Positive Effects of Extra-Virgin Olive Oil Supplementation and DietBra on Inflammation and Glycemic Profiles in Adults With Type 2 Diabetes and Class II/III Obesity: A Randomized Clinical Trial

Silveira, Érika Aparecida; Rosa, Lorena Pereira de Souza; Resende, Danilo Pires; Rodrigues, Ana Paula; Costa, Adeliane Castro da; Rezende, Andréa Toledo de Oliveira; Oliveira, César de; Junqueira-Kipnis, Ana Paula

doi:10.3389/fendo.2022.841971

Cited by 4 publications

(3 citation statements)

References 60 publications

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“…The combined action of MUFA and polyphenol components on different metabolic pathways may contribute positively to control lipid metabolism, favor good glycemic control, and ensure good anti-inflammatory activity. Table 1 summarizes the main studies on the direct effect of OO intake on metabolic studies [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

“…The EVOO+DieTBra groups also showed decreased BMI, weight, serum levels of inflammatory cytokines, interleukin-1α (IL-1α), and adiponectin, as well as increased tumor necrosis factor α (TNF-α). This study concluded that EVOO+DieTBra has a role in ameliorating the inflammatory profiles and fasting insulin levels of adults having class II/III obesity and T2D [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

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Is There More to Olive Oil than Healthy Lipids?

Isaakidis,

Maghariki,

Carvalho-Barros

et al. 2023

Nutrients

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The Mediterranean diet is a healthy dietary pattern whose main characteristic is olive oil consumption. The potential health benefits of olive oil have been extensively investigated and the present review provides the more recent clinical evidence supporting the positive impact of olive oil intake on human health. PubMed (n = 227) and Scopus (n = 308) databases were searched for published clinical studies in English over the past six years (October 2016 to December 2022), following key word searches of “olive oil” and “health”. Major findings associated olive oil with antioxidant and anti-inflammatory effects, improvement in endothelial function and lipid profile, prevention of obesity, diabetes, cardiovascular and neurodegenerative diseases, and modulation of the gut microbiota. These benefits are attributed to the nutritional composition of olive oil, which has a high content of monounsaturated fatty acids (MUFA) (oleic acid in particular) and minor compounds such as polyphenols (oleuropein and hydroxytyrosol). Although additional research continues to be required, the more recently generated evidence supports the potential of olive oil to contribute beneficially to health and to the prevention and management of a variety of non-communicable diseases, as a consequence of the synergism between its components’ complexity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Is There More to Olive Oil than Healthy Lipids?

Isaakidis,

Maghariki,

Carvalho-Barros

et al. 2023

Nutrients

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show abstract

“…In a recent survey with the Brazilian diet, positive results were also found 26 , a study was carried out that evaluated the effects of extra virgin olive oil alone and in combination with a traditional Brazilian diet on inflammatory markers and glycemic profiles in adults with DM2 and class II obesity/ III. The intervention with Olive Oil + Brazilian Diet effectively decreased the levels of fasting insulin, IL-1α and adiponectin, suggesting its beneficial role in improving inflammatory profiles and fasting insulin levels in adults with class II/III obesity and T2DM.…”

Section: Source: Authors 2022mentioning

confidence: 99%

Effect of Consumption of Extravirgin Olive Oil on the Lipid Profile and on the Glycemia of Children with Cystic Fibrosis Seen at a Specialized Center in Belém-PA/ Brazil

Barbosa¹,

Pereira²,

Santos³

et al. 2022

IJAERS

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Introduction: Cystic fibrosis (CF) is a genetic disease that affects the cystic fibrosis transmembrane conductance regulatory protein (CFTR), which functions as a chlorine channel regulating the balance between ions and water across the epithelium. Nutrition has shown an important role in this problem due to the need for a differentiated dietary prescription through a hypercaloric and hyperlipidic diet associated with anthropometric monitoring, and as a food strategy extra virgin olive oil can bring several benefits due to its rich composition in acids. monounsaturated fatty acids (MUFA) and their bioactive compounds considered nutraceuticals, capable of modulating gene expression, interfering with the production of proteins and metabolites; It has anti-inflammatory, antioxidant and antimicrobial effects. Method: A clinical trial was carried out with children aged 2 to 11 years attended at the João de Barros Barreto University Hospital, at this age there were 20 children, 2 could not be contacted and 3 refused to participate, so the research had 15 individuals, the exposure group (n=8) received dietary monitoring and extra virgin olive oil for three months and the control group (n=7) the standard nutritional guidance for the disease. The variables were: lipid profile (total cholesterol, HDL, LDL and triglycerides), glycemic status (fasting glucose). Results: There was a reduction in the rates of fasting glucose (p=0.0355) and triglycerides (p=0.0157) with a significant difference when comparing the control and intervention groups. Discussion: no other study was found using the ingestion of pure extra virgin olive oil in people with cystic fibrosis, only studies with a mixture of olive oil and soy or docosahexaenoic acid, however, regarding the healthy population and other diseases, the tests that were significant fasting glucose and triglycerides were found several studies that demonstrate the benefit of olive oil in reducing these rates. Conclusion: Supplementation with extra virgin olive oil proved to be effective, however several factors can influence the health of these people such as lifestyle habits, general health status and individual genetic variants, so studies with longer intake time and with a greater number of participants, preferably multicenter, should be evaluated, but extra virgin olive oil is shown as another tool to aggregate the various measures to improve the quality of life of this population.

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Polyphenol hydroxytyrosol present olive oil improves skin wound healing of diabetic mice

Duarte,

Fuhro,

de Souza Nogueira

et al. 2024

Wound Repair Regeneration

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The imbalance in oxidant production and chronic inflammation are the main mechanisms that lead to the detrimental effects of diabetes on skin wound healing. Thus, administration of antioxidants could improve diabetic wound healing. This study aimed to understand the effects of extra virgin olive oil (EVOO) or hydroxytyrosol (HT) in skin wound healing under diabetic conditions. Skin wounds in streptozotocin‐induced diabetic mice were topically treated with HT. Some diabetic animals were fed with a diet rich in EVOO. Wounds were harvested 7 days later. In in vitro assays, fibroblasts and macrophages were treated with high levels of glucose and HT. The EVOO or HT promoted wound closure and collagen deposition in diabetic mouse wounds. The EVOO or HT reduced the number of infiltrated neutrophils, tumour necrosis factor‐α, lipid peroxidation, and nuclear factor erythroid 2‐related factor 2 in diabetic mouse wounds. The EVOO or HT also increased the number of macrophages with anti‐inflammatory phenotype and interleukin‐10 in diabetic mouse wounds. In the in vitro assays, HT promoted the fibroblast migration, collagen gel contraction, and switched macrophages to an anti‐inflammatory phenotype under high glucose conditions. In conclusion, the diet supplementation with EVOO or topical application of HT promotes skin wound healing under diabetic conditions and can be a possible therapeutic tool for the treatment of those lesions.

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Positive Effects of Extra-Virgin Olive Oil Supplementation and DietBra on Inflammation and Glycemic Profiles in Adults With Type 2 Diabetes and Class II/III Obesity: A Randomized Clinical Trial

Cited by 4 publications

References 60 publications

Is There More to Olive Oil than Healthy Lipids?

Is There More to Olive Oil than Healthy Lipids?

Effect of Consumption of Extravirgin Olive Oil on the Lipid Profile and on the Glycemia of Children with Cystic Fibrosis Seen at a Specialized Center in Belém-PA/ Brazil

Polyphenol hydroxytyrosol present olive oil improves skin wound healing of diabetic mice

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