Positive Anti-GABAB Receptor Antibodies in a Patient with Hashimoto’s Thyroiditis and Bipolar Affective Disorder

Abstract

A kind of autoimmune encephalitis with positive autoantibodies toward the B1 subunit of the gamma-aminobutyric acid-type B receptor is known as anti-GABABR encephalitis. It is an autoimmune brain disorder with typical manifestations of a limbic encephalitis. It can coexist with positive anti-thyroid autoantibodies. We described a 57-year-old woman who was diagnosed with a bipolar affective disorder. The patient had high titers of anti-thyroid peroxidase antibodies, and she also was positive for anti-GABABR antibodies. There is a question, if this case is a kind of comorbidity of anti-thyroid and anti-brain autoimmunity or is it a single nosological entity – a kind of Hashimoto’s encephalopathy?

Clinical Efficacy and Mechanism of Vitamin D2 in Treating Hashimoto’s Thyroiditis

“…Thus, blood 25OHD levels reflect vitamin D status from both diet and sunlight exposure. 7 Numerous studies have confirmed associations between HT and trace elements such as iodine and selenium; [8][9][10][11] however, the association between HT and vitamin D remains debatable.…”