Positive associations between sex hormones, bone metabolism and cognitive impairment in Chinese oldest-old females

Feng, Long; Bian, Lihua; Ning, Chaoxue; Zhang, Pei; Zhao, Yali; Zhi, Gao; Ping, Ping; Fu, Shihui

doi:10.1186/s12888-023-04957-9

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…A supplementing with 25(OH)D3 might increase serum 25(OH)D3 and testosterone level in obese mice 53 . Bioavailable testosterone presented a positive association of cognitive function in older men 54 , while prolactin, progesterone and estradiol might have deleterious effects on cognitive function in older females after menopause 55 , 56 . However, the number of patients in our subgroup is relatively limited, and the insignificance may be due to the small sample size.…”

Section: Discussionmentioning

confidence: 94%

Association between serum 25-hydroxyvitamin D3 level and cognitive impairment in older chronic kidney disease patients

Zhang,

Zhang

2024

Sci Rep

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This study aims to examine whether hypovitaminosis D was associated with cognitive impairment among chronic kidney patients with different level of albuminuria. This population-based cross-sectional study was conducted on elderly (over 60 years old) with urine albumin to creatinine ratio (UACR) ≥ 30 mg/g from 2011 to 2014 in the US National Health and Nutrition Examination Survey (NHANES). Cognitive function was assessed by the Consortium to Establish a Registry for Alzheimer’s Disease Word List Learning (CERAD). Subjects were divided into 2 groups according to the absence or presence of cognitive impairment and a propensity score matching (PSM) was further conducted. The association was assessed with Spearman correlation and logistic regression analysis. The positive association of 25-hydroxyvitamin D3 (25(OH)D3) and cognitive score was presented. PSM analysis revealed that a higher level of 25(OH)D3 correlated to a better cognitive function in CKD patients with albuminuria, especially in patients with 30 mg/g ≤ UACR < 300 mg/g. This study indicated that a low 25(OH)D3 level was associated with poor cognitive performance, especially in patients with microalbuminuria. Thus, early diagnosis of vitamin D insufficiency and an effective intervention might be a useful therapeutic strategy to prevent cognitive decline in patients with the progression of renal dysfunction.

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Section: Discussionmentioning

confidence: 94%

Association between serum 25-hydroxyvitamin D3 level and cognitive impairment in older chronic kidney disease patients

Zhang,

Zhang

2024

Sci Rep

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“…This study found that psychological resilience played a protective role in survival outcomes for the oldest-old in China. The oldest-old often face various sources of stress, such as health issues related to physical frailty, economic burdens associated with caregiving, and social isolation ( 37 , 38 ). These negative events require a strong psychological resilience to adopt appropriate solutions.…”

Section: Discussionmentioning

confidence: 99%

Impact of lifestyle and psychological resilience on survival among the oldest-old in China: a cohort study

Cai,

Gao,

et al. 2023

Front. Public Health

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IntroductionHealthy lifestyles and psychological resilience are important factors influencing the life expectancy of the oldest-old (≥80 years). Stratified by urban and rural groups, this study used a 10-year cohort to examine the mechanism of lifestyle and psychological resilience on the survival of the oldest-old in China.MethodsThis study used the China Longitudinal Healthy Longevity Survey datasets spanning from 2008 to 2018, and 9,250 eligible participants were included. The primary outcome variable was all-cause mortality, and independent variables included healthy lifestyle index and psychological resilience. Six covariates were included in the survival analysis and moderation-mediation model, such as gender and annual household income.ResultsThis study found that the oldest-old with five healthy lifestyles had the longest survival time, averaging 59.40 months for urban individuals and 50.08 months for rural individuals. As the lifestyle index increased, the survival rate significantly increased. The Cox regression showed that for the urban oldest-old, the lifestyle index served as a protective factor for survival outcomes. However, this effect lost statistical significance among rural oldest-old individuals. For urban oldest-old individuals, psychological resilience significantly mediated and moderated the effect of the lifestyle index on survival status, but the moderating effect was not statistically significant for the rural ones.DiscussionOverall, healthy lifestyles and psychological resilience can be effective in enhancing the survival of the oldest-old, and there are differences between urban and rural population, so different interventions should be adopted for urban and rural areas to achieve longer life in China.

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Development and Validation of the Communities Geriatric Mild Cognitive Impairment Risk Calculator (CGMCI-Risk)

Chen,

Fang,

Yang

et al. 2024

Healthcare

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Objectives: The aim was to develop and validate the Communities Geriatric Mild Cognitive Impairment Risk Calculator (CGMCI-Risk), aiding community healthcare workers in the early identification of individuals at high risk of mild cognitive impairment (MCI). Methods: Based on nationally representative community survey data, backward stepwise regression was employed to screen the variables, and logistic regression was utilized to construct the CGMCI-Risk. Internal validation was conducted using bootstrap resampling, while external validation was performed using temporal validation. The area under the receiver operating characteristic curve (AUROC), calibration curve, and decision curve analysis (DCA) were employed to evaluate the CGMCI-Risk in terms of discrimination, calibration, and net benefit, respectively. Results: The CGMCI-Risk model included variables such as age, educational level, sex, exercise, garden work, TV watching or radio listening, Instrumental Activity of Daily Living (IADL), hearing, and masticatory function. The AUROC was 0.781 (95% CI = 0.766 to 0.796). The calibration curve showed strong agreement, and the DCA suggested substantial clinical utility. In external validation, the CGMCI-Risk model maintained a similar performance with an AUROC of 0.782 (95% CI = 0.763 to 0.801). Conclusions: CGMCI-Risk is an effective tool for assessing cognitive function risk within the community. It uses readily predictor variables, allowing community healthcare workers to identify the risk of MCI in older adults over a three-year span.

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Positive associations between sex hormones, bone metabolism and cognitive impairment in Chinese oldest-old females

Cited by 3 publications

References 44 publications

Association between serum 25-hydroxyvitamin D3 level and cognitive impairment in older chronic kidney disease patients

Association between serum 25-hydroxyvitamin D3 level and cognitive impairment in older chronic kidney disease patients

Impact of lifestyle and psychological resilience on survival among the oldest-old in China: a cohort study

Development and Validation of the Communities Geriatric Mild Cognitive Impairment Risk Calculator (CGMCI-Risk)

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