Positive and negative symptoms in families with schizophrenia

Bassett, Anne S.; Collins, Evan; Nuttall, Sandra; Honer, William G.

doi:10.1016/0920-9964(93)90033-f

Cited by 54 publications

(47 citation statements)

References 45 publications

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“…Extensive geneological and psychiatric records were available. The ascertainment procedure maximized the likelihood that all patients would have a genetic form of schizophrenia, and because of the nature of the population, quite possibly a homogeneous form of the illness (Bassett et al 1993). This approach complements the high-risk studies that assessed genetic contributions to brain structure in schizophrenia (Cannon et al 1989(Cannon et al ,1993.…”

Section: Discussionmentioning

confidence: 99%

“…Details of the linkage study and subject recruitment are described elsewhere (Bassett et al 1993). Briefly, families were selected for large size, and an apparent autosomal-dominant like pattern of inheritance of psychosis.…”

Section: Subjectsmentioning

confidence: 99%

“…Parallel with efforts to isolate genes contributing to schizophrenia, research using schizophrenia pedigrees is providing important information about phenotypic aspects of the illness, including phenomenology (Bassett et al 1993(Bassett et al , 1994, neuropsychology (Roxborough et al 1993) and neurophysiology (Blackwood et al 1991;Waldo et al 1991). Neuroimaging studies of familial samples offer similar promise.…”

Section: Introductionmentioning

confidence: 99%

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Temporal lobe abnormalities in multigenerational families with schizophrenia

Honer

Bassett

Smith

et al. 1994

Biological Psychiatry

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Brain structure in familial schizophrenia was studied with computerized tomography in 42 individuals from six multigenerational families. Sulcal enlargement in the lateral temporal cortex, and ventricular and cisternal enlargement in the medial temporal region were observed in psychotic individuals compared to unaffected family members. Genetic factors in familial schizophrenia may exert part of their effect through determining or altering temporal lobe structure.

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Section: Discussionmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Temporal lobe abnormalities in multigenerational families with schizophrenia

Honer

Bassett

Smith

et al. 1994

Biological Psychiatry

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“…Bilineal families, with evidence from family or collateral history of schizophrenia or other non-affective psychotic disorders on both sides, were excluded. Further details of the original ascertainment and assessment for the linkage study are described elsewhere (Bassett et al, 1993).…”

Section: Samplementioning

confidence: 99%

Reproductive fitness in familial schizophrenia

Bassett¹,

McAlduff²,

Bury³

et al. 1995

Schizophrenia Research

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Background-Reproductive fitness is an important factor in understanding inheritance in genetic disorders. The purpose of this study was to determine whether fitness is reduced in familial schizophrenia (FS) and if fitness in siblings differs from the norm.Method-The number of offspring in 36 subjects with RDC schizophrenia or schizoaffective disorder (SZ) and their 101 siblings from large FS families was compared with age-adjusted census figures.Results-Fitness in the SZ group was significantly reduced: 23% of expected in males and 51% of expected in females. Fitness of unaffected siblings was within census expectations. However, female siblings with schizophrenia spectrum features had increased fitness over census norms. Reduced fitness was correlated with low marital rates, poor functioning and positive symptoms.Conclusions-These results indicate that reduced fitness is an important genetic force in FS and is likely inherent to the illness. Sex differences are important and would need to be considered when examining maternal and paternal transmission of schizophrenia. The results support a proposed high mutation rate for schizophrenia, consistent with a dynamic mutation mechanism.

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“…Details of the diagnostic and ascertainment procedures have been described previously. 29,30 In total, 85 subjects were considered affected under a narrow diagnostic classification (schizophrenia and schizoaffective disorder) and 125 subjects under a broad diagnostic classification that also includes nonaffective psychotic disorders, schizotypal personality disorder, and paranoid personality disorder. Of these families, 22 were used for the original genome scan.…”

Section: Subjectsmentioning

confidence: 99%

Tumor necrosis factor promoter haplotype associated with schizophrenia reveals a linked locus on 1q44

et al. 2004

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Using restriction fragment length polymorphism and pyrosequencing methods, we genotyped two TNFA gene promoter SNPs (ÀG308A, ÀG238A) and analyzed the haplotype structure in 24 Canadian families of primarily Celtic origin. Our results demonstrate that after correction for multiple testing based on simulations of 10 000 replicates of unlinked/unassociated data, there is evidence for association (P ¼ 0.026) of a specific haplotype (À308A, À238G) with schizophrenia and schizophrenia spectrum disorders with a family-based trimmed haplotype linkage disequilibrium test (Trimhap). Stratifying the 22 families with genome scan data by TNFA promoter haplotypes followed by reanalysis of linkage to schizophrenia throughout the genome, we identified few loci that exhibit a considerable increase in LOD/HLOD scores. A locus on chromosome 1q44 (D1S1609) demonstrated a significant increase (P ¼ 0.025) in LOD score from 0.15 to 3.01 with a broad definition of the schizophrenia phenotype and a dominant mode of inheritance. This result replicates a previously reported positive result of linkage of schizophrenia spectrum disorders to this area of the genome. We also illustrated that simulation studies are pivotal in evaluating the significance of results obtained with newer statistical methods, when multiple, but not independent, tests are performed, and when sample stratification is utilized to reduce the impact of heterogeneity or assess the interaction between loci.

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Positive and negative symptoms in families with schizophrenia

Cited by 54 publications

References 45 publications

Temporal lobe abnormalities in multigenerational families with schizophrenia

Temporal lobe abnormalities in multigenerational families with schizophrenia

Reproductive fitness in familial schizophrenia

Tumor necrosis factor promoter haplotype associated with schizophrenia reveals a linked locus on 1q44

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