The COVID-19 pandemic has wreaked havoc on the tourism industry like never before, resulting in massive losses of revenue and jobs around the world. Accordingly, the pandemic exacerbated the already existing sustainability challenges of the tourism industry. However, there is also a positive side of the pandemic which is often overlooked by international scholarship. Thus, the present study aims to review the extant literature in the area of COVID-19 and the tourism industry’s sustainability and resilience in future crises. Through a synthesis of secondary data, it was possible to bring attention to the negative as well as the positive effects of COVID-19 on the global tourism industry. This article contributed to a better understanding of the positive side of the pandemic in terms of rethinking, resetting, and redefining the industry in a more sustainable way. The study lays out a conceptual framework for tourism managers and destination planners to identify the pandemic as an opportunity and adopt sustainable solutions to deal with the post-pandemic challenges, thereby developing more sustainable and resilient tourism businesses and destinations.