Positive Association Between IL-16 rs11556218 T/G Polymorphism and Cancer Risk: a Meta-analysis

Mo, Cuiju; Peng, Qiliu; He, Yu; Wang, Jian; Xie, Li; Li, Taijie; Li, Shan; Qin, Xue

doi:10.7314/apjcp.2014.15.11.4697

Cited by 15 publications

(13 citation statements)

References 33 publications

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“…The positive association was also observed in nasopharyngeal carcinoma 31 32 , prostate cancer 34 , and glioma 37 . Meta-analysis conducted by two independent groups confirmed these findings of IL16 rs11556218 increasing cancer risk 41 42 . In agreement with these results, we found that the rs11556218 TG/GG genotypes had a 1.66-fold increased risk of developing OS.…”

Section: Discussionmentioning

confidence: 56%

Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk

Tang

Wang

Xie

et al. 2016

Sci Rep

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Interleukin (IL) 16 plays a key role in inflammatory diseases as well as in tumorigenesis of osteosarcoma (OS). The aim of this study was to investigate the association of IL16 polymorphisms and plasma IL16 level with OS risk in a Chinese population. We genotyped IL16 rs4778889, rs11556218, and rs4072111 in 358 patients with OS and 402 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. Plasma IL16 level was measured by enzyme-linked immunosorbent assay. Rs11556218 was associated with an increased risk of OS in heterozygote comparison (adjusted OR = 1.65, 95% CI, 1.23–2.21, P < 0.001), dominant model (adjusted OR = 1.66, 95% CI, 1.24–2.21, P < 0.001), and allele comparison (adjusted OR = 1.44, 95% CI, 1.14–1.81, P = 0.002). Moreover, rs11556218 TG/GG genotypes were associated with higher levels of IL16 as compared to TT genotype (P = 0.03). However, no significant association of rs4778889 and rs4072111 and OS was found. These findings suggest that rs11556218 TG/GG genotypes may be associated with increased susceptibility to OS, probably by increasing the production of IL16 level.

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Section: Discussionmentioning

confidence: 56%

Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk

Tang

Wang

Xie

et al. 2016

Sci Rep

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“…The rs11556218 polymorphism is located on exon 6 of IL-16 gene, resulting in an asparagine to lysine substitution [19]. Previous studies have confirmed that rs11556218 polymorphism shows a significant association with a number of human cancers [30,31]. Inflammation is known to be associated with increased risk of cancer, and patients with T2DM have an increased inflammatory state and are also at increased risk of cancer [32,33].…”

Section: Discussionmentioning

confidence: 99%

Association ofIL-16gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population

et al. 2019

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Objective: The aim of the present study was to explore the genetic association of single nucleotide polymorphisms (SNPs) in interleukin-16 (IL-16) gene with type 2 diabetes mellitus (T2DM) susceptibility in a Chinese Han population. Methods: In total, 133 T2DM patients and 127 healthy controls matched by age and gender were recruited in the case–control study. IL-16 gene rs4778889 and rs11556218 polymorphisms were genotyped in the two groups via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Differences in genotype and allele distributions between groups were compared by the χ2 test. All the comparisons were adjusted for age, gender, and body mass index (BMI) by logistic regression. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the association strength between IL-16 gene polymorphism and T2DM risk. Results: The TG genotype and G allele frequencies of rs11556218 increased remarkably in the case group than that in controls (45.86 vs 33.86%; 29.70 vs 20.87%), and the differences reached a significant level (P<0.05). After adjusting for age, gender, and BMI, the differences still reached a significant level (P<0.05). Rs11556218 TG genotype carriers had a 1.769-fold increased risk of developing T2DM (OR = 1.769, 95% CI = 1.045–2.994), and G allele was also associated with an increased risk of T2DM (OR = 1.639, 95% CI = 1.087–2.471). IL-16 rs4778889 polymorphism showed no significant association with T2DM risk. Conclusion: IL-16 gene rs11556218 polymorphism was significantly associated with T2DM susceptibility in the Chinese Han population, while rs4778889 was not.

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“…[ 20 ] In the past few years, rs11556218 has been found to be associated with a wide range of conditions such as endometriosis, [ 21 ] Alzheimer's Disease, [ 22 ] emphysema, [ 23 ] coronary artery disease, [ 24 ] ischemic stroke, [ 25 ] systemic lupus erythematous, [ 26 ] chronic hepatitis B infection, [ 27 ] osteoarthritis, [ 20 ] overall cancer risk as well as particular cancer types. [ 28 ] SPEF2 stands for “Sperm Flagellar 2” gene which encodes for a protein that is required for correct axoneme development. [ 29 ] Even though the association of this gene with thrombosis and pancreatitis might seem counterintuitive, we are tempted to speculate that this might be mediated by the role this gene has in protein dimerization activity and the fact that the protein it encodes is significantly overexpressed in platelets.…”

Section: Discussionmentioning

confidence: 99%

Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients

Abaji

Gagné

et al. 2017

Oncotarget

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Allergy, pancreatitis and thrombosis are common side-effects of childhood acute lymphoblastic leukemia (ALL) treatment that are associated with the use of asparaginase (ASNase), a key component in most ALL treatment protocols. Starting with predicted functional germline variants obtained through whole-exome sequencing (WES) data of the Quebec childhood ALL cohort we performed exome-wide association studies with ASNase-related toxicities. A subset of top-ranking variants was further confirmed by genotyping (N=302) followed by validation in an independent replication group (N=282); except for thrombosis which was not available for that dataset. SNPs in 12 genes were associated with ASNase complications in discovery cohort including 3 that were associated with allergy, 3 with pancreatitis and 6 with thrombosis. The risk was further increased through combined SNPs effect (p≤0.002), suggesting synergistic interactions between the SNPs identified in each of the studied toxicities. Interestingly, rs3809849 in the MYBBP1A gene was associated with allergy (p= 0.0006), pancreatitis (p=0.002), thrombosis (p=0.02), event-free survival (p=0.02) and overall survival (p=0.003). Furthermore, rs11556218 in IL16 and rs34708521 in SPEF2 were both associated with thrombosis (p=0.01 and p=0.03, respectively) and pancreatitis (p=0.02). The association of SNPs in MYBBP1A, SPEF2 and IL16 geneswith pancreatitis was replicated in the validation cohort (p ≤0.05) as well as in combined cohort (p=0.0003, p=0.008 and p=0.02, respectively). The synergistic effect of combining risk loci had the highest power to predict the development of pancreatitis in both cohorts and was further potentiated in the combined cohort (p=1×10-8). The present work demonstrates that using WES data is a successful “hypothesis-free” strategy for identifying significant genetic markers modulating the effect of the treatment in childhood ALL.

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Positive Association Between IL-16 rs11556218 T/G Polymorphism and Cancer Risk: a Meta-analysis

Cited by 15 publications

References 33 publications

Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk

Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk

Association ofIL-16gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population

Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients

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