Positive association between insight and attitudes toward medication in Japanese patients with schizophrenia: Evaluation with the Schedule for Assessment of Insight (<scp>SAI</scp>) and the Drug Attitude Inventory – 10 Questionnaire (<scp>DAI</scp>‐10)

Ito, Seiichiro; Matsumoto, Junya; Sakai, Yoshie; Miura, Kenichiro; Hasegawa, Naomi; Yamamori, Hidenaga; Ishimaru, Keiichiro; Kim, Yoshiharu; Hashimoto, Ryota

doi:10.1111/pcn.13215

Cited by 4 publications

(9 citation statements)

References 8 publications

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“…1 Patients with schizophrenia have difficulty gaining insight. 2,3 They also show cognitive impairments. 4 Cognitive function plays an important role in patients’ functional outcomes.…”

Section: Introductionmentioning

confidence: 99%

Association Study Between White Matter Microstructure and Intelligence Decline in Schizophrenia

et al. 2021

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Patients with schizophrenia can exhibit intelligence decline, which is an important element of cognitive impairment. Previous magnetic resonance imaging (MRI) studies have demonstrated that patients with schizophrenia have altered gray matter structures and functional connectivity associated with intelligence decline defined by a difference between premorbid and current intelligence quotients (IQs). However, it has remained unclear whether white matter microstructures are related to intelligence decline. In the present study, the indices of diffusion tensor imaging (DTI) obtained from 138 patients with schizophrenia and 554 healthy controls were analyzed. The patients were classified into three subgroups based on intelligence decline: deteriorated (94 patients), preserved (42 patients), and compromised IQ (2 patients) groups. Given that the DTI of each subject was acquired using either one of two different MRI scanners, we analyzed DTI indices separately for each scanner group. In the comparison between the deteriorated IQ group and the healthy controls, differences in some DTI indices were noted in three regions of interest irrespective of the MRI scanners, whereas differences in only one region of interest were noted between the preserved IQ group and the healthy controls. However, the comparisons between the deteriorated and preserved IQ groups did not show any reproducible differences. Together with the previous findings, it is thought that gray matter structures and functional connectivity are more promising as markers of intelligence decline in schizophrenia than white matter microstructures.

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“…1 Patients with schizophrenia have difficulty gaining insight. 2,3 They also show cognitive impairments. 4 Cognitive function plays an important role in patients’ functional outcomes.…”

Section: Introductionmentioning

confidence: 99%

Association Study Between White Matter Microstructure and Intelligence Decline in Schizophrenia

et al. 2021

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“…Lack of insight is a commonly observed symptom in patients with schizophrenia, which leads to poor adherence to treatment even when diagnosed. 155 A diagnosis based on objective tests, rather than a subjective diagnosis based on psychiatrists' experience, makes it easier for patients to adhere to treatment at any stage of the disease process. Thus, the development of objective diagnostic methods can lead to earlier therapeutic interventions, which can facilitate recovery.…”

Section: Discussionmentioning

confidence: 99%

“…Concerning the development of objective diagnostic methods (e.g., cognitive function, eye movements, neuroimaging, and neurophysiology), it is expected that accurate diagnoses can be made earlier. Lack of insight is a commonly observed symptom in patients with schizophrenia, which leads to poor adherence to treatment even when diagnosed 155 . A diagnosis based on objective tests, rather than a subjective diagnosis based on psychiatrists' experience, makes it easier for patients to adhere to treatment at any stage of the disease process.…”

Section: Discussionmentioning

confidence: 99%

Toward recovery in schizophrenia: Current concepts, findings, and future research directions

Onitsuka

Hirano

Nakazawa

et al. 2022

Psychiatry Clin Neurosci

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Schizophrenia was initially defined as “dementia praecox” by E. Kraepelin, which implies progressive deterioration. However, recent studies have revealed that early effective intervention may lead to social and functional recovery in schizophrenia. In this review, we provide an overview of current concepts in schizophrenia and pathophysiological hypotheses. In addition, we present recent findings from clinical and basic research on schizophrenia. Recent neuroimaging and neurophysiological studies have consistently revealed specific biological differences in the structure and function of the brain in those with schizophrenia. From a basic research perspective, to determine the essential pathophysiology underlying schizophrenia, it is crucial that findings from all lines of inquiry—induced pluripotent stem cell (iPSC)‐derived neural cells from patients, murine models expressing genetic mutations identified in patients, and patient clinical data—be integrated to contextualize the analysis results. However, the findings remain insufficient to serve as a diagnostic tool or a biomarker for predicting schizophrenia‐related outcomes. Collaborations to conduct clinical research based on the patients' and their families' values are just beginning, and further development is expected.

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“…There have been numerous studies of insight using these scales. 18 , 19 , 20 , 21 A lack of insight is a common feature of patients with schizophrenia, 12 and it has been estimated that approximately 50%–80% of patients are unaware of their illness. 13 Insight has been linked to treatment adherence, 22 , 23 medication attitudes, 19 and prognosis 15 ; therefore, understanding insight is important.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal characteristics of insight and clinical factors in patients with schizophrenia

Sakai

Ito

Matsumoto

et al. 2023

Neuropsychopharm Rep

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AimsSchizophrenia is a psychiatric disorder presenting a lack of insight. Although insight changes over time, longitudinal studies of insight in schizophrenia are scarce. Furthermore, most previous studies on insight and intelligence have not measured full‐scale IQ and have not been able to examine the relationship between detailed dimensions of cognitive function and insight. In this study, we assessed insight at two time points and assessed dimensions of cognitive function.MethodsA total of 163 patients with schizophrenia participated in the study. We evaluated insight at two time points to understand the patterns of change and examined the association between insight and clinical variables. Additionally, we examined the relationship between the dimensions of cognitive function and insight.ResultsThe patients were divided into three groups based on their change in insight over time: stable at a low level of insight (poor insight), stable at a high level of insight (good insight), and changed in insight over time (unstable insight). Those in the poor insight group had lower general intelligence scores than those in the good insight and unstable insight groups. Regarding cognitive function, verbal comprehension was associated with the level of insight at baseline and follow‐up. Regarding psychiatric symptoms, the poor insight group exhibited more severe symptoms than the other two groups, especially regarding positive symptoms.ConclusionsOur classification of patients based on changes in insight revealed that poor insight patients had impaired cognitive function, especially verbal comprehension, and more severe positive symptoms than good insight or unstable insight patients.

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Positive association between insight and attitudes toward medication in Japanese patients with schizophrenia: Evaluation with the Schedule for Assessment of Insight (SAI) and the Drug Attitude Inventory – 10 Questionnaire (DAI‐10)

Cited by 4 publications

References 8 publications

Association Study Between White Matter Microstructure and Intelligence Decline in Schizophrenia

Association Study Between White Matter Microstructure and Intelligence Decline in Schizophrenia

Toward recovery in schizophrenia: Current concepts, findings, and future research directions

Longitudinal characteristics of insight and clinical factors in patients with schizophrenia

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