Positive association between soil arsenic concentration and mortality from alzheimer’s disease in mainland China

Li, Xuelian; Zhan, Runqing; Zheng, Wei; Jiang, Hong; Zhang, Dongfeng; Shen, Xiaoli

doi:10.1016/j.jtemb.2020.126452

Cited by 11 publications

(5 citation statements)

References 43 publications

(49 reference statements)

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“…In vivo studies showed that excessive exposure to As induced neuronal apoptosis, which interrupted the neurodevelopment and cognitive functions of rats [ 163 , 164 , 165 ]. Epidemiological studies in rural-dwelling adults and elders also show that As (3–15 µg/L) levels in water negatively correlated with the scores of cognitive performance and memory, indicating that As is a neurotoxic metalloid [ 166 ], which also acts as a risk factor for AD [ 33 , 167 , 168 , 169 ]. However, the mechanisms of As-induced neurotoxicity remain unclear.…”

Section: Molecular Mechanisms Of Metal-induced Mitochondrial Dysfunctionmentioning

confidence: 99%

Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders

Cheng

Yang

Tao

et al. 2021

Toxics

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Metals are actively involved in multiple catalytic physiological activities. However, metal overload may result in neurotoxicity as it increases formation of reactive oxygen species (ROS) and elevates oxidative stress in the nervous system. Mitochondria are a key target of metal-induced toxicity, given their role in energy production. As the brain consumes a large amount of energy, mitochondrial dysfunction and the subsequent decrease in levels of ATP may significantly disrupt brain function, resulting in neuronal cell death and ensuing neurological disorders. Here, we address contemporary studies on metal-induced mitochondrial dysfunction and its impact on the nervous system.

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Section: Molecular Mechanisms Of Metal-induced Mitochondrial Dysfunctionmentioning

confidence: 99%

Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders

Cheng

Yang

Tao

et al. 2021

Toxics

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“…However, the hypothesis and molecular mechanisms of arsenic-related pathology in Alzheimer are still unclear 5 . In an ecological study by Li et al 27 , the association between exposures to contaminated soil and the death rate due to Alzheimer was investigated, and the relative risk (RR) and Spearman's correlation coefficient were calculated using based on10-year Alzheimer's mortality data. Based on the results, in the areas where the average concentrations of arsenic were 9.05, 10.4, and 13.1 μg/L, relative risks were calculated and found to be 4.3 (CI 4.3–4.39), 6.1 (CI 6.04–6.17), and 9.1 (CI 9.03–9.2), respectively 27 .…”

Section: Discussionmentioning

confidence: 99%

The association of arsenic exposure with mortality due to cancer, diabetes, Alzheimer's and congenital anomalies using Poisson regression

Rahmani,

Khamutian,

Doosti-Irani

et al. 2023

Sci Rep

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The present study aims to determine the relationship between the concentration of arsenic in the groundwater of Hamadan province and the mortality rate due to various types of malignancies, congenital anomalies, diabetes mellitus and Alzheimer's. Mortality data due to various causes of death in Hamadan province were collected for five years (2016–2020). Sampling of drinking water was determined in the reference laboratory using polarography method. Poisson regression was used to investigate the relationship between arsenic level and the death rate due to various types of disease, at a significant level (p value < 0.05). According to the results of Poisson regression, among the various causes of death (N = 8042), Alzheimer's 5.94 (3.67–9.61), diabetes mellitus 4.05 (3.5–5.37), congenital malformations 2.98 (1.88–4.72), breast cancer 2.72 (1.56–4.71), leukemia 1.90 (1.24–2.92), stomach cancer 1.64 (1.28–2.10), Liver cancer 1.58 (1.58–2.30), other digestive organs 5.86 (3.38–10.16), meninges and brain cancer 1.57 (1.02–2.41) showed the highest relationship with arsenic contamination. The results of this study could be evidence for a positive and significant relationship between arsenic concentrations and mortality rates due to cancers, diabetes mellitus, Alzheimer disease, and congenital malformations. Therefore, it's necessary to use appropriate water treatment methods to remove arsenic at the source in contaminated areas.

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“…The studies that analyzed serum arsenic did not find an association with AD [ 44 , 45 ], while greater arsenic in nail and hair of AD patients was reported [ 46 ]. There is evidence that arsenic accumulates in the brains of rodents [ 47 , 48 ] and humans [ 49 , 50 ]. Exposure to arsenic causes brain damages such as neuronal necrosis and apoptosis [ 51 ], oxidative stress [ 52 ], Tau hyperphosphorylation [ 28 ], and transcriptional activation of Aβ precursor protein gene [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Alzheimer’s Disease Association with Metals and Metalloids Concentration in Blood and Urine

Strumylaitė

Kregždytė

Kučikienė

et al. 2022

IJERPH

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As there is some evidence that the risk for Alzheimer’s disease (AD) is partially attributable to environmental exposure to some metals and metalloids, we examined an association between AD and arsenic, chromium, and selenium in 53 AD patients and 217 controls. Urinary arsenic, blood chromium, and selenium were determined by inductively coupled plasma mass spectrometry. Logistic regression models calculating odds ratios (ORs) and 95% confidence intervals (CI) were used to estimate AD association with arsenic, chromium, and selenium. In AD patients, urinary arsenic and blood chromium were significantly higher, while blood selenium was significantly lower compared to controls. Increased blood selenium was related to a significant decrease in the odds of AD after adjustment for risk factors. Blood selenium per 1 kg × 10−9/m3 × 10−4 increment was associated with 1.4 times lower risk of AD (OR = 0.71; 95% CI 0.58–0.87). A significant increase in the odds of AD associated with increased blood chromium was also seen in the adjusted model: the OR per 1 kg × 10−9/m3 × 10−3 chromium increment was 2.39 (95% CI 1.32–4.31). The association of urinary arsenic with the risk of AD was not significant. The data obtained provide evidence that selenium reduces the risk of Alzheimer’s disease, while chromium increases it.

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Positive association between soil arsenic concentration and mortality from alzheimer’s disease in mainland China

Cited by 11 publications

References 43 publications

Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders

Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders

The association of arsenic exposure with mortality due to cancer, diabetes, Alzheimer's and congenital anomalies using Poisson regression

Alzheimer’s Disease Association with Metals and Metalloids Concentration in Blood and Urine

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