2006
DOI: 10.1016/j.imlet.2005.10.004
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Positioning prostanoids of the D and J series in the immunopathogenic scheme

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Cited by 80 publications
(62 citation statements)
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References 166 publications
(215 reference statements)
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“…In fact, nerve growth factor induces prostaglandin (PG) D 2 production in mast cells without causing degranulation (29,33). Since the final metabolite of PG known as 15-deoxy-delta 12,14-prostaglandin J 2 (15-deoxy-delta PGJ 2 ) is excreted daily in the urine, it has been suggested that this compound plays a role in homeostasis and diseases (18,25,41). Recent studies have demonstrated that the J 2 series of PGs act as natural ligands for the peroxisome proliferator-activated receptor (PPAR) ␥ and modulate glucose uptake in the fat tissue and skeletal muscle via the activation of PPAR␥ (4,12,14,25).…”
mentioning
confidence: 99%
“…In fact, nerve growth factor induces prostaglandin (PG) D 2 production in mast cells without causing degranulation (29,33). Since the final metabolite of PG known as 15-deoxy-delta 12,14-prostaglandin J 2 (15-deoxy-delta PGJ 2 ) is excreted daily in the urine, it has been suggested that this compound plays a role in homeostasis and diseases (18,25,41). Recent studies have demonstrated that the J 2 series of PGs act as natural ligands for the peroxisome proliferator-activated receptor (PPAR) ␥ and modulate glucose uptake in the fat tissue and skeletal muscle via the activation of PPAR␥ (4,12,14,25).…”
mentioning
confidence: 99%
“…One PG that may have an important implication in TED is PGD 2 . PGD 2 is a metabolite of arachidonic acid that is formed by the actions of cyclooxygenases and PGD 2 synthases (PGDS) (12,13). Many of the biological actions of PGD 2 are mediated through two G protein-coupled receptors: DP receptor 1 (DP1) and DP2 (also called chemoattractant receptor-homologous molecule (CRTH2)) (14 -16).…”
mentioning
confidence: 99%
“…L'activation du récepteur DP1 couplé à la protéine Gs induit la production du second messager AMPc stimulant la voie de la protéine kinase A (PKA) et induit également un flux calcique entrant [15]. L'activation du récepteur CRTH2 ou DP2, couplé à la protéine Gi, inhibe la production d'AMPc [16] et induit une mobilisation intracellulaire de Ca 2+ due à la production d'inositol triphosphate [4]. Selon le type cellulaire, les effets de la transduction du signal PGD2 via l'activation de ces deux récepteurs peuvent être synergiques ou antagonistes [2].…”
Section: La Transduction Du Signal De La Prostaglandine D2unclassified
“…L'effet anti-inflammatoire de la PGD2 a été attribué en grande partie à la 15d-PGJ2, un métabolite de la PGD2, qui est un ligand du récepteur nucléaire PPARγ (peroxisome proliferator-activated receptor g). La PGD2, via 15d-PGJ2 et PPARγ, est capable de supprimer la réponse immunogène en inhibant la production des cytokines (TNFα, IL-1α, IL-6) ou des médiateurs (iNOS) pro-inflammatoires [4]. De plus, la résolution de l'inflammation s'accompagne d'un shift de la biosynthèse de la prostaglandine E synthase (PGES) vers celle de la prostaglandine D synthase (PGDS) [24] ; la production résultante de PGD2 et de son métabolite 15d-PGJ2 contribuant à la résolution de l'inflammation.…”
Section: Les Rôles De La Prostaglandine D2unclassified
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