐hospital mortality). Predictors of composite adverse outcomes included sites other than right internal jugular vein (OR 3.6) and resistance to β lactam‐β lactamase inhibitors (OR 16.2). At a median follow‐up of 7 months, all survivors at 3 months were alive and 46% had recurrent TDC CRBSIs.ConclusionUp to one‐half of patients with end‐stage kidney disease experienced composite adverse outcomes after the first episode of TDC CRBSI, with infection‐related 3‐month mortality of 15%.Trial RegistrationClinical trial number: CTRI/2023/10/058556

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Pos-603 Catheter-Relatd Blood Stream Infection: Patterns and Predictors Among Patients With End-Stage Renal Disease Undergoing Haemodialysis in Abuja, North Central Nigeria

Cited by 2 publications

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Catheter-Related Bloodstream Infections among patients on maintenance haemodialysis: a cross-sectional study at a tertiary hospital in Ghana

Catheter-Related Bloodstream Infections among patients on maintenance haemodialysis: a cross-sectional study at a tertiary hospital in Ghana

Adverse Outcomes After Tunneled Dialysis Catheter–Related Bloodstream Infections—Too Dark at the End of This Tunnel?

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