Positional Isomeric Symmetric Dipodal Receptors Dangled with Rotatable Binding Scaffolds: Fluorescent Sensing of Silver Ions and Sequential Detection of l-Histidine and Their Multifarious Applications

Abstract

Three simple dipodal artificial acyclic symmetric receptors, SDO, SDM, and SDP, driven by positional isomerism based on xylelene scaffolds were designed, synthesized, and characterized by 1 H NMR, 13 C NMR, and mass spectroscopy techniques. Probes SDO, SDM, and SDP demonstrated selective detection of Ag + metal ions and amino acid L-histidine in a DMSO−H 2 O solution (1:1 v/v, HEPES 50 mM, pH = 7.4). The detection of Ag + metal ions occurred in three ways: (i) inhibition of the photoinduced electron-transfer (PET) process, (ii) blueshifted fluorescence enhancement via the intramolecular chargetransfer (ICT) process, and (iii) restricted rotation of the dangling benzylic scaffold following coordination with a Ag + metal ion. Job's plot analysis and quantum yields confirm the binding of probes to Ag +

Bacterial Cellulose–Based MOF Hybrid as a Sensitive Switch Off–On Luminescent Sensor for the Selective Recognition of l-Histidine

“…l -His, a common natural amino acid, generally exists at the enzyme catalytic site and has a considerable role in the growth and repair of tissues and the human central nervous system. − The presence of both the imidazole and amino acid functional groups in l -His molecule results in strong connections to certain transition metal ions such as Cu 2+ and controls the transport of metal ions in biological systems. , High levels of l -His in plasma induce some psychological disorder symptoms including epilepsy, Parkinson’s disease, and erythropoiesis. However, the lower levels of l -His cause a lot of diseases such as Alzheimer’s disease, chronic kidney disease, and lung disease. − …”

Magnetic Titanium Dioxide Nanocomposites as a Recyclable SERRS Substrate for the Ultrasensitive Detection of Histidine

“…Currently, there are various methods for detecting histidine, including fluorescence methods [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ], colorimetry method [ 15 , 16 , 17 , 18 , 19 ], electrochemistry [ 20 ], capillary electrophoresis (CE) [ 21 ], high-performance liquid chromatography (HPLC) [ 22 , 23 ], ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) [ 24 ] and gas chromatography–mass spectrometry (GC-MS) [ 25 , 26 ]. These methods have some limitations in practical applications to some extent.…”

A simple copper(ii) dppy-based receptor for sensing of l-cysteine and l-histidine in aqueous acetonitrile medium

“…On the other hand, an elevated level of His can result in liver cirrhosis, 21 asthma, 22 and other conditions. 23…”

“…On the other hand, an elevated level of His can result in liver cirrhosis, 21 asthma, 22 and other conditions. 23 Designing a receptor with a fast response, high sensitivity, and reliability for detecting and monitoring Cys and His concentrations can potentially aid in the early-stage recognition of various diseases. [24][25][26][27][28] In this context, several receptor analogues have been proposed for Cys and His recognition, including Schiff base, 29 1,8-naphthalimide, 30 benzothiazole, 31 coumarin, 32 fluorescein, 33 BODIPY, 34 α,β-unsaturated ketone, 35 rhodamine, 36 imidazole, 37 nanomaterials based receptors, 38 metal-organic frameworks (MOFs), 39 etc.…”