Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

Abstract

Background: Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients.Methods: This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV). Results: The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively correlated with baPWV (β, 0.97; 95% confidence interval [CI] 0.78, 1.17). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.03; 95% CI 1.70, 2.41). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05).Conclusion: TyG index was independently and positively correlated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.

Association between insulin resistant surrogate index and arterial stiffness in hypertensive population: a five year follow-up cohort study

“…However, these studies are all based on general populations. Recently, Li et al [19] , found that TyG index is positively associated with arterial stiffness in hypertension patients. However, this study is a cross-sectional study, which makes the causality unclear.…”

The relationship between the atherogenic index of plasma and arterial stiffness in essential hypertensive patients from China: a cross-sectional study

“…Participants were not permitted to consume tea, alcohol, coffee, or cigarettes for 30 min prior to testing. The measurement approaches of baPWV and ABI related to this study have been described previously [25]. Four cufs were wrapped around ankles and bilateral brachia followed by their connection to an oscillometric pressure sensor and plethysmographic sensor.…”

The Relationship Between the Atherogenic Index of Plasma and Arterial Stiffness in Essential Hypertensive Patients from China: A Cross-Sectional Study

“…Participants were not permitted to consume tea, alcohol, coffee, or cigarettes for 30 minutes prior to testing. The measurement approaches of baPWV and ABI related to this study have been described previously [24]. Four cufs were wrapped around ankles and bilateral brachia followed by their connection to an oscillometric pressure sensor and plethysmographic sensor.…”