Positive association of a Sirt1 variant and parameters of oxidative stress on Alzheimer’s disease

Camporez, Daniela; Belcavello, Luciano; Almeida, Jucimara Ferreira Figueiredo; Sena, Geralda Gillian Silva; Pimassoni, Lucia Helena Sagrillo; Morelato, Renato Lírio; Batitucci, Maria do Carmo Pimentel; Paula, Fabiana Martins de

doi:10.1007/s10072-020-04704-y

Cited by 17 publications

(15 citation statements)

References 60 publications

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“…However, in the absence of the APOE-ε4 allele, there was no risk of developing either AD or aMCI [ 90 ], implying that having the rs-4880 allele alone is not an AD risk. It is worth noting that several investigations [ 88 , 91 ] have corroborated the previous finding. Therefore, we speculate that having the APOE-ε4 allele may cause antioxidant dysfunctionality of the SOD gene, especially in those carrying the rs-4880 variant, and increase their risk of AD.…”

Section: Apolipoprotein E: Function and Role In Adsupporting

confidence: 77%

Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents

Botchway¹,

Okoye²,

Chen³

et al. 2022

Aging and disease

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Alzheimer’s disease (AD) is a current public health challenge and will remain until the development of an effective intervention. However, developing an effective treatment for the disease requires a thorough understanding of its etiology, which is currently lacking. Although several studies have shown the association between oxidative damage and AD, only a few have clarified the specific mechanisms involved. Herein, we reviewed recent preclinical and clinical studies that indicated the significance of oxidative damage in AD, as well as potential antioxidants. Although several factors regulate oxidative stress in AD, we centered our investigation on apolipoprotein E and the gut microbiome. Apolipoprotein E, particularly apolipoprotein E-ε4, can impair the structural facets of the mitochondria. This, in turn, can minimize the mitochondrial functionality and result in the progressive build-up of free radicals, eventually leading to oxidative stress. Similarly, the gut microbiome can influence oxidative stress to a significant degree via its metabolite, trimethylamine N-oxide. Given the various roles of these two factors in modulating oxidative stress, we also discuss the possible relationship between them and provide future research directions.

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Section: Apolipoprotein E: Function and Role In Adsupporting

confidence: 77%

Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents

Botchway¹,

Okoye²,

Chen³

et al. 2022

Aging and disease

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“…To explore this possibility, we have used a pathway analysis approach in MetaCore as previously described [ 12 ]. Results from this pathway analysis indeed support that possibility by identifying a plausible ten-member network where all ten members have been implicated in AD: APOE [ 13 ], ACE2 [ 14 ], CTNNB1 [ 15 ], NOTCH1 [ 16 , 17 ], LZTFL1 [ 18 ], MMP1 [ 19 ], NRP1 [ 20 ], RELA [ 21 ], SIRT1 [ 22 ], and MMP14 [ 19 ] ( left panel in Fig. 1 ).…”

Section: Pathway Support For a Role Of Apoe4 In The Severity Of Covid-19mentioning

confidence: 52%

Severe COVID-19 in Alzheimer’s disease: APOE4’s fault again?

Xiong

Schiller

et al. 2021

Alz Res Therapy

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Challenges have been recognized in healthcare of patients with Alzheimer’s disease (AD) in the COVID-19 pandemic, given a high infection and mortality rate of COVID-19 in these patients. This situation urges the identification of underlying risks and preferably biomarkers for evidence-based, more effective healthcare. Towards this goal, current literature review and network analysis synthesize available information on the AD-related gene APOE into four lines of mechanistic evidence. At a cellular level, the risk isoform APOE4 confers high infectivity by the underlying coronavirus SARS-CoV-2; at a genetic level, APOE4 is associated with severe COVID-19; at a pathway level, networking connects APOE with COVID-19 risk factors such as ACE2, TMPRSS2, NRP1, and LZTFL1; at a behavioral level, APOE4-associated dementia may increase the exposure to coronavirus infection which causes COVID-19. Thus, APOE4 could exert multiple actions for high infection and mortality rates of the patients, or generally, with COVID-19.

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“…Both GLO1 and SOD2 polymorphisms have been associated with modifications of their enzymatic activity and increased susceptibility to oxidative stress [ 24 ]. Associations of the apolipoprotein (APO)E4 allele, a well-known risk factor for sporadic AD, and oxidative stress-related gene polymorphisms, in particular SOD2, may provide additional risk in AD and MCI [ 14 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Gene- and Gender-Related Decrease in Serum BDNF Levels in Alzheimer’s Disease

Piancatelli

Aureli

Sebastiani

et al. 2022

IJMS

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Brain-derived neurotrophic factor (BDNF) has a protective role in Alzheimer’s disease (AD). Oxidative stress and inflammatory cytokines are potentially implicated in AD risk. In this study, BDNF was detected in serum of AD and mild cognitive impairment (MCI) patients and investigated in association with gene polymorphisms of BDNF (Val66Met and C270T), of some oxidative stress-related genes (FOXO3A, SIRT3, GLO1, and SOD2), and of interleukin-1 family genes (IL-1α, IL-1β, and IL-38). The APOE status and mini-mental state examination (MMSE) score were also evaluated. Serum BDNF was significantly lower in AD (p = 0.029), especially when comparing the female subsets (p = 0.005). Patients with BDNFVal/Val homozygous also had significantly lower circulating BDNF compared with controls (p = 0.010). Moreover, lower BDNF was associated with the presence of the T mutant allele of IL-1α(rs1800587) in AD (p = 0.040). These results were even more significant in the female subsets (BDNFVal/Val, p = 0.001; IL-1α, p = 0.013; males: ns). In conclusion, reduced serum levels of BDNF were found in AD; polymorphisms of the IL-1α and BDNF genes appear to be involved in changes in serum BDNF, particularly in female patients, while no effects of other gene variants affecting oxidative stress have been found. These findings add another step in identifying gender-related susceptibility to AD.

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Positive association of a Sirt1 variant and parameters of oxidative stress on Alzheimer’s disease

Cited by 17 publications

References 60 publications

Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents

Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents

Severe COVID-19 in Alzheimer’s disease: APOE4’s fault again?

Gene- and Gender-Related Decrease in Serum BDNF Levels in Alzheimer’s Disease

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