Positive Association Between Body Mass Index and Hematologic Parameters, Including RBC, WBC and Platelet Count, in Korean Children and Adolescent

Jeong, Heisawn; Shim, Young Seok

doi:10.21203/rs.3.rs-576071/v1

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…In line with this increased erythroid oxidative damage, LP-OBIR + children also appeared to show increased osmotic fragility. Obesity has been related to higher Hb, red blood cell count and hematocrit [37], which is what we found in the late responder group. Hb and hematocrit are associated with higher risks of developing IR, T2DM and hyperuricemia [38][39][40].…”

Section: Discussionsupporting

confidence: 82%

Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance

González-Domínguez,

Belmonte,

Domínguez-Riscart

et al. 2023

J Transl Med

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Background Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other. There is currently no specific definition of IR in children, rather, that for adult population is used by pediatric endocrinologists instead. Altered insulin secretion dynamics are associated with worse metabolic profiles and type 2 diabetes mellitus development, thus we aimed to test whether insulin response relates to oxidative stress and inflammation in children. Methods We conducted a case–control study, including 132 children classified as follows: 33 children without obesity (Lean); 42 with obesity but no IR according to the American Diabetes Association criteria for adults (OBIR-); 25 with obesity and IR and an early insulin response to an oral glucose tolerance test (OGTT) (EP-OBIR +); 32 with obesity, IR, and a late insulin peak (LP-OBIR +); and studied variables associated with lipid and carbohydrate metabolism, oxidative stress, inflammation and inflammasome activation. Results The measured parameters of children with obesity, IR, and an early insulin response were similar to those of children with obesity but without IR. It was late responders who presented an impaired antioxidant system and elevated oxidative damage in erythrocytes and plasma, and inflammasome activation at their white blood cells, despite lower classical inflammation markers. Increased uric acid levels seems to be one of the underlying mechanisms for inflammasome activation. Conclusions It is insulin response to an OGTT that identifies children with obesity suffering oxidative stress and inflammasome activation more specifically. Uric acid could be mediating this pathological inflammatory response by activating NLRP3 in peripheral blood mononuclear cells. Graphical Abstract

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Section: Discussionsupporting

confidence: 82%

Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance

González-Domínguez,

Belmonte,

Domínguez-Riscart

et al. 2023

J Transl Med

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Section: Discussionmentioning

confidence: 99%

Altered Insulin Secretion Dynamics Relates to Oxidative Stress and Inflammasome Activation in Children with Obesity and Insulin Resistance

González-Domínguez,

Belmonte,

Domínguez-Riscart

et al. 2023

Preprint

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Background Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related with oxidative stress and inflammation which in turn promote each other. However, there is still no specific definition of IR in children. Altered insulin secretion dynamics are also related with worse metabolic profiles and type 2 diabetes mellitus development, thus we aimed to test whether if insulin response relates with oxidative stress and inflammation.Methods We conducted a case-control study, including 132 children (33 controls; 42 with obesity but no IR; 25 with obesity and IR and an early insulin response to OGTT; 32 with obesity, IR, and a late insulin peak), and studied variables related with lipid and carbohydrate metabolism, oxidative stress, inflammation and inflammasome activationResults Children with obesity and IR with an early insulin response, behaved much like those without IR an almost every parameter. It was late responders who presented an impaired antioxidant system and elevated oxidative damage in erythrocytes and plasma, and inflammasome activation at their white blood cells, despite lower classical inflammation markers. Increased uric acid levels seems to be one of the underlying mechanisms for inflammasome activation.Conclusions It is insulin response to an OGTT what better identifies children with obesity suffering oxidative stress and inflammasome activation. Uric acid could be mediating this pathological inflammatory response by activating NLRP3 in peripheral blood mononuclear cells.

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Positive Association Between Body Mass Index and Hematologic Parameters, Including RBC, WBC and Platelet Count, in Korean Children and Adolescent

Cited by 2 publications

References 30 publications

Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance

Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance

Altered Insulin Secretion Dynamics Relates to Oxidative Stress and Inflammasome Activation in Children with Obesity and Insulin Resistance

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