Positive expression of <i>PAX7</i> indicates poor prognosis of pediatric and adolescent AML patients

Yan, Tianyou; Naren, Duolan; Gong, Yuping

doi:10.1080/17474086.2020.1719826

Cited by 1 publication

(2 citation statements)

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“…The function of PAX7 is context and tumor-specific. It has been reported that the high expression of PAX7 indicates shorter OS and event-free survival in pediatric and adolescent acute myeloid leukemia (AML) patients (29). PAX7 has also been shown to be an independent prognostic factor for AML patients (29).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that the high expression of PAX7 indicates shorter OS and event-free survival in pediatric and adolescent acute myeloid leukemia (AML) patients (29). PAX7 has also been shown to be an independent prognostic factor for AML patients (29). However, PAX7 was overexpressed in Ewing Sarcoma (ES) biopsies and cell lines and associated with the good prognosis of ES patients (30).…”

Section: Discussionmentioning

confidence: 99%

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Identification and validation of a novel prognostic signature based on transcription factors in breast cancer by bioinformatics analysis

Yang¹,

Li²,

Zhao³

et al. 2022

Gland Surg

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Background: Breast cancer (BRCA) is the leading cause of cancer mortality among women, and it is associated with many tumor suppressors and oncogenes. There is increasing evidence that transcription factors (TFs) play vital roles in human malignancies, but TFs-based biomarkers for BRCA prognosis were still rare and necessary. This study sought to develop and validate a prognostic model based on TFs for BRCA patients.Methods: Differentially expressed TFs were screened from 1,109 BRCA and 113 non-tumor samples downloaded from The Cancer Genome Atlas (TCGA). Univariate Cox regression analysis was used to identify TFs associated with overall survival (OS) of BRCA, and multivariate Cox regression analysis was performed to establish the optimal risk model. The predictive value of the TF model was established using TCGA database and validated using a Gene Expression Omnibus (GEO) data set (GSE20685). A gene set enrichment analysis was conducted to identify the enriched signaling pathways in high-risk and low-risk BRCA patients. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of the TF target genes were also conducted separately.

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Section: Discussionmentioning

confidence: 99%