Positive effects of Quercetin, Iron Oxide Nanoparticles and Ascorbic Acid composition in the treatment of women with metabolic syndrome

Abstract

Relevance of study. Metabolic syndrome (MS) increases the risk of atherosclerotic cardiovascular disease and type ІІ diabetes. Correction of the MS manifestations is important for reducing cardiovascular risk. Aim - to study the effects of using a composition consisting of quercetin (Q), polyvalent iron oxide nanoparticles (IONs) and ascorbic acid (AA) in women with MS. Materials and methods. 60 women with MS took part in the study. They were divided equally into two groups. The control group patients received a placebo for one month, and the main group received a composition of Q, IONs and AA for one month too. Anthropometric parameters, fasting plasma glucose level and standard oral glucose tolerance test (OGTT), serum lipid concentration, and microvascular endothelial function in a sample with reactive post-occlusion hyperemia were determined. Results. The use of the composition led to a decrease in the glycemia level of both on an empty stomach and after 2 hours of SGTT, the concentration of total cholesterol and low-density lipoproteins in blood serum in atherogenic dyslipidemia patients. At the same time, there was an improvement in the endothelium functional state of the microvessels, as evidenced by an increase in the maximum volume velocity of skin blood flow in the reactive hyperemia test. Conclusion. It was found that the use of a composition Q, IONs and AA had a positive effect on cardiovascular risk factors in MS patients. _________________________________________________________________________________________ Keywords: iron oxide nanoparticles; quercetin; metabolic syndrome; glucose and blood lipids; the microvascular endothelium function.