Posaconazole and isavuconazole induced hypomagnesaemia

Burston, J.; Robertson, Mark P.; Hal, Sebastian Van; Pinto, Angie N

doi:10.1016/j.mmcr.2018.09.007

Cited by 5 publications

(3 citation statements)

References 12 publications

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“… 36 , 37 , 42 , 43 With regard to other antifungal agents, posaconazole and isavuconazole have also been associated with hypomagnesemia. 44 The exact mechanism has not been elucidated.…”

Section: Drugs Associated With Hypomagnesemiamentioning

confidence: 99%

“…Furthermore, both classes of drugs can also cause other renal tubular disorders, including proximal and distal renal tubular acidosis and nephrogenic diabetes insipidus 36,37,42,43 . With regard to other antifungal agents, posaconazole and isavuconazole have also been associated with hypomagnesemia 44 . The exact mechanism has not been elucidated.…”

Section: Drugs Associated With Hypomagnesemiamentioning

confidence: 99%

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An overview of diagnosis and management of drug‐induced hypomagnesemia

Liamis

Hoorn

Florentin

et al. 2021

Pharmacology Res & Perspec

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Hypomagnesemia is usually defined as a serum magnesium (Mg) level below 0.65 mmol/L (1.3 mEq/L; 1.5 mg/dl). 1 Serum Mg exists in three forms: (1) free or ionized Mg, the physiologically active form that accounts for 55%-70% of total serum Mg; (2) Mg complexed to anions, including bicarbonates, sulfates, phosphates, and citrates (5%-15%) and (3) Mg bound to serum proteins (primarily albumin), constituting the remaining approximately 30%. 2 Similarly to hypocalcemia, hypoalbuminemia is also related to spurious hypomagnesemia. 3 Consequently, in hypoalbuminemic states (serum albumin <4 g/dl) corrected serum Mg should be calculated using the formula: corrected Mg (mmol/L) = measured Mg(mmol/L) + 0.005 × (40 − albumin g/L). 4 Correction of Mg for albumin levels is rarely performed in clinical practice, a strategy that should probably change.The incidence of hypomagnesemia varies considerably from merely 2% among individuals in the community up to as high as 65% in patients hospitalized in intensive care units. 5,6 Discrepancies in the reported incidences of hypomagnesemia are attributed to the fact that serum Mg is not routinely measured and that this ion is

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“… 36 , 37 , 42 , 43 With regard to other antifungal agents, posaconazole and isavuconazole have also been associated with hypomagnesemia. 44 The exact mechanism has not been elucidated.…”

Section: Drugs Associated With Hypomagnesemiamentioning

confidence: 99%

Section: Drugs Associated With Hypomagnesemiamentioning

confidence: 99%

An overview of diagnosis and management of drug‐induced hypomagnesemia

Liamis

Hoorn

Florentin

et al. 2021

Pharmacology Res & Perspec

View full text Add to dashboard Cite

show abstract

“…After exclusion of reports published in non-English language or in which clinical and therapeutic data were not available for the purpose of the present review, a total of 41 cases have been included. Clinical and demographic characteristics, details of the antifungal treatment, outcome and adverse effects reported on these patients are summarized in Table 2 [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ]. Thirty-three out of 42 (78.5%) patients were male and the mean age was 52 years (range 20–79).…”

Section: Isavuconazole In Non-hematological Patientsmentioning

confidence: 99%