This chapter introduces the main parameters of the study, as well as the rationale, purpose and objectives of the book. It also presents an overview of the social and institutional context of the research topic, empowerment of at-risk VET students. We highlight the state of the art and current limitations of research on vocational integration and empowerment of at-risk youth in VET and working life. We also introduce the key concepts of our study, and the main theoretical frameworks applied, the socio-ecological approach and the resiliency or protective process approach, addressing also critical accounts to VET when it comes to students who are at-risk of social exclusion and marginalization. Further, the chapter describes our research methodology built on mixed methods design, closing with brief introductions to the book chapters.