2011
DOI: 10.1101/gad.600211
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Positive control of cell division: FtsZ is recruited by SsgB during sporulation ofStreptomyces

Abstract: In bacteria that divide by binary fission, cell division starts with the polymerization of the tubulin homolog FtsZ at mid-cell to form a cell division scaffold (the Z ring), followed by recruitment of the other divisome components. The current view of bacterial cell division control starts from the principle of negative checkpoints that prevent incorrect Z-ring positioning. Here we provide evidence of positive control of cell division during sporulation of Streptomyces, via the direct recruitment of FtsZ by t… Show more

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Cited by 171 publications
(213 citation statements)
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“…SsgA activates sporulation-specific cell division (312,313), and both ssgA and ssgB are required for sporulation (275,314,315). The symmetrical spacing of the many Z-rings is achieved by SsgB, which directly recruits FtsZ and also stimulates its polymerization (316). SsgB localizes to future division sites prior to and independent of FtsZ (316).…”
Section: From Aerial Hyphae To Spores: Sporulation-specific Cell Divimentioning
confidence: 99%
“…SsgA activates sporulation-specific cell division (312,313), and both ssgA and ssgB are required for sporulation (275,314,315). The symmetrical spacing of the many Z-rings is achieved by SsgB, which directly recruits FtsZ and also stimulates its polymerization (316). SsgB localizes to future division sites prior to and independent of FtsZ (316).…”
Section: From Aerial Hyphae To Spores: Sporulation-specific Cell Divimentioning
confidence: 99%
“…Moreover, S. coelicolor has no obvi- ous MinC or MinE homologs. Recently, FtsZ positioning in S. coelicolor was shown to be under positive control by an FtsZ partner protein, SsgB, which, in turn, depends on SsgA (39). Interestingly, SsgA localizes at the hyphal tips in a dynamic fashion (40); therefore, it could, in principle, be part of the TIPOC (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Live-cell imaging of Streptomyces development has been challenging because of the complexity of the life cycle and the physiological characteristics of the organism. Previous studies on vegetative growth and the initial stages of sporulation septation have employed oxygen-permeable imaging chambers, or the agarose-supported growth of Streptomyces coelicolor on a microscope stage [11][12][13][14][15] . These methods, however, are limited by a number of factors.…”
Section: Introductionmentioning
confidence: 99%