Position sensitivity in phasically discharging nucleus accumbens neurons of rats alternating between tasks requiring complementary types of spatial cues

Shibata, Ryoko; Mulder, A. H.; Trullier, Olivier; Wiener, Sidney I.

doi:10.1016/s0306-4522(01)00400-6

Cited by 52 publications

(50 citation statements)

References 61 publications

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“…The number of well isolated, stable, and sufficiently active single units recorded per session ranged from 14 to 19 (mean Ϯ SEM: 16.3 Ϯ 0.35). The precise nature of the behavioral correlates of VS firing patterns in the T-maze task falls outside the scope of this study but generally agrees with previous reports on rats and monkeys (Schultz et al, 1992;Lavoie and Mizumori, 1994;Shibata et al, 2001;Setlow et al, 2003). Briefly, behavioral correlates were analyzed using rate maps (plotting the firing rate of a single unit as a function of two-dimensional maze position) (Fig.…”

Section: Resultssupporting

confidence: 68%

“…Briefly, this profile consisted of the penetration of neocortical layer V, with intense unit activity of high amplitude, of the corpus callosum, marked by an overall quiescence, followed by a number of encounters with dorsal and ventral striatal units as described by Callaway and Henriksen (1992), Lavoie and Mizumori (1994), and Shibata et al (2001) (see also below). At the end of an experiment the final positions of the tetrodes in the VS were marked by passing a 10 sec, 25 A current through one lead of each tetrode.…”

Section: Histologymentioning

confidence: 99%

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The Ventral Striatum in Off-Line Processing: Ensemble Reactivation during Sleep and Modulation by Hippocampal Ripples

et al. 2004

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Previously it has been shown that the hippocampus and neocortex can spontaneously reactivate ensemble activity patterns during post-behavioral sleep and rest periods. Here we examined whether such reactivation also occurs in a subcortical structure, the ventral striatum, which receives a direct input from the hippocampal formation and has been implicated in guidance of consummatory and conditioned behaviors. During a reward-searching task on a T-maze, flanked by sleep and rest periods, parallel recordings were made from ventral striatal ensembles while EEG signals were derived from the hippocampus. Statistical measures indicated a significant amount of reactivation in the ventral striatum. In line with hippocampal data, reactivation was especially prominent during postbehavioral slow-wave sleep, but unlike the hippocampus, no decay in pattern recurrence was visible in the ventral striatum across the first 40 min of post-behavioral rest. We next studied the relationship between ensemble firing patterns in ventral striatum and hippocampal ripples-sharp waves, which have been implicated in pattern replay. Firing rates were significantly modulated in close temporal association with hippocampal ripples in 25% of the units, showing a marked transient enhancement in the average response profile. Strikingly, ripple-modulated neurons in ventral striatum showed a clear reactivation, whereas nonmodulated cells did not. These data suggest, first, the occurrence of pattern replay in a subcortical structure implied in the processing and prediction of reward and, second, a functional linkage between ventral striatal reactivation and a specific type of high-frequency population activity associated with hippocampal replay.

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Section: Resultssupporting

confidence: 68%

Section: Histologymentioning

confidence: 99%

The Ventral Striatum in Off-Line Processing: Ensemble Reactivation during Sleep and Modulation by Hippocampal Ripples

et al. 2004

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“…Three units responded to one reward site only and, in addition, did not fire differentially for reward presence versus absence. Although these cells were included in our analysis as reward related, it cannot be excluded that their firing is purely spatially modulated (Lavoie and Mizumori, 1994;Shibata et al, 2001). However, exclusion of these units from analysis yielded similar results.…”

Section: Behavioral Correlates Of Ventral Striatal Firing Patternsmentioning

confidence: 93%

Preferential Reactivation of Motivationally Relevant Information in the Ventral Striatum

Lansink

Goltstein²,

Lankelma³

et al. 2008

Journal of Neuroscience

157

160

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Spontaneous "off-line" reactivation of neuronal activity patterns may contribute to the consolidation of memory traces. The ventral striatum exhibits reactivation and has been implicated in the processing of motivational information. It is unknown, however, whether reactivating neuronal ensembles specifically recapitulate information relating to rewards that were encountered during wakefulness. We demonstrate a prolonged reactivation in rat ventral striatum during quiet wakefulness and slow-wave but not rapid eye movement sleep. Reactivation of reward-related information processed in this structure was particularly prominent, and this was primarily attributable to spike trains temporally linked to reward sites. It was accounted for by small, strongly correlated subgroups in recorded cell assemblies and can thus be characterized as a sparse phenomenon. Our results indicate that reactivated memory traces may not only comprise feature-and context-specific information but also contain a value component.

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“…In fact, some studies have reported "spatial" firing of striatal neurons (e.g., Schmitzer-Torbert and Redish 2008; Shibata et al 2001) and have even suggested that striatal neurons show allocentric coding very similar to that of hippocampal neurons ). This has been put forward as evidence against the hypothesis that striatum and hippocampus are components of distinct memory systems .…”

Section: Introductionmentioning

confidence: 99%

Striatal Versus Hippocampal Representations During Win-Stay Maze Performance

Berke

Breck

Eichenbaum

2009

Journal of Neurophysiology

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Berke JD, Breck JT, Eichenbaum H. Striatal versus hippocampal representations during win-stay maze performance. J Neurophysiol 101: 1575-1587, 2009. First published January 14, 2009 doi:10.1152/jn.91106.2008. The striatum and hippocampus are widely held to be components of distinct memory systems that can guide competing behavioral strategies. However, some electrophysiological studies have suggested that neurons in both structures encode spatial information and may therefore make similar contributions to behavior. In rats well trained to perform a win-stay radial maze task, we recorded simultaneously from dorsal hippocampus and from multiple striatal subregions, including both lateral areas implicated in motor responses to cues and medial areas that work cooperatively with hippocampus in cognitive operations. In each brain region, movement through the maze was accompanied by the continuous sequential activation of sets of projection neurons. Hippocampal neurons overwhelmingly were active at a single spatial location (place cells). Striatal projection neurons were active at discrete points within the progression of every trial-especially during choices or following reward delivery-regardless of spatial position. Place-cell-type firing was not observed even for medial striatal cells entrained to the hippocampal theta rhythm. We also examined neural coding in earlier training sessions, when rats made use of spatial working memory to guide choices, and again found that striatal cells did not show placecell-type firing. Prospective or retrospective encoding of trajectory was not observed in either hippocampus or striatum, at either training stage. Our results indicate that, at least in this task, dorsal hippocampus uses a spatial foundation for information processing that is not substantially modulated by spatial working memory demands. By contrast, striatal cells do not use such a spatial foundation, even in medial subregions that cooperate with hippocampus in the selection of spatial strategies. The progressive dominance of a striatum-dependent strategy does not appear to be accompanied by large changes in striatal or hippocampal single-cell representations, suggesting that the conflict between strategies may be resolved elsewhere.

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Position sensitivity in phasically discharging nucleus accumbens neurons of rats alternating between tasks requiring complementary types of spatial cues

Cited by 52 publications

References 61 publications

The Ventral Striatum in Off-Line Processing: Ensemble Reactivation during Sleep and Modulation by Hippocampal Ripples

The Ventral Striatum in Off-Line Processing: Ensemble Reactivation during Sleep and Modulation by Hippocampal Ripples

Preferential Reactivation of Motivationally Relevant Information in the Ventral Striatum

Striatal Versus Hippocampal Representations During Win-Stay Maze Performance

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