Positive association of high-density lipoprotein cholesterol with lumbar and femoral neck bone mineral density in postmenopausal women

Zolfaroli, Irene; Ortiz, Ester; Garcı́a-Pérez, Miguel A.; Hidalgo-Mora, Juan José; Tarı́n, Juan J.; Cano, Antonio

doi:10.1016/j.maturitas.2021.03.001

Cited by 31 publications

(30 citation statements)

References 35 publications

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“…Study has proved that lignans can affect postmenopausal osteoporosis through primary bile acid biosynthesis ( 66 ). It is reported that cholesterol content positively associated with bone mineral density of postmenopausal women ( 67 ). Thus, THLs could putatively exert a major metabolic effect on improving bone loss through arachidonic acid metabolism, serotonergic synapse, primary bile acid biosynthesis, and cholesterol metabolism.…”

Section: Discussionmentioning

confidence: 99%

Tilapia nilotica Head Lipids Improved Bone Loss by Regulating Inflammation and Serum Metabolism Through Gut Microbiota in Ovariectomized Rats

et al. 2022

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Osteoporosis is a global health problem, and it is of great significance to replace the drugs with natural functional factors. In this study, we investigated the antiosteoporotic activity of lipids prepared from Tilapia nilotica fish head lipids (THLs) in the ovariectomized osteoporosis rats. THLs are composed of neutral lipids (NL, 77.84%), phospholipids (PL, 11.86%), and glycolipids (GL, 6.47%). There were apparent differences in the fatty acid composition of disparate components, and PL contains the most abundant Ω-3 polyunsaturated fatty acids. The results proved that THLs could improve bone microstructure, increase bone mineral density, and decrease bone resorption. To illustrate the antiosteoporotic mechanism, we analyzed the changes in gut microbial communities, proinflammation factors, serum metabolites, and metabolic pathways. Further study on gut microbiota showed that THLs significantly decreased the content of Alistipes in the gut and dramatically increased the beneficial bacteria such as Oscillospira, Roseburia, and Dubosiella. Meanwhile, proinflammation factors of serum in OVX rats decreased significantly, and metabolites were changed. Therefore, we speculated that THLs improved bone loss through reducing inflammation and changing the metabolites and metabolic pathways such as arachidonic acid metabolism and primary bile acid metabolism, etc., by altering gut microbiota. The results indicated that THLs could be a functional factor with antiosteoporotic activity.

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Section: Discussionmentioning

confidence: 99%

Tilapia nilotica Head Lipids Improved Bone Loss by Regulating Inflammation and Serum Metabolism Through Gut Microbiota in Ovariectomized Rats

et al. 2022

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“…A decline in E2 level has been recognized as the most critical hormonal regulator of the menopause-associated decrease in BMD [ 17 ]. A study from Spain reported a positive association between E2 levels and BMD [ 18 ]. In a study of 132 women with postmenopausal osteoporosis and 81 postmenopausal women without osteoporosis, serum concentrations of E2 were found to be significantly lower in the osteoporosis group, indicative of a positive correlation between E2 and BMD [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Association between serum estradiol level, sex hormone binding globulin level, and bone mineral density in middle-aged postmenopausal women

et al. 2021

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Background Changes in sex hormones are thought to play an important role in bone health in postmenopausal women. Our aim in this study was to evaluate the association between levels of estradiol (E2), which is the most potent endogenous estrogen, and sex hormone binding globulin (SHBG) and bone mineral density (BMD) among postmenopausal women, 40–59 years of age. Methods Using data from the National Health and Nutrition Examination Survey 2013–2016, we performed weighted multivariable linear regression models to evaluate the associations between serum levels of E2 and SHBG and lumbar BMD. A weighted generalized additive model and smooth curve fitting were used to address potential nonlinearity. Results A total of 608 postmenopausal women were included in the analysis. The serum E2 level was positively associated with lumbar BMD, after adjusting for other covariates (β 0.65; 95% confidence interval (CI) 0.38–0.93). An inverted U-shaped association between the serum E2 level and lumbar BMD was further identified, with the point of inflection at an E2 level of 70 pg/mL. There was no significant association between the SHBG level and lumbar BMD (β 0.01; 95% CI − 0.30 to 0.31). However, the association between these two variables was U-shaped, with the point of inflection at an SHBG level of 65 nmol/L. Conclusions Based on our findings, it may be beneficial to appropriately increase serum E2 levels to promote bone health in postmenopausal women with low estrogen levels. Considering the inverted U-shaped association, an excessive E2 level may be harmful to BMD. In addition, increasing the SHBG level to within the normal range (65–144 nmol/L) may be considered.

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“…Samelson et al (22) believe that the cholesterol levels of people in young adulthood to middle age do not have long-term clinical signi cance for later osteoporosis. However, the research of Zolfaroli (23) suggests that there is a positive correlation between cholesterol and BMD in the lumbar spine and femoral neck in postmenopausal women. Other researchers have found a moderate negative correlation between BMD and serum cholesterol levels (17).…”

Section: Discussionmentioning

confidence: 99%

Associations Between Serum Total Cholesterol Level and Bone Mineral Density in Older Adults

Zhang

Wang

et al. 2021

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Background: Osteoporosis is a major clinical problem in elderly people. The correlation between total cholesterol and bone mineral density remains controversial.Methods: We obtained records from the National Health and Nutrition Examination Survey (NHANES) database for 4236 people aged over 60 without a diagnosis of cancer. We analyzed the relationship between total cholesterol and lumbar bone mineral density, using the statistical packages R and Empower Stats. We described the research population and performed stratified and single factor analysis, multiple equation regression analysis, smooth curve fitting, and threshold effect and saturation effect analysis.Results: A significant negative association was found between serum cholesterol levels and bone mineral density of the lumbar spine in the study population. Older adults ≥70 years of age had an inflection point at 280 mg / dl, and those with moderate physical activity had an inflection point at 203 mg / dl. The smooth curves fitted were all U-shaped.Conclusions: There is a negative association between total cholesterol and lumbar spine bone mineral density in people without cancer aged 60 or older.

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Positive association of high-density lipoprotein cholesterol with lumbar and femoral neck bone mineral density in postmenopausal women

Cited by 31 publications

References 35 publications

Tilapia nilotica Head Lipids Improved Bone Loss by Regulating Inflammation and Serum Metabolism Through Gut Microbiota in Ovariectomized Rats

Tilapia nilotica Head Lipids Improved Bone Loss by Regulating Inflammation and Serum Metabolism Through Gut Microbiota in Ovariectomized Rats

Association between serum estradiol level, sex hormone binding globulin level, and bone mineral density in middle-aged postmenopausal women

Associations Between Serum Total Cholesterol Level and Bone Mineral Density in Older Adults

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