Positional control of chiasma distribution in the house mouse. Chiasma distribution in mice homozygous and heterozygous for an inversion in chromosome 1

Gorlov, Ivan P.; Ladygina, T. Yu.; Serov, O. L.; Borodin, Pavel M.

doi:10.1038/hdy.1991.55

Cited by 13 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gorlov and Borodin (1995) [ 43 ], for instance, showed that a large inversion had no effect on the global recombination rate. In an earlier study, the same authors had observed a reduction of recombination due to a decrease in the number of chiasmata in the inverted region [ 44 ]. In men, Kirkpatrick et al .…”

Section: Discussionmentioning

confidence: 99%

Meiotic Recombination Analyses in Pigs Carrying Different Balanced Structural Chromosomal Rearrangements

et al. 2016

View full text Add to dashboard Cite

Correct pairing, synapsis and recombination between homologous chromosomes are essential for normal meiosis. All these events are strongly regulated, and our knowledge of the mechanisms involved in this regulation is increasing rapidly. Chromosomal rearrangements are known to disturb these processes. In the present paper, synapsis and recombination (number and distribution of MLH1 foci) were studied in three boars (Sus scrofa domestica) carrying different chromosomal rearrangements. One (T34he) was heterozygote for the t(3;4)(p1.3;q1.5) reciprocal translocation, one (T34ho) was homozygote for that translocation, while the third (T34Inv) was heterozygote for both the translocation and a pericentric inversion inv(4)(p1.4;q2.3). All three boars were normal for synapsis and sperm production. This particular situation allowed us to rigorously study the impact of rearrangements on recombination. Overall, the rearrangements induced only minor modifications of the number of MLH1 foci (per spermatocyte or per chromosome) and of the length of synaptonemal complexes for chromosomes 3 and 4. The distribution of MLH1 foci in T34he was comparable to that of the controls. Conversely, the distributions of MLH1 foci on chromosome 4 were strongly modified in boar T34Inv (lack of crossover in the heterosynaptic region of the quadrivalent, and crossover displaced to the chromosome extremities), and also in boar T34ho (two recombination peaks on the q-arms compared with one of higher magnitude in the controls). Analyses of boars T34he and T34Inv showed that the interference was propagated through the breakpoints. A different result was obtained for boar T34ho, in which the breakpoints (transition between SSC3 and SSC4 chromatin on the bivalents) seemed to alter the transmission of the interference signal. Our results suggest that the number of crossovers and crossover interference could be regulated by partially different mechanisms.

show abstract

Section: Discussionmentioning

confidence: 99%

Meiotic Recombination Analyses in Pigs Carrying Different Balanced Structural Chromosomal Rearrangements

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Проксимальный (прицентро мерный) рекомбинаци онный пик был характерен для плеч акроцентрических хромосом черной крачки и отсутствовал в тех же пле чах, которые входили в состав мета центрической хромосомы у речной крачки. Это подтверждает предпо ложение о том, что паттерн распре деления рекомбинационных обменов в большей степени опреде ляется морфологией хромосомы, а не гене тическим со держанием отдельных ее районов (Gorlov et al, 1991).…”

Section: генетика животных вавиловский журнал генетики и селекции • 2unclassified

Synapsis and recombination of autosomes and sex chromosomes in two terns (Sternidae, Charadriiformes, Aves)

Lisachov¹,

Malinovskaya²,

Druzyaka³

et al. 2017

Vestn. VOGiS

View full text Add to dashboard Cite

The frequency of recombination and the patterns of crossover site distribution along the chromosomes vary considerably among animal species, including closely related species. Several hypotheses concerning the adaptive value and evolution of these variations were proposed. It was supposed that the recombination patterns of the species' genomes are influenced by their phylogenetic history and ecology. However, most original data were obtained from mammals. The mammals show high karyological variability, which strongly influences the recombination patterns. Therefore it is important to study recombination rate and distribution in more karyologically stable taxa, such as reptiles and birds. We used immunolocalization of SYCP3, the protein of the lateral element of the synaptonemal complex (SC), centromere proteins and the mismatch-repair protein MLH1, which is associated with the recombination nodules, at the synaptonemal complex spreads of prophase oocytes of two tern species, black tern (Chlidonias niger) and common tern (Sterna hirundo). We first described the karyotype of Ch. niger (2n = 74, FN= 94) and identified suggestive rearrangements by which its karyotype differs from that of S. hirundo (2n = 68, FN = 90). We found that these species significantly differed by the numbers of the MLH1 foci per cell (Ch. niger: 53.0 ± 4.2; S. hirundo: 44.1 ± 5.0). We showed that the difference in the crossover numbers per cell was determined by the difference in the SC length (total and of individual bivalents) and by chromosomal rearrangements, which also influenced the distributions of crossover sites along the chromosomes. The difference in recombination patterns was higher between the rearranged homeologues than between the non-rearranged ones. We investigated the synaptic patterns of the heteromor-Интенсивность мейотической рекомбинации и закономерности распределения точек кроссинговера вдоль хромосом значительно варьируют между видами животных, в том числе близкородствен-ными. Предложено несколько гипотез об адаптивном значении этих различий и их эволюции. Высказаны предположения о том, что рекомбинационные характеристики видов обусловлены фило-генетической историей видов и их экологией. Однако большая часть исходных данных получена на млекопитающих, у которых характеристики рекомбинации находятся под влиянием значи-тельной кариологической изменчивости. В этой связи изучение характеристик рекомбинации у таксонов с более стабильными карио типами, таких как рептилии и птицы, представляется акту-альным. В данной работе использовали метод флуоресцентной иммунолокализации белка бокового элемента синаптонемного комплекса (SYCP3), белков центромеры и белка мисматч-репара-ции MLH1, маркирующего сайты кроссинговера, на препаратах распластанных профазных ооцитов для изучения особенностей синапсиса и рекомбинации у двух видов птиц -черной крачки (Chlidonias niger) и речной крачки (Sterna hirundo). Мы впервые охарактеризовали кариотип Ch. niger (2n = 74, FN = 94), уточнили описание кариотипа S. hirundo (2n = 68, FN = 90) и иденти...

show abstract

“…In ml 2/ + the frequency of the loops was much lower (36.8 per cent), and almost all of the loops were incomplete and contained large asynaptic and heterosynaptic zones. The rest of the nuclei contained only straight bivalents with heterosynapsis in the inverted regions (Borodin et al, 1 990a;Gorlov et al, 1991). In other words, in ml 2/ + males the population of cells in which chiasmata were able to arise in the regions of the inversion was rather restricted.…”

Section: Discussionmentioning

confidence: 99%

Recombination in single and double heterozygotes for two partially overlapping inversions in chromosome 1 of the house mouse

Gorlov

Бородин

1995

Heredity

Self Cite

View full text Add to dashboard Cite

Recombination frequency, chiasmata and chromatid interference were studied by means of analysis of meiotic configurations in diakinesis and metaphase II in single and double heterozygotes for the partially overlapping inversions In( 1 )lRk and In( 1)1 2Rk in chromosome 1 of the house mouse.Recombination frequency in the inverted regions was decreased in single heterozygotes and increased in the double heterozygotes as compared to normal homozygotes. Chiasmata in the inverted regions in the double heterozygotes did not interfere with each other. A significant excess of 4-chromatid double exchanges in the inverted regions was detected in the double heterozygotes.

show abstract

Positional control of chiasma distribution in the house mouse. Chiasma distribution in mice homozygous and heterozygous for an inversion in chromosome 1

Cited by 13 publications

References 35 publications

Meiotic Recombination Analyses in Pigs Carrying Different Balanced Structural Chromosomal Rearrangements

Meiotic Recombination Analyses in Pigs Carrying Different Balanced Structural Chromosomal Rearrangements

Synapsis and recombination of autosomes and sex chromosomes in two terns (Sternidae, Charadriiformes, Aves)

Recombination in single and double heterozygotes for two partially overlapping inversions in chromosome 1 of the house mouse

Contact Info

Product

Resources

About