Positive Association between Triglyceride-Rich Lipoprotein Cholesterol and Diabetes Mellitus in Hypertensive Patients

Abstract

Background. The association between triglyceride-rich lipoprotein cholesterol (TRL-C) and diabetes mellitus (DM) remains unclear because of limited research and data. The aim of this study was to explore the independent association between TRL-C and DM in hypertensive patients and to examine whether a healthy lifestyle would have an impact on this relationship. Methods. In this study, data from 13,721 hypertensive patients who were not treated with lipid-lowering drugs were analyzed. TRL-C was calculated from total cholesterol (TC) minus [LDL cholesterol + HDL cholesterol]. DM was defined as fasting plasma glucose of ≥7.0 mmol/L and/or self-reported history of hypoglycemic drug use. Results. After adjusting for potential confounding factors, the TRL-C was significantly positively associated with elevated DM (odds ratio (OR): 1.73 and 95% confidence interval (CI): 1.54–1.94). In subgroup analysis, a healthy lifestyle (HL) failed to modify the positive association between TRL-C and DM (HL: OR 1.93, 95%CI 1.58–2.36; non-HL: OR 1.72, 95%CI 1.50–1.98; P for interaction = 0.38). Conclusion. The results showed a positive association between TRL-C and DM in hypertensive patients. A healthy lifestyle failed to diminish the relationship between TRL-C and DM. The novel findings indicate that TRL-C might be a reliable marker of DM and may provide a new strategy for the prevention and treatment of DM.

Remnant cholesterol is independently associated with diabetes, even if the traditional lipid is at the appropriate level: A report from the REACTION study

“…The present study also found that RC and diabetes remained strongly associated regardless of whether the participant was overweight or not. Zhou et al 21 found a positive correlation between RC and diabetes in 13 721 hypertensive patients; however, RC and diabetes were associated only in persons with normal blood pressure in the current investigation. We speculate that this is because the number of hypertension patients in the current research was modest in comparison to Zhou's team's investigation.…”

“…Szili‐Torok et al 20 analyzed 480 patients who had undergone kidney transplantation, and they found a significant association between RC and new‐onset diabetes after kidney transplantation. Zhou et al 21 found a positive correlation between RC and diabetes in 13 721 Chinese hypertensive patients. Nevertheless, the current study population was the large sample general Chinese population, including subjects with various chronic diseases and healthy subjects; hence, the findings of the current study were more generally applicable.…”

Correlation of Triglyceride-Rich Lipoprotein Cholesterol and Diabetes Mellitus in Stroke Patients

“…In the Cox model with adjusted basic covariates, TRL-c significantly correlated with diabetes (HR = 1.39, 95% CI 1.28–1.51, P < 0.001). Zhou Wei et al [ 9 ] in China conducted a cross-sectional analysis of the data of 13,721 hypertensive patients without lipid-lowering drugs. They found that TRL-c significantly and positively correlated with diabetes risk (OR = 1.73, 95% CI: 1.54–1.94).…”

“…Moreover, a positive correlation between TRL-c and diabetes has been investigated in recently published studies [ 8 , 9 ]. However, the results obtained from another study suggested no correlation [ 10 ].…”