Pos1552 no Burn-Out in Pediatric-Onset Behçet’s Disease Patients During Adulthood Follow-Up

Abstract

BackgroundAlthough onset of Behçet’s Disease (BD) is common in the second or third decade, initial symptoms occur under the age of 16 years in 4–26% of the patients [1].ObjectivesIn this study we aimed to assess the clinical course of pediatric onset BD in adulthood period.MethodsThe files of 1114 BD patients were reviewed retrospectively. 51 (4.6%) (F/M:21/30) pediatric-onset BD patients were included in the analysis. Demographic and clinical characteristics, follow-up and treatment data of the patients were recorded from files.ResultsThe median age at diagnosis was 16 (14-17) years, and the median follow-up duration was 51 (26-96) months. Of all patients, 33.3% (n=17) had ocular involvement, 27.5% (n=14) had vascular involvement, 17.6% (n=9) had central nervous system involvement, and 3.9% (n=2) had gastrointestinal system involvement. Erythema nodosum was more common in females (p=0.008) and vascular involvement was more common in males (p=0.025).At the end of follow-up, 32 (62.8%) patients had major organ involvement, half of them had at the time of diagnosis.Forty-seven (M:27/F:20) patients had a follow-up with median of 50 (20-82) months in adulthood period. Thirty-one (65.6%) patients had major organ involvement. While 20 (64.5%) patients had major organ involvement in the pediatric period, 11 (35.5%) patients developed major organ involvement in adulthood. Overall, 19 (40.4%) patients had active disease manifestations (relapse and/or new major organ involvement) in adulthood follow-up. Of these patients, 11 (57.9%) had new major organ involvement, 7 (36.8%) had a relapse of the same organ, and one (5.3%) had both new major organ involvement and a relapse. The disease course of patients is seen in Table 1.ConclusionOur results show that, about half of the pediatric-onset BD patients still have active disease manifestations (mainly new major organ involvement) in adulthood period.Table 1.Disease course of patients followed in adulthood period.Patients followed in adulthoodn=47 (%)Major organ involvement in childhood20 (42.6%)Relapse or/and new major organ involvementNo relapse or major organ involvement8 (17%)12 (25.5%)Mucocutaneous disease in childhood27 (57.4%)New major organ involvementNo major organ involvement11 (23.4%)16 (34%)Reference[1]Yildiz, M., et al., Pediatric Behçet’s disease-clinical aspects and current concepts. European journal of rheumatology, 2020.7(Suppl 1): p. S38.Acknowledgements:NIL.Disclosure of InterestsNone Declared.