Positive culture rate and antimicrobial susceptibilities of Mycoplasma hominis and Ureaplasma urealyticum

Abstract

ObjectiveTo assess positive culture rate and antimicrobial susceptibilities of Mycoplasma hominis (MH) and Ureaplasma urealyticum (UU) in symptomatic general population and pregnant women admitted with preterm labor and premature rupture of membranes.MethodsWe retrospectively reviewed medical records of patients who have undergone culture test and antimicrobial susceptibilities at our center from January 2017 to April 2018. Patients with positive culture for MH, UU, or both were included in this study.ResultsThere were 200 patients who were eligible for enrollment. Of these patients, 34 (17%) were pregnant women and 166 (83%) were non-pregnant women. Of these 200 patients, positive culture results were as follows: MH only, n=10 (5%); UU only, n=58 (29%); and both MH and UU, n=36 (18%). Susceptibilities of MH only to doxycycline, erythromycin, ciprofloxacin, and azithromycin were 100%, 10%, 40%, and 0%, respectively. Susceptibilities of UU only to doxycycline, erythromycin, ciprofloxacin, and azithromycin were 94.8%, 87.9%, 5.2%, and 81%, respectively. Susceptibilities of both MH and UU to doxycycline, erythromycin, ciprofloxacin, and azithromycin were 97.2%, 5.6%, 11.1%, and 11.1%, respectively.ConclusionUU only was the leading causative pathogen for genitourinary infection in our study. MH only accounted for about one sixth of UU only infections. Doxycycline was still the best antibiotics as most patients with MH only, UU only, or both MH and UU positive culture showed susceptibility. For ciprofloxacin, less than 12% of those with UU only and both MH and UU culture positive results showed susceptibility.

Prevalence and Antimicrobial Susceptibility of Mycoplasma hominis and Ureaplasma Species in Nonpregnant Female Patients in South Korea Indicate an Increasing Trend of Pristinamycin-Resistant Isolates

“…According to several studies conducted in South Korea, the prevalence of Ureaplasma species in symptomatic patients was higher than that of M. hominis . The prevalence of Ureaplasma species and M. hominis was 21.3% and 2.9%, as reported by Moon et al ( 8 ), 65.6% and 11.8% by Kweon et al ( 9 ), and 48.8% and 25.3% by Jang et al ( 10 ), respectively. Similar values were reported in Poland ( 11 ) and China ( 12 ).…”

Examination of Ureaplasma urealyticum and Mycoplasma hominis in 4082 Chinese patients

“…MH infection and UU+MH mixed infection were resistant to clarithromycin, roxithromycin, azithromycin, ofloxacin, and levofloxacin. This is because MH has multiple drug resistance genes, natural resistance to most macrocyclic ester drugs, and cross-resistance to quinolones (13). In this study, the sensitivities of doxycycline, minocycline, and josamycin were over 95%, while the resistance of ofloxacin, levofloxacin, and azithromycin were over 20%, which indicated that appropriate antibiotics should be selected for different types of Mycoplasma.…”

Особливості Біоценозу Піхви У Жінок Із Мікоплазмовою Інфекцією

“…Змішані інфекції становлять значну частину всіх випадків інфекційних захворювань генітального тракту, причому відзначається поєднання 3-х і більше збудників. Літературні дані свідчать про збільшення частоти виявлення мікробних асоціацій в ослаблених пацієнтів із хронічними захворюваннями статевих органів [8,9].…”